Table 4 Suicide deaths and rates over time by mood stabilizer treatment over briefer time periods (0–90 and 0–180 days)
A. Intent-to-Treat Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|
| Â | All Patients Initiating Treatment (Intent-to-Treat Cohort) | Â | Â | |||||
| Â | Patients Initiating Lithium | Patients Initiating Valproate | Â | Â | ||||
Follow-up Time | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Conditional Odds Ratio (95% CI) | Rate Ratio |
0-90 days | 21194 | 18 | 9.35 | 21194 | 19 | 9.87 | 0.95a (0.50-1.81) | 0.95 |
0-180 days | 21194 | 39 | 10.20 | 21194 | 25 | 6.54 | 1.56b (0.94-2.58) | 1.56 |
B. Findings Stratified by Initial Treatment Status | ||||||||
| Â | During Exposure to Initial Treatmentc | Â | Â | |||||
| Â | Patients Initiating Lithium | Patients Initiating Valproate | Â | Â | ||||
Follow-up Time | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Conditional Odds Ratio (95% CI) | Rate Ratio |
0-90 days | 21194 | 15 | 10.00 | 21194 | 17 | 11.30 | 0.88d (0.44-1.77) | 0.88 |
0-180 days | 21194 | 17 | 7.99 | 21194 | 17 | 7.93 | 1.00e (0.51-1.96) | 1.01 |
| Â | During Period After Stopping/Modifying Initial Treatmentf | Â | Â | |||||
| Â | Patients Initiating Lithium | Patients Initiating Valproate | Â | Â | ||||
Follow-up Time | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Odds Ratio (95% CI) | Rate Ratio |
0-90 days | 11227 | 3 | 6.98 | 11185 | 2 | 4.75 | 1.49g (0.25-8.95) | 1.47 |
0-180 days | 16138 | 22 | 13.00 | 15958 | 8 | 4.78 | 2.72h,i (1.21-6.11) | 2.72 |