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A randomized controlled trial of mental health interventions for survivors of systematic violence in Kurdistan, Northern Iraq
BMC Psychiatry volume 14, Article number: 360 (2014)
Experiencing systematic violence and trauma increases the risk of poor mental health outcomes; few interventions for these types of exposures have been evaluated in low resource contexts. The objective of this randomized controlled trial was to assess the effectiveness of two psychotherapeutic interventions, Behavioral Activation Treatment for Depression (BATD) and Cognitive Processing Therapy (CPT), in reducing depression symptoms using a locally adapted and validated version of the Hopkins Symptom Checklist and dysfunction measured with a locally developed scale. Secondary outcomes included posttraumatic stress, anxiety, and traumatic grief symptoms.
Twenty community mental health workers, working in rural health clinics, were randomly assigned to training in one of the two interventions. The community mental health workers conducted baseline assessments, enrolled survivors of systematic violence based on severity of depression symptoms, and randomly assigned them to treatment or waitlist-control. Blinded community mental health workers conducted post-intervention assessments on average five months later.
Adult survivors of systematic violence were screened (N = 732) with 281 enrolled in the trial; 215 randomized to an intervention (114 to BATD; 101 to CPT) and 66 to waitlist-control (33 to BATD; 33 to CPT). Nearly 70% (n = 149) of the intervention participants completed treatment and post-intervention assessments; 53 (80%) waitlist-controls completed post-intervention assessments. Estimated effect sizes for depression and dysfunction were 0.60 and 0.55 respectively, comparing BATD participants to all controls and 0.84 and 0.79 respectively, compared to BATD controls only. Estimated effect sizes for depression and dysfunction were 0.70 and 0.90 respectively comparing CPT participants to all controls and 0.44 and 0.63 respectively compared to CPT controls only. Using a permutation-based hypothesis test that is robust to the model assumptions implicit in regression models, BATD had significant effects on depression (p = .003) and dysfunction (p = .007), while CPT had a significant effect on dysfunction only (p = .004).
Both interventions showed moderate to strong effects on most outcomes. This study demonstrates effectiveness of these interventions in low resource environments by mental health workers with limited prior experience.
ClinicalTrials.Gov NCT00925262. Registered June 3, 2009.
Survivors of systematic violence, including torture, are at risk of multiple poor mental and physical health outcomes. A meta-analysis of 181 studies of mental health outcomes in conflict-affected or displaced populations found that report of torture increased the odds of PTSD and depression . This meta-analysis and a study of Norwegian immigrants from multiple countries found physical torture the most robust predictor of mental distress ,. Iraqi refugees in the US who reported torture had 4.32 and 2.08 times the odds of mental distress and physical health problems respectively compared to those who had not experienced torture . Though less prevalent than PTSD or depression, generalized anxiety is also frequently reported among survivors of torture -.
A recent review identified 40 treatment studies for survivors of torture and other systematic violence including 11 randomized controlled trials (RCTs) . Only five RCTs (and three quasi-experimental studies) were from low or middle income countries and only one (quasi-experimental study) was in the Middle East. Most treatments were delivered outside clients’ country of origin, focused on posttraumatic stress, and consisted of Cognitive Behavioral Therapy (CBT), Narrative Exposure Therapy (NET), multidisciplinary rehabilitation, or outpatient psychiatry. Effect sizes ranged from 0.51-3.46 for PTSD and 0.56-2.30 for depression .
Systematic violence, both physical and psychological, is frequent in Iraqi Kurdistan’s recent history. Saddam Hussein’s government conducted a campaign of persecution and genocide (‘the Anafal’) against Iraqi Kurdistan including bombing, chemical warfare, and forced dislocations ,. Between 1986-9, 50,000-100,000 persons were killed and 4,000 villages destroyed -. A chemical attack on Halabja city killed 5,000 civilians ,,. Arbitrary imprisonment, torture, and mass killings were common ,.
