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Table 1 Characteristics of cases (patients with first record of pulmonary embolism) and matched controls at index date

From: Antipsychotic drug exposure and risk of pulmonary embolism: a population-based, nested case–control study

  Cases (n = 232) Controls (n = 4353) P value*
Mean age ± SD 77.1 ± 13.5 76.9 ± 13.7 0.798
  Age ≥ 65 194 (83.6%) 3,610 (82.9%)  
  Age < 65 38 (16.4%) 743 (17.1%)  
Women 157 (67.7%) 2,950 (67.8%) 0.975
Men 75 (32.3%) 1,403 (32.2%)  
Hospitalization§    
  Mental disorders 72 (31.0%) 468 (10.8%) <.001
  Coronary heart disease 22 (9.5%) 114 (2.6%) <.001
  Heart failure 21 (9.1%) 118 (2.7%) <.001
  Stroke 12 (5.2%) 108 (2.5%) 0.012
  Chronic liver disease 5 (2.2%) 19 (0.4%) 0.000
  Parkinson’s disease 32 (13.8%) 481 (11.0%) 0.197
  Chronic renal disease 20 (8.6%) 90 (2.1%) <.001
Drug use§    
  Lithium 5 (2.2%) 84 (1.9%) 0.808
  Statins 39 (16.8%) 744 (17.1%) 0.912
  NSAIDs 67 (28.9%) 1,036 (23.8%) 0.078
  Antiplatelet treatment 123 (53.0%) 1,981 (45.5%) 0.025
  Anti-diabetic 34 (14.7%) 613 (14.1%) 0.807
  Antihypertensive agents 155 (66.8%) 2,608 (59.9%) 0.036
  1. *chi-square statistics.
  2. § in the 12 months preceding index date.
  3. NSAIDs = non-steroidal anti-inflammatory drugs.