Statin use and risk of depression: a Swedish national cohort study

BMC Psychiatry

Table 3 Adjusted ORs from multivariable logistic regression for association between statin prescription and subsequent diagnosis of depression between 2006-2008, by increasing age group ( n = 4,607,990)

	Age ≥40 yrs			Age ≥50 yrs			Age ≥60 yrs			Age ≥70 yrs
	OR ^a	95% CI	p-value	OR ^a	95% CI	p-value	OR ^a	95% CI	p-value	OR ^a	95% CI	p-value
Statin prescriptions
Any statin	0.95	0.91-0.99	0.016	0.91	0.87-0.95	<0.001	0.85	0.81-0.89	<0.001	0.81	0.76-0.87	<0.001
Simvastatin	0.93	0.89-0.97	0.001	0.90	0.86-0.94	<0.001	0.85	0.81-0.90	<0.001	0.82	0.76-0.87	<0.001
Pravastatin	0.90	0.74-1.09	0.268	0.84	0.69-1.04	0.104	0.80	0.64-1.01	0.061	0.72	0.54-0.96	0.026
Fluvastatin	0.98	0.65-1.46	0.914	0.91	0.59-1.39	0.660	0.89	0.55-1.43	0.662	1.03	0.60-1.78	0.906
Atorvastatin	1.11	1.01-1.22	0.032	1.04	0.94-1.16	0.427	0.95	0.84-1.07	0.384	0.93	0.80-1.10	0.412
Rosuvastatin	1.21	0.92-1.60	0.177	1.18	0.88-1.60	0.274	1.10	0.75-1.60	0.635	1.21	0.71-2.04	0.485

CI = confidence interval; OR = odds ratio.
^aThe model includes prescription of statin medication (any statin, and by individual statins) and the following variables as covariates: gender, age (40-49, 50-59, 60-69, 70+), marital status, education (three levels), family income (quartiles), hospitalisation for cardio-pulmonary disease, hospitalisation for alcoholism, hospitalisation for coronary heart disease, and region (large cities, Southern, Northern).

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