Kurdistan is now an autonomous region within Iraq, composed of three governorates: Dohuk, Erbil, and Sulaimaniyah. At the time of writing, the region is once again in conflict with substantial nearby areas under control of the Islamic State of Iraq and the Levant (ISIL). At the time of the study Kurdistan was experiencing relatively little violence. However, a qualitative study conducted during the year prior to trial commencement found that those who lived through the 1980s suffer a range of problems that they attribute to the trauma experienced during that time, to their current situation, and to their perception of how they are treated by others. Many respondents complained of being treated poorly by the community and even family; that the suffering and efforts of those who had experienced violence under the Saddam regime were not respected. Their current problems included poverty, discrimination, stigma, mental distress, and reduced social, physical, and economic function .
The study’s primary objective was to assess the acceptability, feasibility, and effectiveness of scalable mental health treatments for survivors of systematic violence. We conducted a randomized controlled trial (RCT) in the governorate of Erbil and Sulaimaniyah (including the city of Baquba) comparing Behavioral Activation Treatment for Depression (BATD) and Cognitive Processing Therapy (CPT) to a waitlist-control condition among survivors of systematic violence. Interventions were provided by community mental health workers (CMHWs) in government primary health care clinics. The primary outcome measures were depression and functional impairment. The decision to focus on depression as the primary mental health outcome was based on a prior brief qualitative study identifying current problems of survivors of systematic violence. That study suggested that among survivors’ the most salient current psychosocial problems were related to depression while other problems, such as PTSD symptoms, anxiety and traumatic grief, were less so .
The original study design included a single trial of three interventions - two evidence-based treatments: Behavioral Activation Treatment for Depression (BATD) and Cognitive Processing Therapy (CPT), and a third treatment condition consisting of a basic supportive counseling program. The trial was to extend across all three governorates of Suleimaniyah, Erbil, and Dohuk, based on a misconception that the populations and situations of the governorates were sufficiently similar. However, we subsequently realized that there are important differences between the populations in Dohuk governorate and the rest of Kurdistan. These differences include language, with the Dohuk governorate speaking a different Kurdish dialect than the other parts of Kurdistan, degree of religiosity, with Dohuk being more religious and politically conservative than the other parts of Kurdistan, and the types of trauma exposures given the proximity of Dohuk to the Turkish border. We therefore changed the design to two separate trials: a trial of CPT and BATD in Erbil and Sulaimaniyah governorates only and a separate trial of basic supportive counseling in Dohuk governorate only (the latter is not reported here).
The two evidence-based treatments, BATD and CPT, were implemented in clinics throughout Erbil and Sulaimaniyah governorates. Our original study design had each intervention providing treatment and control participants at a 3:1 ratio, which would have allowed us to pool all controls (including those from the Dohuk region) resulting in a 1:1 allocation of treatment to controls for each treatment condition. With the decision to evaluate the basic supportive counseling program in the Dohuk region as a separate trial (not reported here), the clinics in Erbil and Sulaimaniyah formed the three-arm RCT reported here: BATD, CPT, and waitlist control. This change was made prior to data collection but after design and budgeting.
Intervention training and supervision was based on the Apprenticeship Model described elsewhere . Briefly, US-based trainers provided a two-week training in BATD or CPT to CMHWs and local supervisors. Supervisors then gave ongoing training and supervision to CMHWs while receiving weekly training and oversight from US-based trainers by phone, Skype, and email. Interventions were provided on a rolling basis between June 2009 and August 2010. The final post-intervention assessment was conducted in January 2011.
Based on a prior qualitative study with Kurdish torture survivors , we designated depression symptoms and dysfunction as the primary study outcomes. Other problems identified in that study formed secondary outcomes: posttraumatic stress, anxiety, and traumatic grief.
Instrument development and testing
Qualitative study data were used to adapt the Hopkins Symptom Checklist for Depression and Anxiety (HSCL-25) ,, the Harvard Trauma Questionnaire (HTQ) , and the Inventory of Traumatic Grief , to measure symptoms of depression, anxiety, posttraumatic stress and traumatic grief. Adaptation included adding 13 locally relevant symptoms. Table 1 presents all the mental health symptoms included in the final instrument, identifying which are from the standard measures and which came from the qualitative study. Participants reported symptom frequency for the prior two-weeks using an ordinal scale of 0 (never) to 3 (always). Analyses of intervention impact on mental health outcomes used mean item scores for each scale, therefore also ranging from 0-3.
