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Table 1 Demographic and clinical characteristics

From: Distinguishing bipolar and major depressive disorders by brain structural morphometry: a pilot study

 

BD (n = 16)

MDD (n = 19)

HC (n = 29)

F/χ2/t-scores

p-value

Male % (male/female)

37.5 % (6/10)

42.1 % (8/11)

37.9 % (11/18)

χ2 = 0.11

0.95

Right-handed %

100

100

100

F(2) = 0.00

1.00

Age (in years)

26.3 (7.9)

30.0 (8.9)

27.1 (8.4)

F(2) = 1.02

0.37

Education (in years)

15.1 (1.8)

14.4 (3.2)

14.9 (2.5)

F(2) = 0.42

0.66

IQ estimates

116.9 (16.1)

116.7 (13.1)

120.4 (12.7)

F(2) = 0.54

0.59

Intracranial Volume (ICV, cm3)

1295 (207)

1439 (195)

1372 (201)

F(2) = 2.24

0.12

Medication History

 Untreated (N)

5

8

/

/

/

 Antidepressants (N)

5

11

/

/

/

 Antipsychotics (N)

8

2

/

/

/

 CPZ (mg)

226.2 (327.4)

38.3 (40.1)

/

/

/

 Atypical (N)

8

1

/

/

/

 Typical (N)

0

1

/

/

/

 Trihexyphenidyl (N)

1

0

/

/

/

 Antianxiety (N)

2

3

/

/

/

 Lithium (N)

2

0

/

/

/

 Valproate (N)

2

0

/

/

/

 Lithium + Valproate (N)

1

0

/

/

/

Clinical Information

 Duration of illness (in years)*

5.2 (4.8)

4.9 (3.5)

/

t = -0.23

0.82

 HAMD-17*

9.9 (4.5)

11.1 (4.3)

/

t = 0.77

0.45

 YMRS*

6.40 (6.9)

2.2 (2.6)

/

t = -2.35

0.03

  1. Abbreviations: MDD Major Depressive Disorder, BD Bipolar Disorder, HC Health Controls, YMRS Young Mania Rating Scale, HAMD-17 Hamilton rating scale for Depression-17 items, N number of patients
  2. *p-values were generated from comparisons between the BD and MDD groups (t-tests, two-tailed)
  3. Chi-squared test was used in gender. One-way analyses of variance (ANOVA) were used in age, IQ estimates, handedness, education and ICV