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Table 4 Risks of psychiatric disorders, suicide attempt and suicide in siblings of individuals with hypermobility syndrome (hypermobility syndrome siblings) compared with matched siblings to individuals without hypermobility syndrome (comparison siblings)

From: Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers–Danlos syndrome or hypermobility syndrome and their siblings

 

Hypermobility syndrome siblings (n = 11,082)

Comparison siblings (n = 108,772)

  
 

n (%)

n (%)

RR (95 % CI)

RRa (95 % CI)

Autism spectrum disorder

66 (0.6)

500 (0.5)

1.3 (1.1–1.7)

1.3 (1.1–1.7)

Bipolar disorder

31 (0.3)

269 (0.3)

1.1 (0.8–1.6)

1.2 (0.8–1.7)

ADHD

124 (1.1)

966 (0.9)

1.3 (1.1–1.5)

1.3 (1.1–1.5)

Depression

343 (3.1)

2,788 (2.6)

1.2 (1.1–1.3)

1.2 (1.1–1.3)

Suicide attempt

270 (2.4)

2,182 (2.0)

1.2 (1.1–1.4)

1.2 (1.1–1.4)

Suicide

29 (0.3)

230 (0.2)

1.2 (0.9–1.7)

1.3 (0.9–1.8)

Schizophrenia

26 (0.2)

184 (0.2)

1.4 (0.9–2.0)

1.3 (0.9–1.9)

  1. Associations are expressed as risk ratios (RR) and 95 % confidence intervals (95 % CIs) from conditional logistic regression
  2. Note: statistically significant RR are bolded. RRa, risk ratios restricted to individuals born in Sweden