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Table 3 The association of BMI with any subsequent psychotropic medication as well as antidepressant and sedative medication: Cox regression analysis (hazard ratios, HR, and their 95 % confidence intervals (95 % CI)

From: Obesity and psychotropic medication: a prospective register linkage study among midlife women and men

  

Model 1

Model 2

Model 3

Model 4

 

BMI (kg/m2)a

HR

95 % CI

HR

95 % CI

HR

95 % CI

HR

95 % CI

Any psychotropic medication

 Women

Normal weight

1.00

-

1.00

-

1.00

-

1.00

-

 

Overweight

1.06

0.95–1.19

1.00

0.89–1.12

0.97

0.87–1.09

0.94

0.84–1.06

 

Obese

1.05

0.89–1.24

0.93

0.78–1.10

0.90

0.76–1.06

0.84

0.71–1.00

 

Severely obese

1.23

0.94–1.61

1.23

0.94–1.61

1.16

0.89–1.53

1.03

0.79–1.36

 Men

Normal weight

1.00

-

1.00

-

1.00

-

1.00

-

 

Overweight

1.18

0.91–1.51

1.14

0.88–1.47

1.12

0.87–1.44

1.09

0.84–1.41

 

Obese

1.57

1.10–2.24

1.37

0.96–1.97

1.26

0.87–1.82

1.15

0.79–1.66

 

Severely obese

2.15

1.29–3.56

1.76

1.06–2.92

1.51

0.90–2.53

1.19

0.70–2.03

Antidepressants

 Women

Normal weight

1.00

-

1.00

-

1.00

 

1.00

-

 

Overweight

1.10

0.96–1.26

1.05

0.91–1.20

1.00

0.86–1.15

0.96

0.83–1.11

 

Obese

1.20

0.99–1.46

1.08

0.89–1.32

1.02

0.83–1.25

0.94

0.77–1.16

 

Severely obese

1.32

0.95–1.82

1.29

0.93–1.77

1.15

0.83–1.60

1.01

0.72–1.40

 Men

Normal weight

1.00

-

1.00

-

1.00

-

1.00

-

 

Overweight

1.17

0.87–1.58

1.12

0.83–1.52

1.10

0.81–1.49

1.09

0.80–1.48

 

Obese

1.44

0.93–2.22

1.20

0.77–1.86

1.05

0.67–1.65

0.95

0.60–1.50

 

Severely obese

1.78

0.94–3.37

1.36

0.72–2.59

1.10

0.57–2.11

0.93

0.48–1.80

Sedatives

 Women

Normal weight

1.00

-

1.00

-

1.00

-

1.00

-

 

Overweight

1.01

0.88–1.17

0.95

0.82–1.09

0.92

0.80–1.07

0.92

0.79–1.06

 

Obese

0.91

0.73–1.13

0.79

0.64–0.99

0.78

0.62–0.98

0.76

0.61–0.95

 

Severely obese

1.07

0.75–1.53

1.06

0.74–1.50

1.04

0.73–1.49

0.99

0.69–1.43

 Men

Normal weight

1.00

-

1.00

-

1.00

-

1.00

-

 

Overweight

1.26

0.91–1.73

1.26

0.91–1.73

1.27

0.92–1.75

1.21

0.87–1.68

 

Obese

1.69

1.09–2.63

1.50

0.96–2.34

1.44

0.91–2.27

1.38

0.88–2.19

 

Severely obese

3.09

1.77–5.39

2.61

1.49–4.55

2.44

1.38–4.31

2.12

1.17–3.84

  1. a Body mass index (BMI) was categorised into four groups: normal weight 18.5–24.9 kg/m2, overweight 25–29.9 kg/m2, obese 30–34.9 kg/m2 and severely obese ≥35 kg/m2
  2. Model 1: Adjusted for age
  3. Model 2: Adjusted for age and previous psychotropic medication
  4. Model 3: Adjusted for covariates in model 2, socio-demographic factors, health behaviours and strenuousness of work
  5. Model 4: Adjusted for covariates in model 3, physical functioning and somatic health