The study instrument also included locally developed function scales for men and women based on frequently mentioned activities in the qualitative study that men/women do to care for self, family, and community. Respondents rated difficulty on an ordinal scale of 0 (‘no more difficulty than most men/women of the same age’) to 4 (‘frequently unable to do the activity’). Analyses of intervention impact on dysfunction used mean item scores for this scale, therefore also ranging from 0-4. Table 2 presents the items included in the function scales for men and women.
Instrument reliability and validity were tested for all outcomes among local survivors of systematic violence (N = 128). Interviewees were taken from lists of torture survivors provided by a local former prisoners association. Persons on these lists had previously been contacted by the interviewers and asked whether they would agree to be interviewed. For the purpose of testing they were asked whether they felt they were depressed, anxious, or experienced excessive fear (the latter term describing symptom similar to posttraumatic stress). Another adult in the house was asked the same questions about the survivor. Those survivors for whom they and the other adult agreed as to the presence or absence of these problems were selected from the lists for interview. This study was done in the year prior to the trial commencement and since the study criteria were the same some of the participants were also subsequently trial participants. Cronbach’s alphas ranged from .725 to .928, indicating adequate internal reliability. Pearson correlation coefficients for test-retest reliability (repeat interviews were conducted 1-3 days later) ranged between .728 and .864. Criterion validity was assessed using methods described elsewhere . Briefly, criterion validity was assessed by comparing the previous statements of the survivors and others as to whether the survivors had depression, anxiety or excessive fear with the results of the instrument measuring the similar concepts of depression, anxiety, posttraumatic stress, and traumatic grief. A high level of agreement would be expected if people can accurately recognize the presence of these problems and if the instrument has criterion validity. Criterion validity was supported for all scales among men but only for posttraumatic stress symptoms among women. However, based on the results on the other tests of validity and reliability measures by sex we decided to retain the measures. Another reason for retention was that we suspected problems with the criterion validity testing procedure. In previous studies we have found that instruments tend to perform either well or poorly across most tests, so poor criterion validity in the face of adequate performance on other measures was unusual. Our local partners speculated that criterion validity was poor among women because their husbands may not be good judges of their wife’s mental state. Detailed descriptions of instrument development are provided elsewhere .
The authors consulted torture, trauma, and cross-cultural mental health experts and local stakeholders and mental health providers. Experts disagreed on whether an intervention could address depression without addressing trauma. The PI (PB) decided to evaluate both types of interventions by selecting BATD (depression only treatment) and CPT (trauma and depression).
Two evidence-based treatments were included in this study. The process to adapt both interventions to the local context was iterative, continuing throughout training and early implementation, with feedback sought and incorporated from multiple sources. Both interventions were adapted for low literacy and administration by paraprofessionals. This was the first time BATD or CPT had been adapted in this way.
Brief behavioral activation treatment for depression (BATD)
BATD is an empirically supported psychotherapy for depression. It is published in a 12 session format  which is briefer than other variants of behavioral activation which often exceed 20 sessions  and focuses on strategies to engender structured engagement in healthy and positive values-based behaviors -. BATD has demonstrated efficacy in eight RCTs in diverse populations -. Preliminary evidence suggests that the full version of BA may also reduce PTSD symptoms -.
The core content of BATD is based on helping individuals plan for and engage in positive activities on a daily basis based on the values and goals of that individual in multiple life areas (e.g., relationships, career, and spirituality). Engagement in these activities is initially supported by the structure of the program and reinforced by the therapist, but the reinforcement becomes more intrinsic as the activities lead to more positive life experiences and the satisfaction that comes with living according to one’s own values and goals. The treatment was highly consistent with the original treatment manual but with two types of adaptations: First, changes based on cultural issues including a) consideration of societal expectations regarding acceptable and unacceptable activities and b) modification of the discussion of values to be less individual-focused and more collective, focused on the participant’s place in the larger society. Second, changes to address patient adversities including limited language/writing proficiency and extreme poverty. These included a set of stickers developed for patients to use in place of written monitoring of activities, and focus on identifying low cost easily accessible activities to reduce financial barriers.
