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Table 1 Patient characteristics and stimulation settings

From: Removing and reimplanting deep brain stimulation therapy devices in resistant OCD (when the patient does not respond): case report

Sex

Male

Age at OCD Onset

11

Age at surgery

19

Worst YBOCS ever

38

Worst HDRS ever

12

Pharmacological resistance profile1

Fluoxetine 60 mg/d

Fluvoxamine 300 mg/d

Sertraline 200 mg/d

Escitalopram 20 mg/d

Clomipramine 300 mg/d

Venlafaxxine 150 mg/d

Phenelzine 60 mg/d

Pimozide 2 mg/d

Risperidone 3 mg/d

Amisulpride 200 mg/d

Aripiprazole 15 mg/d

 

1st Surgery

2nd Surgery

Treatment2

CLM 262.5 mg/d + ESCIT 20 mg/d + RIS 1.5 mg/d + AGOM 25 mg/d

CLM 265.5 mg/d + ESCIT 40 mg/d + RIS 1.5 mg/d

Stimulation settings

0 + 1-, 210 μs, 135 Hz, 4 V

4 + 5-, 210 μs, 135 Hz, 4 V

0-1+, 270 μs, 60 Hz, 3 V

5-6+, 270 μs, 60 Hz, 3 V

Best YBOCS reached

35

26

Best HDRS reached

12

7

Best GAF reached

30

65

Position of the center of the stimulation*

Left (0–1)

Right (4–5)

Left (0–1)

Right (5–6)

x

5,29

10,54

9,02

8,57

y

5,47

3,54

−3,12

−4,46

z

−4,26

−0,85

2,87

−1,32

  1. 1Pharmacological resistance profile refers to all the different pharmacological trials conducted during the whole follow-up (since the patient was first treated at 11 years old until he performed the first surgery). Doses of these drugs were maintained for at least 12 weeks, to complete the trials
  2. 2Treatment refers to the precise combination of drugs that the patient was taking when the best Y-BOCS and HDRS scores were achieved
  3. *Distance from the anterior commissure (AC)
  4. Abbreviations: OCD obsessive-compulsive disorder, Y-BOCS Yale-Brown Obsessive Compulsive Scale, HDRS Hamilton Depression Rating Scale, GAF Global Assessment Functioning scale, CLM clomipramine, ESCIT escitalopram, RIS risperidone, AGOM agomelatine, x lateral, y anteroposterior, z axial