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Table 6 Sociodemographic and clinical comparison of ASD and disease-control samples by gender

From: Autism beyond diagnostic categories: characterization of autistic phenotypes in schizophrenia

 

ASD sample

 

Disease-control sample a

 
 

Men

Women

p-value

Men

Women

p-value

 

N = 70-107

N = 37-58

 

N = 58-71

N = 21-29

 

Sociodemographic variables

      

Age at examination, mean ± SD, yearsb

31.3 ± 11.3

34.1 ± 10.3

.050

37.6 ± 13.9

38 ± 11.2

.747

Years of education, mean ± SDb

14.6 ± 4.1

16.5 ± 4.8

.040

15.9 ± 4.4

16.2 ± 4.8

.529

Current occupation, No. (%), full-time workb

25 (23.4)

14 (24.1)

1.00

18 (25.4)

10 (34.5)

.462

Marital status, No. (%), singlec

67 (62.6)

34 (58.6)

.620

40 (56.3)

12 (41.4)

.193

Children, No (%), nonec

68 (86.1)

35 (81.4)

.602

42 (66.7)

12 (50)

.216

Relationship status, No. (%), no relationshipc

47 (43.9)

21 (36.2)

.408

35 (49.3)

10 (34.5)

.192

Clinical variables

      

Wechsler Adult Intelligence Scale-Revised, IQ

      

subtest comprehension

117 ± 20

115 ± 18

.396

113 ± 17

114 ± 12

.949

subtest similarities

114 ± 17

117 ± 13

.465

116 ± 18

117 ± 18

.705

subtest picture completion

105 ± 23

113 ± 17

.072

108 ± 20

107 ± 18

.728

subtest block design

108 ± 22

110 ± 17

.711

108 ± 18

108 ± 17

.643

estimated verbal IQ

115 ± 17

116 ± 13

.937

114 ± 16

115 ± 13

.825

estimated performance IQ

106 ± 20

111 ± 15

.143

107 ± 18

108 ± 15

.851

estimated total IQ

110 ± 17

113 ± 12

.302

111 ± 16

111 ± 12

.837

GAF, mean ± SDb

69.4 ± 17.1

74 ± 14.2

.191

75.1 ± 14.7

76.5 ± 15.8

.509

PANSS autism severity score, mean ± SDb

20.3 ± 7.7

20.1 ± 7.5

.842

13.3 ± 6.5

13.5 ± 6.7

.597

ADOS original algorithm Module 4, mean ± SDb

11.9 ± 4.1

12 ± 4.3

.962

3.9 ± 4

3.4 ± 3.8

.691

Autism Quotient (AQ), mean ± SDb,d

22.3 ± 5.9

25.6 ± 4.7

.006

22.8 ± 5.3

25 ± 4.2

.071

Empathy Quotient (EQ), mean ± SDb,e

18.6 ± 8

15.4 ± 7.6

.044

20.4 ± 10.2

16.7 ± 10.5

.108

  1. Multiple testing adjusted significances (Bonferroni: p ≤ 0.002) for comparison of each diagnostic group with ASD group are shown: due to missing data upon phenotyping, sample size varies between N = 186-265 in the total sample; a this category includes affective disorders, attention deficit disorder, pervasive developmental disorder not otherwise specified, anxiety disorders, alcohol use disorders; b Mann-Whitney U test; c Chi-square test; d Higher values correspond to more autistic traits; e Higher values correspond to more empathy (i.e. less autistic traits).