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Table 3 2 × 2 ANCOVA (group x genotype) matched for age, gender and protocol

From: The BDNFp.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse

 

MNI eCoordinates

  

Brain region

x

y

z

Brodmann Area

Cluster Size (Voxels)

Z-statistic

Cluster p-value

Ancova analyses:

Main effect of group

Left lateral prefrontal cortex

−43

48

−17

11

125

3.64

<0.001

Main effect of genotype

Left lateral prefrontal cortex

−43

48

−17

11

129

3.66

<0.001

Left occipital lobe

−32

−88

3

19

58

3.52

<0.001

Main effect of CTQ total score

Left parahippocampal gyrus

−26

−24

−25

35

958

4.16

<0.001

Genotype x alcohol group interaction

Left lateral prefrontal cortex

−43

48

−17

11

32

3.33

<0.001

CTQ total score x genotype interaction

Fusiform gyrus

39

−59

−21

NAf

890

3.69

<0.001

POST-HOC t-tests g:

Genotype post-hoc t-test: Val/Val > Val/Met + Met/Met

Left lateral prefrontal cortex

−40

12

28

9

29

3.24

<0.001

Within-group genotype t-test (AUD): Val/Val > Val/Met + Met/Met

Left lateral prefrontal cortex

−38

13

28

9

17

3.18

<0.001

Between-group genotype t-test (Val/Val): HC > AUD

Left lateral prefrontal cortex

−20

23

−30

11

332

3.88

<0.001

Within-group CTQ t-test ( Val/Met + Met/Met ): low > high CTQ

Middle Occipital gyrus

−17

−93

14

18

708

4.78

<0.001

Within-group CTQ t-test (Val/Val): low > high CTQ

Middle frontal gyrus

−27

25

−18

NA

708

4.06

<0.001

  1. eMNI = Montreal Neurological Institute CoordinateSs. fNot applicable. gBesides the CTQ t-tests, all post-hoc t-tests were analysed with CTQ as a covariate of interest.