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Fig. 4 | BMC Psychiatry

Fig. 4

From: Contribution of estradiol levels and hormonal contraceptives to sex differences within the fear network during fear conditioning and extinction

Fig. 4

Hippocampus and insular cortex activations as a function of hormonal status grouping in response to shock delivery. Significant functional activations of the hippocampus (a) and the insular cortex (b) during shock delivery of the fear-conditioning phase are displayed. The Montreal Neurological Institute (MNI) coordinates are listed below each functional activation, along with the corresponding statistics (note that the reported p values are FWE corrected). The lower panel indicates the BOLD signal extracted from the corresponding cluster as a function of the different groups during shock delivery for the hippocampus (a) and the insular cortex (b). FWE: family-wise error, M: men, HE: high estradiol women, LE: low estradiol women, OC: oral contraceptive users. Significant differences are noted (*p < 0.05 **p < 0.01)

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