Inclusion criteria | |
---|---|
1. | Female |
2. | Age between 18 and 55Â years |
Additional inclusion criteria for CFS patients | |
1. | CFS diagnosis according to the CDC-criteria ([66]; Reeves et al., [2]); |
2. | Fatigue severity subscale (CIS) score ≥40 |
3. | Severely disabled, defined by scoring ≥ 700 on the Sickness Impact Profile (SIP) |
4. | Eligible for treatment with CBT |
Additional inclusion criteria for healthy controls | |
5. | Fatigue severity subscale (CIS) score ≤ 35 |
Exclusion criteria | |
1. | Current use of psychotropic medication (e.g. antidepressants) |
2. | Contra-indication for MR-examinations (e.g. claustrophobia) |
3. | Abnormal hearing or (uncorrected) vision |
4. | Insufficient command of the Dutch language to fill out questionnaires, understand task instructions or perform the neuropsychological tests |
5. | Restricted function of the right hand that confounds handgrip performance for the fMRI tasks |
Additional exclusion criteria for healthy controls | |
6. | Current psychological or psychiatric disordera,b |
7. | (History of) alcohol or substance abusea |
8. | Severe obesity (BMI ≥ 40)a |
9. | Chronic disease or pain condition (e.g. rheumatoid arthritis) |
10. | Current acute pain condition |