Table 3 Suicide deaths and rates over time by mood stabilizer treatment
A. Primary Analysis (Intent-to-treat, 0–365 days) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Â | All Patients Initiating Treatment (Intent-to-Treat Cohort) | Â | Â | |||||
| Â | Patients Initiating Lithium | Patients Initiating Valproate | Â | Â | ||||
Follow-up Time | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Conditional Odds Ratio (95% CI) | Rate Ratio |
0-365 days | 21194 | 56 | 7.27 | 21194 | 46 | 5.98 | 1.22a (0.82-1.81) | 1.22 |
B. Findings Stratified by Initial Treatment Status (0–365 days) | ||||||||
| Â | During Exposure to Initial Treatmentb | Â | Â | |||||
| Â | Patients Initiating Lithium | Patients Initiating Valproate | Â | Â | ||||
Follow-up Time | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Conditional Odds Ratio (95% CI) | Rate Ratio |
0-365 days | 21194 | 18 | 6.71 | 21194 | 21 | 7.68 | 0.86c (0.46-1.61) | 0.87 |
| Â | During Period After Stopping/Modifying Initial Treatmentd | Â | Â | |||||
| Â | Patients Initiating Lithium | Patients Initiating Valproate | Â | Â | ||||
Follow-up Time | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Patients, No. | Suicide Deaths, No. | Rate (per 106 person-days) | Odds Ratio (95% CI) | Rate Ratio |
0-365 days | 19494 | 38 | 7.58 | 19362 | 25 | 5.05 | 1.51e (0.91-2.50) | 1.50 |