Table 2 Inclusion/exclusion criteria and reasoning

Minimum age of 18 years

To ensure a minimum age for participation

Cocaine use > 3 occasions in the past 30 days

To also include occasional users to provide extended study validity

Exclusion Criteria

Reasoning

Participation in other psycho-social or pharmacological treatments for the reduction/cessation of cocaine use

To avoid confounding treatment effects

Opioid use during the past 30 days (exception: substitution maintenance treatment for opioid dependence without heroin use in the past 30 days)

To avoid confounding drug effects

Previous treatment for cardiovascular problems or apoplexy

To avoid that subjects who have these health problems