Fig. 2

The potential neurobiological targets associated with mental illness trajectory organised by functional domain. This is a model illustrating the potential neurobiological targets for each functional domain identified by this systematic review. At the centre is ‘mental illness trajectory’ that is a term employed here to encompass all the characteristic features of illness, and its associated short term and long term outcomes. Surrounding this are the five functional domains investigated by this review to illustrate how a young person’s mental illness trajectory is made up of and influenced by each of these functional domains. Within the respective sections of the figure, the potential neurobiological targets for each functional domain identified by this systematic review are highlighted in the boxes. The absence of any neurobiological targets in the physical health section of the figure reflects the lack of investigation into this particular functional domain emphasising the need for more research into this area. The clinical syndrome section is the most populated which reflects the predominant focus in the literature on this particular domain. Despite less focus on the remaining three functional domains, the evidence for potential neurobiological targets for these areas is promising for clinical utility and future research