Developing a clinical translational neuroscience taxonomy for anxiety and mood disorder: protocol for the baseline-follow up Research domain criteria Anxiety and Depression (“RAD”) project

Table 2 A summary of the measures used in the trial to assess circuit function, behavior and self-report and observer rated symptoms and real-world function

fMRI Paradigms	Behavioral Tasks	Self and Observer Report
Negative Affect Circuit		Clinical Measures	Real World Function
Masked Facial Expressions of Threat	Threat Identification and Bias	Symptoms of anxiety and negative mood:	Coping:
Threat Conflict Regulation	Threat Conflict Adaptation	BAI, PSWQ, BDI, QIDS-SR, DASS, MASQ	COPE
			Emotion Regulation:
			ERQ
Cognitive Control Circuit		Symptoms of associated traumatic stress, impulsivity, and substance use:	Social and Occupational Function:
Go-NoGo	Go-NoGo	PCL-C, BIS, FTND, DSM 5 AUD, DSM 5 SUD, AUDIT, CUDIT, NM-ASSIST	SOFAS
			Quality of Life:
			WHOQoL, SWLS
N-Back Continuous Performance	Digit Span	Trauma-related risk:	Work productivity:
	Verbal Learning and Memory	ELSQ	HPQ

Abbreviations: BAI Beck Anxiety Inventory, PSWQ Penn State Worry Questionnaire, BDI Beck Depression Inventory, QIDS-SR Quick Inventory of Depressive Symptomatology-Self Report, DASS depression anxiety stress scales, MASQ Mood and Anxiety Symptom Questionnaire, PCL-C Posttraumatic Stress Disorder CheckList-Civilian Version, BIS Barratt Impulsivity Scale, FTND Fagerstrom Test for Nicotine Dependence, DSM 5 AUD DSM 5 Alcohol Use Disorder, AUDIT alcohol use disorders identification test, DSM 5 SUD DSM 5 substance use disorder, NM-ASSIST NIDA-Modified Alcohol, Smoking and Substance Involvement Screening Test, CUDIT Cannabis Use Disorder Identification Test, ELSQ Early Life Stress Questionnaire, COPE Brief COPE, ERQ Emotion Regulation Questionnaire, SOFAS Social and Occupational Functional Assessment Scale, WHOQOL World Health Organization Quality of Life Scale, SWLS satisfaction with life scale, HPQ World Health Organization Health and Work Performance Questionnaire

ISSN: 1471-244X