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Table 3 The association of BMI with any subsequent psychotropic medication as well as antidepressant and sedative medication: Cox regression analysis (hazard ratios, HR, and their 95 % confidence intervals (95 % CI)

From: Obesity and psychotropic medication: a prospective register linkage study among midlife women and men

   Model 1 Model 2 Model 3 Model 4
  BMI (kg/m2)a HR 95 % CI HR 95 % CI HR 95 % CI HR 95 % CI
Any psychotropic medication
 Women Normal weight 1.00 - 1.00 - 1.00 - 1.00 -
  Overweight 1.06 0.95–1.19 1.00 0.89–1.12 0.97 0.87–1.09 0.94 0.84–1.06
  Obese 1.05 0.89–1.24 0.93 0.78–1.10 0.90 0.76–1.06 0.84 0.71–1.00
  Severely obese 1.23 0.94–1.61 1.23 0.94–1.61 1.16 0.89–1.53 1.03 0.79–1.36
 Men Normal weight 1.00 - 1.00 - 1.00 - 1.00 -
  Overweight 1.18 0.91–1.51 1.14 0.88–1.47 1.12 0.87–1.44 1.09 0.84–1.41
  Obese 1.57 1.10–2.24 1.37 0.96–1.97 1.26 0.87–1.82 1.15 0.79–1.66
  Severely obese 2.15 1.29–3.56 1.76 1.06–2.92 1.51 0.90–2.53 1.19 0.70–2.03
Antidepressants
 Women Normal weight 1.00 - 1.00 - 1.00   1.00 -
  Overweight 1.10 0.96–1.26 1.05 0.91–1.20 1.00 0.86–1.15 0.96 0.83–1.11
  Obese 1.20 0.99–1.46 1.08 0.89–1.32 1.02 0.83–1.25 0.94 0.77–1.16
  Severely obese 1.32 0.95–1.82 1.29 0.93–1.77 1.15 0.83–1.60 1.01 0.72–1.40
 Men Normal weight 1.00 - 1.00 - 1.00 - 1.00 -
  Overweight 1.17 0.87–1.58 1.12 0.83–1.52 1.10 0.81–1.49 1.09 0.80–1.48
  Obese 1.44 0.93–2.22 1.20 0.77–1.86 1.05 0.67–1.65 0.95 0.60–1.50
  Severely obese 1.78 0.94–3.37 1.36 0.72–2.59 1.10 0.57–2.11 0.93 0.48–1.80
Sedatives
 Women Normal weight 1.00 - 1.00 - 1.00 - 1.00 -
  Overweight 1.01 0.88–1.17 0.95 0.82–1.09 0.92 0.80–1.07 0.92 0.79–1.06
  Obese 0.91 0.73–1.13 0.79 0.64–0.99 0.78 0.62–0.98 0.76 0.61–0.95
  Severely obese 1.07 0.75–1.53 1.06 0.74–1.50 1.04 0.73–1.49 0.99 0.69–1.43
 Men Normal weight 1.00 - 1.00 - 1.00 - 1.00 -
  Overweight 1.26 0.91–1.73 1.26 0.91–1.73 1.27 0.92–1.75 1.21 0.87–1.68
  Obese 1.69 1.09–2.63 1.50 0.96–2.34 1.44 0.91–2.27 1.38 0.88–2.19
  Severely obese 3.09 1.77–5.39 2.61 1.49–4.55 2.44 1.38–4.31 2.12 1.17–3.84
  1. a Body mass index (BMI) was categorised into four groups: normal weight 18.5–24.9 kg/m2, overweight 25–29.9 kg/m2, obese 30–34.9 kg/m2 and severely obese ≥35 kg/m2
  2. Model 1: Adjusted for age
  3. Model 2: Adjusted for age and previous psychotropic medication
  4. Model 3: Adjusted for covariates in model 2, socio-demographic factors, health behaviours and strenuousness of work
  5. Model 4: Adjusted for covariates in model 3, physical functioning and somatic health