Cognitive processing therapy (CPT)
CPT is a12-session psychotherapy that includes cognitive restructuring (i.e., identifying, challenging, and modifying maladaptive beliefs) and emotional processing of traumatic events (i.e., using a writing narrative to help clients identify and feel their emotions about their worst traumatic events). Cognitive restructuring initially focuses on rigid or inaccurate beliefs about the trauma itself (i.e., reasons why it happened or what could have prevented). It then shifts to overgeneralized beliefs about the self or other that have been affected by the trauma in the domains of safety, trust, power/control, esteem, and intimacy. The ultimate goals of treatment are for clients to be able to approach (vs. avoid) their feelings about the trauma and to modify rigid, inaccurate, or overgeneralized trauma-related beliefs to be more flexible, accurate, and adaptive. Clients are taught these skills throughout the course of treatment and practice outside of session (i.e, homework) is a therapy expectation. CPT was designed to reduce PTSD symptoms in sexual violence survivors . Multiple studies have examined CPT’s effectiveness among female rape victims -; child sexual abuse survivors ; combat veterans ,; physical assault survivors ; and refugees . CPT has proven effective in reducing PTSD and depression symptoms compared to controls ,,, and reducing PTSD compared to minimal attention ,. Improvements in PTSD and depression symptoms among rape survivors are comparable to Prolonged Exposure Therapy . Unlike the current study previous studies used PTSD diagnosis as an inclusion criterion.
A full description of the adaption of CPT to the Kurdish population can be found elsewhere . Briefly, while the essential elements of CPT were not changed, we adapted training materials to the local culture and situation. Throughout the training manual, reference to American culture-specific examples or explanations were changed to examples relevant to Kurdistan. The final sessions of CPT focus on themes considered related to the experienced trauma: safety, trust, power, esteem and intimacy. Through discussions with the local CMHWs and mental health professional staff it became clear that no direct translations for esteem or intimacy were available in the Kurdish language so the alternative themes of respect and caring were identified that were more culturally appropriate and relevant to the study population. We also adapted the homework assignments to account for the limited literacy levels of the study population. We reduced the complexity and length of all written material and included images as visual cues for the skills being to taught (e.g., reducing the number of questions to challenge maladaptive beliefs from 10 to 5, using images of emotions to cue clients to identify their feelings in relation to a thought). For clients who were illiterate, we also made use of skills some CMHWs had previously learned from our partner, Heartland Alliance. These included rote memorization drills on the skill/assignment for clients to practice over the next week, using mobile phones to record homework, and involving family members as scribes (if there was a family member that the client trusted. No other content specific changes were made to the standard CPT protocol.
Waitlist control condition
Study participants randomized to the control condition were informed that they would be waitlisted for treatment and then offered the treatment after approximately 5 months regardless of their re-interview results. During the wait period, CMHWs contacted controls monthly to enquire generally about the severity of their symptoms, particularly that they were not a danger to self or others, as a safety check. Controls were instructed to contact the CMHWs if symptoms substantially worsened, for assessment for possible transfer and referral to a psychiatrist or a torture treatment center in Sulaimaniyah.
The study was implemented in two governorates of Iraqi Kurdistan; Erbil and Sulaimaniyah. Both treatment conditions, BATD and CPT, were implemented in both governorates. Assessments, obtaining informed (verbal) consent, and treatment were performed by CMHWs at 14 Ministry of Health primary health clinics and one outpatient clinic, all in rural areas of the two governorates. CMHWs were nurses, pharmacist assistants, or physician assistants employed by the clinics. All had completed high school and had varying amounts of post graduate and/or job specific training. Criteria for selection were that they worked in government clinics in rural areas, that they had previously been trained by our partner - Heartland Alliance International in basic supportive counseling, and that they were seeing clients before the study. The CMHWs in the study were 7 women and 13 men, aged between 30 and 50 years. Each clinic provided private space for screening and treatment.
Study eligibility screening and randomization
Recruitment occurred from May 2009 to June 2010. Participants were identified through referral by doctors and nurses at the participating Ministry of Health primary care clinics and through collaboration with former prisoner organizations who notified their members that the services were available. Eligible persons were survivors of systematic violence living in the governorates of Erbil or Sulaimaniyah, aged 18 or over, fluent in Sorani Kurdish, reported significant depression symptoms on the adapted HSCL-25, had no current psychotic symptoms or active suicidality, and appeared mentally competent to consent. ‘Survivor of systematic violence’ was defined as experiencing and/or witnessing physical torture, imprisonment (where torture and other abuse were frequent), and/or military attacks. The latter included gas attacks in the city of Halabja. Many participants were illiterate; half reported no education.
