Table 1 Schedule of the study visits and planned assessments in OFFER trial

1

Clinical measures

PANSS

X

X

X

X

X

X

X

X

X

CGI-S

X

X

X

X

X

X

X

X

X

CGI-I

X

X

X

X

X

X

X

X

X

CDSS

X

X

X

X

X

X

X

X

X

GAF

X

X

X

X

X

X

X

X

X

2

Insight questionnaire

“My thoughts and feelings”

X

X

X

X

3

Prostaglandin synthesis (PGD2, PGE2)

Niacin flush skin test

X

X

X

4

Cognitive function tests: Working memory and Executive functions

TMT Part A and B, and their alternate forms, i.e. Part C, D and Digit Span Forward and Backward

X

X

X

Verbal memory

CVLT

X

X

X

Visual memory

BVRT

X

X

X

Abstract thinking

Halstead Category Test

X

X

X

Verbal fluency

Semantic and Phonological

X

X

X

5

Magnetic Resonance Imaging

Grey matter thickness - VBM

X

X

Fractional anisotropy – DTI

X

X

6

Oxidative stress

Isoprostane 8-epi-PGF2alpha (plasma)

X

X

X

Antioxidative defense

Total plasma antioxidative capacity

X

X

X

7

Neuronal plasticity

Plasma BDNF concentration

X

X

X

8

Dietary questionnaire

Diet history questionnaire

X

9

Metabolic syndrome traits

Plasma lipid profile

X

X

X

X

(biochemical assessments)

Fasting Blood Glucose level

X

X

X

X

10

Metabolic syndrome traits

Body weight

X

X

X

X

X

X

X

X

X

Waist circumference

X

X

X

X

X

X

X

X

X

(clinical measures)

Blood pressure

X

X

X

X

X

X

X

X

X