From: The Effects of Stress on Cognitive Aging, Physiology and Emotion (ESCAPE) Project
Construct | Domain | Description | Measures |
---|---|---|---|
Stress | Chronic | Role and environmental stress, neighborhood security, discrimination | Wheaton Chronic Stress (WCS) Scale, Lifetime Discrimination Scale, Neighborhood Safety and Violence Scale [70–72] |
Major events | Lifetime & recent exposure to major life events and trauma (e.g., bereavement, abuse) | Lifetime Adversity and Recent Life Event subscales of WCS [70] | |
Subjective | Perceived stressfulness of life over last month | Perceived Stress Scale [73] | |
Daily events | Exposure to daily hassles and stressors (e.g., arguments, deadlines, illness) | Adapted from Daily Inventory of Stressful Experiences [74] | |
URT | Event-related | Recurring thoughts about major stressor | Impact of Events Scale-Revised [75] |
Dispositional | Tendency to ruminate or reflect | Rumination-Reflection Questionnaire [38]; White Bear Suppression Inventory [37] | |
Momentary | Experiencing recurring, unwanted, negative thoughts | Momentary Thought Questionnaire | |
Cognition | Laboratory | Working memory | Operation-span, Counting-span, Backward letter span |
episodic memory | AVLT, Paired-associates, Card Memory Task | ||
processing speed | Letter, Number and Symbol matching | ||
fluid and crystallized intelligence | Ravens Progressive Matrices; Vocabulary | ||
 | Ambulatory | Working memory (verbal, spatial), processing speed | See Fig. 2 |
Biomarkers | Laboratory | Basal inflammatory markers | Plasma cytokines: IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, TNF-α, IFN-γ, GM-CSF; Plasma CRP |
Ambulatory | LPS-stimulated cytokines | Plasma cytokines: IL-1β, IL-6, IL-8, IL-10, TNF-α, GM-CSF | |
Stress-related hormones | Salivary cortisol sampled 4 times per day for the first 5 days of each burst | ||
Plasma cortisol; Plasma DHEAS | |||
Physical & Mental Health | Objective | Metabolic risk indicators | Lipid profiles; insulin; glucose |
 | Subjective | Physical functioning, medical history, medication use, anxiety, depression, mood over last month, life satisfaction | PROMIS Physical Function Short Form-A, PROMIS Emotional Distress – Anxiety – Short Form 7-A, PROMIS Depression Short From 8-A, Positive and Negative Affect Schedule, Satisfaction with Life Scale [64, 76, 77] |
Risk & Protective Factors | Risk | Neuroticism, social isolation, childhood adversity, anger | International Personality Item Pool (IPIP) Neuroticism subscale, PROMIS Social Isolation – Short Form-6a, Childhood Adversity subscale from WCS, State-Trait Anger Expression Inventory [70, 78, 79] |
 | Protective | Conscientiousness, social support, positive events, optimism, adult temperament, mindfulness | IPIP Conscientiousness subscale, PROMIS Emotional, Informational, and Instrumental Social Support – Short Forms-6a, Pleasant Events Schedule, Life Orientation Test, Adult Temperament Questionnaire, Five Facet Mindfulness Questionnaire [64, 78, 80–83] |
Demographics | Person | Age, race, ethnicity, gender | Demographic questionnaire |
 | Context | income, work status, marital status, education |  |