Inclusion in the trial was based on symptom presentation using an adaptation of the HSCL-25 that included the 15 standard depression items plus five local depression-like symptoms identified during the qualitative study. Respondents reported how frequently they experienced each symptom in the prior 2 weeks ranging from 0 to 3. To identify participants with sufficient depression severity warranting treatment, the inclusion criteria included a score of 2 or 3 (equivalent to experiencing a symptoms often or always) on at least one of the DSM-IV A Criteria related to presence of depressive symptoms or anhedonia (crying or feeling depressed most of the time, loss of interest in sex or things generally, or inability to enjoy festivals and celebrations) and a total symptoms score of at least 20. The choice of 20 was arbitrary as we had no prior data on this population. It was chosen because the depression instrument had 20 questions. Therefore a score of 20 or more would indicate symptomatology on a significant proportion of the instrument (at least 7 symptoms). If eligible, the CMHW obtained informed verbal consent and explained that participants would be randomized to immediate treatment (BATD or CPT) or waitlist. If a person consented the CMHW opened a sealed envelope attached to the consent form containing the participant’s assignment. Exclusion criteria were inability to be interviewed due to a cognitive or physical disability, or severe suicidal ideation or behavior.
We used a two-tier randomization process. First 20 CMHWs who worked at primary clinics throughout rural Erbil and Sulaimaniyah governorates were randomized to receive training in either BATD (n = 11) or CPT (n = 9). This resulted in both treatments (BATD and CPT) being equally distributed across both governorates. The second-tier randomization happened at the level of the study participant. Study participants were randomized to study condition (treatment or wait-list control) by the CMHW they saw at their local primary care center where they went for treatment. The CMHWs received twenty participant IDs randomly assigned to intervention or control in the ratio of 3:1 of treatment to wait-controls. Randomization of CMHWs and participant IDs was done by JB using Stata’s randomization function. Investigators kept a master list of each study ID’s assignment for checking randomization fidelity.
The study design called for the study instrument to be re-administered by supervisors and CMHWs approximately three to five months after recruitment, following treatment completion. Due to logistical challenges resulting in clients taking longer than expected to complete the treatment (i.e. re-scheduling of sessions due to work or travel), the mean follow up time was 5.5 months, with a range of 1.6-15.5 months. CMHWs or supervisors blind to participants’ treatment status did 197 (85%) of the interviews; 35 (15%) were implemented by un-blinded CMHWs. The latter group included participants who terminated treatment and refused further contact. Rather than forgo assessment, the treating CMHW did the interview.
Sample size was based on a 20% greater reduction in mean depression score in each intervention compared with all controls, power = 0.80, and alpha = 0.05. This yielded 85 participants in each arm, increased to 106 anticipating a 25% drop-out rate. The sample size for each treatment condition was met, but the control sample was smaller than originally planned due to the removal of the participants from the Dohuk region. A post-hoc power analysis using a simplified multiple regression model identified power greater than 0.80 for the primary outcomes of depression and dysfunction comparing CPT to all controls and BATD to all controls. A similar analysis to examine power to detect differences when comparing each treatment to their own controls identified insufficient power (0.40) only for CPT compared to CPT controls for the depression outcome.
All analyses were conducted on the full intent to treat sample and based on change in mean scale scores between baseline and post-assessment. Primary outcomes were mean depression and dysfunction scores. Secondary outcomes were mean anxiety, post-traumatic stress, and traumatic grief scores.
We first compared BATD and CPT to all controls, per the original study design. This relies on the homogeneity assumption that each patient’s outcome is a random draw from a common distribution independent of site. We had no reason to believe that this assumption would be violated because we randomly allocated CMHWs to interventions and recruitment and randomization were consistent across sites. However, a post-hoc analysis of participant characteristics suggested site-specific differences between treatment arms at baseline, challenging the homogeneity assumption. We therefore did a second analysis comparing BATD only to controls generated by the BATD CMHWs (BATD-controls) and CPT only to controls at generated by CPT CMHWs (CPT-controls). This is less precise due to a smaller sample size but more robust by not making the homogeneity assumption. By way of full disclosure we report both analyses.
