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Table 3 Clinical characteristics of the first cohort (N = 134)

From: Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort

Characteristic

Patients with MDD (N = 85)

Healthy participants (N = 49)

Female:Male, N (%)

50:35 (59 %:41 %)

32:17 (65 %:35 %)

Age in years, mean (SD), range

36.1 (12.5), 19–61

32.5 (10.2), 20–57

Ethnicitya, N (%)

  

Aboriginal

0

0

Arab

3 (4 %)

1 (2 %)

Asian

9 (11 %)

9 (18 %)

Black

1 (1 %)

0

Latin American/Hispanic

5 (6 %)

2 (4 %)

White

59 (69 %)

35 (71 %)

Other

5 (6 %)

2 (4 %)

Mixed

3 (4 %)

0

Marital status, N (%)

  

Never Married

48 (57 %)

26 (53 %)

Separated

7 (8 %)

1 (2 %)

Married

16 (19 %)

12 (25 %)

Divorced

7 (8 %)

3 (6 %)

Domestic Partnership

5 (6 %)

6 (12 %)

Widowed

2 (2 %)

1 (2 %)

Occupational status, N (%)

  

Working now

45 (53 %)

28 (57 %)

Disabled (permanent or temporary)

13 (7 %)

0

Temporary leave

5 (3 %)

0

Looking, unemployed

10 (5 %)

3 (6 %)

Student

8 (4 %)

15 (31 %)

Retired

1 (1 %)

0

If employed, number of hours scheduled to work over the past 2 weeks: mean (SD)

50.0 (27.2)

53.8 (25.8)

If employed, number of hours missed due to symptoms over the past 2 weeks: mean (SD)

10.5 (18.2)

0.1 (0.6)

Education, years: mean (SD)

14.1 (2.0)

15.9 (2.9)

Age of onset of MDD, years:

  

mean (SD), range

20.6 (10.7), 5–55

n/a

Single episode:Recurrent, N (%)

24:61 (29 %:71 %)

n/a

No. previous episodes, mean (SD)

4.3 (2.8)

n/a

Current episode duration

  

≤12 months

39 (46 %)

n/a

1–2 years

13 (15 %)

 

>2 years

30 (35 %)

 

Unknown/not reported

3 (4 %)

 

Median duration (range), months

14.5 (3–151)

 

Comorbiditiesb,c

  

Substance-Related Disorders

7 (8 %)

n/a

Anxiety Disorders

67 (79 %)

 

Eating Disorders

1 (1 %)

 

Stable medical conditions

52 (61 %)

 

Use of antidepressants during current

  

episode, N (%)

60 (71 %)

n/a

No. antidepressants used, mean (SD)

1.7 (1.5)

 

Baseline MADRS, mean (SD)

29.9 (6.0)

0.4 (1.0)

Baseline YMRS, mean (SD)

2.2 (1.8)

0.3 (0.7)

Baseline CGI Severity, mean (SD)

4.7 (0.8)

1.0 (0.0)

Baseline QIDS-SR, mean (SD)

15.9 (4.3)

2.1 (1.7)

Baseline SDS, mean (SD)

16.6 (7.5)

0.0 (0.0)

Baseline LEAPS, mean (SD)

14.1 (6.1)

1.9 (2.7)

  1. aCategories adapted from ethnic-origin groups listed in national census questionnaires [67]
  2. bBased on DSM-IV-TR, as determined by the Mini International Neuropsychiatric Interview
  3. cPercentages may not add up to 100 % because patients may have more than 1 comorbid condition
  4. MDD Major depressive disorder, SD Standard deviation, MADRS Montgomery Åsberg Depression Rating Scale, YMRS Young Mania Rating Scale, CGI Clinical Global Impression, QIDS-SR Quick Inventory of Depressive Symptomatology, Self-Report, SDS Sheehan Disability Scale, LEAPS Lam Employment Absence and Productivity Scale
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BMC Psychiatry

ISSN: 1471-244X

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