| MNI eCoordinates |  |  | ||||
---|---|---|---|---|---|---|---|
Brain region | x | y | z | Brodmann Area | Cluster Size (Voxels) | Z-statistic | Cluster p-value |
Ancova analyses: | |||||||
Main effect of group | |||||||
Left lateral prefrontal cortex | −43 | 48 | −17 | 11 | 125 | 3.64 | <0.001 |
Main effect of genotype | |||||||
Left lateral prefrontal cortex | −43 | 48 | −17 | 11 | 129 | 3.66 | <0.001 |
Left occipital lobe | −32 | −88 | 3 | 19 | 58 | 3.52 | <0.001 |
Main effect of CTQ total score | |||||||
Left parahippocampal gyrus | −26 | −24 | −25 | 35 | 958 | 4.16 | <0.001 |
Genotype x alcohol group interaction | |||||||
Left lateral prefrontal cortex | −43 | 48 | −17 | 11 | 32 | 3.33 | <0.001 |
CTQ total score x genotype interaction | |||||||
Fusiform gyrus | 39 | −59 | −21 | NAf | 890 | 3.69 | <0.001 |
POST-HOC t-tests g: | |||||||
Genotype post-hoc t-test: Val/Val > Val/Met + Met/Met | |||||||
Left lateral prefrontal cortex | −40 | 12 | 28 | 9 | 29 | 3.24 | <0.001 |
Within-group genotype t-test (AUD): Val/Val > Val/Met + Met/Met | |||||||
Left lateral prefrontal cortex | −38 | 13 | 28 | 9 | 17 | 3.18 | <0.001 |
Between-group genotype t-test (Val/Val): HC > AUD | |||||||
Left lateral prefrontal cortex | −20 | 23 | −30 | 11 | 332 | 3.88 | <0.001 |
Within-group CTQ t-test ( Val/Met + Met/Met ): low > high CTQ | |||||||
Middle Occipital gyrus | −17 | −93 | 14 | 18 | 708 | 4.78 | <0.001 |
Within-group CTQ t-test (Val/Val): low > high CTQ | |||||||
Middle frontal gyrus | −27 | 25 | −18 | NA | 708 | 4.06 | <0.001 |