To estimate treatment effects we used maximum likelihood mixed-effect regression models with a robust variance estimator. All analyses controlled for participant sex, age, marital status, and disability. Additional variables that differed between treatment and control at baseline or that predicted change in outcome were included as covariates (p < 0.10). Multiple imputation by chained equations accounted for missing scale items and follow up scores among those lost to follow up . Clustering at the levels of CMHW and governorate were reviewed.
Effect sizes reflecting regression adjustments were calculated using Cohen’s d , which represents the mean differences across the arms standardized by the baseline pooled standard deviation. Effect sizes are equivalent to a Z-score of a standard Normal distribution (i.e. effect size of 1.0 would mean the mean therapy participant’s symptom score is 1.0 standard deviation above the mean waitlist participant’s symptom score). Regression diagnostics included calculating and assessing the normality of standardized residuals at the CMHW and individual level, as well as for the whole model.
A sensitivity analysis was done to assess whether there was any bias in the results due to inclusion of participants assessed by staff unblinded to treatment condition. For this analysis, we analyzed the primary outcomes of depression and dysfunction without the approximately 15% of the sample that was assessed at follow up by study staff familiar with their treatment allocation.
We conducted a third analysis to independently test the null hypothesis of no effect of treatment by applying Rosenbaum et al.’s permutation-based method,  which has been applied to cluster randomized trials of mental health interventions by Small et al. . This general method has the advantage of not needing to rely on regression model assumptions nor the aforementioned homogeneity assumption. We used data from all the participants randomized to BATD or CPT and their respective controls. This last analysis was done to examine whether the study conclusions remain valid even without the homogeneity assumption and the standard assumptions implicit in the regression models of the first two analyses (Additional files 1 and 2).
All analyses were conducted using Stata 12.0 and R ,. The study was approved by Johns Hopkins University’s Internal Review Board and University of Sulaimaniyah College of Medicine’s Ethical Committee.
Of 281 participants, 215 were randomly assigned to intervention (114 to BATD and 101 to CPT) and 66 to waitlist control (Figure 1). Seven BATD participants (6%) never began treatment and 25 (28%) dropped out before completion (nine sessions). Those who did not begin or dropped out of BATD were more likely to be from the Sulaimaniyah governorate, have no education and be self-employed or have irregular work compared with those who completed treatment. Six CPT participants (6%) did not start treatment and 15 (21%) dropped out before completion (also nine sessions). Those who did not begin or dropped out of CPT were more likely to be male and married compared with those who completed treatment. Ten (15%) controls dropped out and 2 (3%) could not be located at follow up. Those controls who were not followed up were more likely to be male, living in Sulaimaniyah governorate, and have at least some education compared with controls who were followed up. Participants who dropped out of the trial after having started the treatment rarely gave reasons beyond not wanting to continue. One CPT and 2 BATD participants left to seek psychiatric help. One CPT participant moved away, one was referred for psychosis, and one left after being verbally abused by her husband for getting treatment. This was the only significant harm or unintended effect reported in the study. One control was referred to a psychiatrist for worsening symptoms.
A review of demographic characteristics (Table 3) identifies that the proportion of females is smaller among BATD-site controls than the BATD group; the opposite is true for CPT and CPT-site controls. There were also differences in marital status across the groups with the proportion of widows smallest in the BATD group and the proportion of single/divorced the smallest in the CPT control group. Employment status also varied by group, with the CPT controls having the highest proportion of not working participants and the BATD participants having the highest proportion of self-employed or irregular workers.
Table 4 presents baseline scores for treatment groups and controls. Mean dysfunction and traumatic grief scores are higher among CPT-site participants. Women had higher mean scores across all scales.
Treatment effect estimates are presented in Tables 5 and 6. We present CPT and BATD each compared to all controls per our original study design in Table 5. We present CPT to CPT-controls and BATD to BATD-controls in Table 6. Effect sizes for both analyses were medium to large. Depression effect sizes were 0.60 and 0.84 for BATD and 0.70 and 0.44 for CPT compared to all controls and BATD/CPT-specific controls respectively. Depression effect sizes were only statistically significant for CPT compared to all controls and for BATD compared to BATD-site controls. For dysfunction, effect sizes ranged from moderate to large: 0.55 or 0.79 for BATD and 0.90 or 0.63 for CPT based on all controls and BATD/CPT-controls respectively. All were statistically significant. Sensitivity analyses assessing potential bias associated with unblinded follow-up assessments identified small differences in the effect sizes for the primary outcomes but the conclusions were not changed (results not presented). We generated models with and without governorate as a cluster variable and with and without it as a covariate and all 4 models gave very similar results for the outcomes. Therefore the most parsimonious model (the one we used) controlled for clustering within CMHW only.
Effect sizes for secondary outcomes were moderate to large except for BATD compared to all controls (small effect) for traumatic grief and statistically significant except for BATD compared to all controls for posttraumatic stress and traumatic grief.
The third analysis, to independently test the null hypothesis of no treatment effect, identified statistically significant effects for BATD for both primary outcomes, i.e., for depression (p = .003) and dysfunction (p = .007), and for CPT for the outcome of dysfunction only (p = .004).
We studied the impact of BATD and CPT on the primary outcomes of depression and dysfunction and the secondary outcomes of anxiety, posttraumatic stress and traumatic grief symptoms among survivors of systematic violence in Kurdistan. Both interventions were adapted to address local treatment issues including illiteracy and restrictions on women traveling and being treated by male CMHWs. Our original design compared each intervention arm with all controls. However, due to baseline differences between study arms, we also compared BATD to BATD-controls only and did the same for CPT. While estimated effect sizes varied with the type of controls used, both interventions showed moderate to strong impacts on the primary outcomes (depression and dysfunction) in both analyses. The third analysis, which tested the null hypothesis of no treatment effect using a permutation-based method with added robustness to model assumptions, provides additional evidence for BATD for both primary outcomes, and for CPT for the outcome of dysfunction.
Improvement in symptom severity was also evidenced in the waitlist-control group. This is not unusual, particularly given the cyclical nature of mental health symptoms and the expectation that, for some, we may have picked them up at or near the peak of their symptom severity as a consequence of the symptom-level criteria requirement for inclusion in the trial. Similar improvements among waitlist controls have been seen in other controlled trials of psychotherapies in low- and middle-income countries ,.
We consider the comparisons to BATD and CPT specific controls (as opposed to the analyses using all the controls combined) as more likely to reflect true intervention impacts. On this basis, effect sizes for CPT on primary outcomes were moderate and moderate to large for secondary outcomes. BATD had a large effect on primary outcomes and moderate effects on all secondary outcomes. Since BATD focuses on behavioral change rather than trauma, this also answered our question of whether a trauma-based approach was necessary to address depression in this trauma-affected population. In terms of the clinical significance of these findings, the study participants started the trial with a mean depression score of about 1.6 indicating that on average, they experienced all the symptoms of depression between a little bit and a moderate amount of the time in the prior 2 weeks. After participating in the intervention, the CPT and BATD participants’ mean scores were all below 1.0, indicating they experienced all the symptoms less than a little bit of the time.
The decision to use depression severity, rather than PTSD symptoms, as the primary mental health outcome was made based on an earlier qualitative study  that identified the current priority problems among the target population. RCTs with survivors of systematic violence do not usually focus on depression. One review identified studies that also evaluated and found significant impacts on depression, albeit smaller than PTSD . One study of CBT among ex-detainees (including many torture survivors) found an effect size of 2.0 . Studies of NET for asylum seekers and refugees have produced conflicting results: an effect size of 1.56 in one study  and no effect in another . Studies of general counseling and a multidisciplinary intervention have found no effect ,. The effect sizes we found for depression are smaller than some of the trials quoted above ,; however, those trials were all conducted in clinics specifically treating torture survivors and refugees in high-income settings.
RCTs including survivors of systematic violence, including torture, typically focus on PTSD symptoms. Cognitive behavioral therapies ,,,, NET , and general psychosocial counseling , have all demonstrated impact on PTSD symptoms. Effect sizes for cognitive-behavioral and testimony interventions are high, typically 1-3 ,-,. There are mixed findings for the effectiveness of general counseling suggesting that it can produce some improvement ,. In our trial, both interventions had a moderate effect on PTSD symptoms.
The generalizability of our conclusions to other populations and contexts is an area for future research. A study by the same researchers and clinical team that used the same methods found much greater effect sizes among survivors of sexual violence in Democratic Republic of Congo , suggesting effectiveness may vary by culture and context.
Follow-up occurred within a month following the intervention, preventing evaluation of long-term treatment effects. The study design called for post-assessment three to five months after recruitment, following treatment completion but many clients took much longer than expected to finish treatment so that mean follow up time was 5.5 months. However, while this range may have impacted the results of the trial compared to the original design, the results are therefore probably closer to the results that would be achieved in normal programming. Participants were not blinded to their own treatment/control status. Also, we cannot determine how much of the difference between intervention and control groups is due to regularly meeting with CMHWs regardless of intervention content. 35 out of 232 follow-up interviews were not blinded and therefore subject to possible bias although sensitivity analysis suggests that this was not significant. Instruments showed adequate validity and reliability, however criterion validity was not demonstrated for female respondents, except for PTSD.
Most effect sizes were significant despite a smaller control group than planned. Non-significant effects were moderate in size with upper confidence interval (CI) limits near zero, suggesting that lack of significance was a sample size issue. The exception was BATD compared to all controls for traumatic grief; the effect size was small and the upper CI limit clearly beyond 0, suggesting no appreciable effect.
The number of participants who dropped out from the trial before beginning treatment was relatively small (N = 7 for BATD, N = 6 for CPT). The dropout rates among those who started treatment but did not complete (Figure 1) were 28% and 21%, respectively for BATD and CPT. Drop out rates in CPT trials in high resource countries range from 17-25% (40, 43-46) and 10-25% (30,32,65) in BATD outpatient studies . The similarity between overall non-completion rates in the control and intervention arms (particularly CPT) suggest that the cause is not related to treatment content but to other factors, such as an unwillingness to be contacted regularly.
We lack specific information on the timing and extent of the trauma experiences of the study participants that makes it impossible to link past trauma experiences to current mental health symptoms. Having this information would have allowed a more nuanced investigation of treatment effects, including possible differences by treatment type, by severity of trauma and by time since it occurred.
This study supports the effectiveness of two psychotherapies for survivors of systematic violence in rural Kurdistan by workers with limited prior experience. Trainers adapted both treatments for illiterate participants. Stigma associated with mental problems was a major issue; families and individuals frequently resisted treatment fearing family reputation and marriageability would be affected. Despite these challenges, the trial demonstrated that CMHWs could implement BATD and CPT. The similarity in drop-out rates between this sample and those in high-resource countries combined with the robust treatment effects suggests that locally adapted CPT and BATD are useful mental health treatments in this setting.
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This study was solely funded by the USAID Victims of Torture Fund (VOT). VOT was not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. We particularly thank VOT for their commitment to evidence-based programming as the basis for effective services.
The authors declare that they have no competing interests.
PB leader of the study (PI), study design, training of interviewers, supervision of field-based data collection, oversaw each study phase, manuscript preparation. JB study design, training of interviewers, data management, statistical design and analysis, manuscript preparation. NA study design, advice on local implementation, local IRB review, and manuscript preparation. GZ supervision of field research activities and manuscript preparation. TK supervision of field research activities and manuscript preparation. SM assisted with statistical design and analysis, manuscript preparation. DK CPT adaptation, therapist training, and clinical oversight. Manuscript preparation. KL CPT adaptation, therapist training, and clinical oversight. Manuscript preparation. CL BATD, therapist training, and clinical oversight. Manuscript preparation. SP BATD adaptation, therapist training, and clinical oversight. Manuscript preparation. LM study assessment and intervention selection, and manuscript preparation. SS background research, literature review and manuscript preparation. MR statistical design and interpretation, and manuscript preparation. All authors read and approved the final manuscript.
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Bolton, P., Bass, J.K., Zangana, G.A.S. et al. A randomized controlled trial of mental health interventions for survivors of systematic violence in Kurdistan, Northern Iraq. BMC Psychiatry 14, 360 (2014) doi:10.1186/s12888-014-0360-2
- Trauma treatment
- Task sharing
- Evidence-based treatments