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Table 3 Frequency of prescribed drugs in the bipolar sample

From: Predominant polarity in bipolar disorder and validation of the polarity index in a German sample

  N total = 336 DPP MPP UPP Chi Square p adj 1
(100%) N = 169 N = 46 N = 121
(50%) (14%) (36%)
Mood Stabilizers       
  Lithium 165 (49.1) 74 (43.8) 30 (65.2) 61 (50.4) 6.77 .034
  Carbamazepine 10 (3.0) 2 (1.2) 4 (8.7) 4 (3.3) 7.14 .028
  Lamotrigine 32 (9.5) 22 (13.0) 3 (6.5) 7 (5.8) 4.84 .089
  Valproate 100 (29.8) 38 (22.5) 19 (41.3) 43 (35.5) 9.14 .010
  Topiramate 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) - -
FGA 52 (15.5) 16 (9.5) 15 (32.6) 21 (17.4) 15.31 <.000*
SGA 226 (67.3) 109 (64.5) 33 (71.7) 84 (69.4) 1.26 .532
  Quetiapine 138 (41.1) 70 (41.4) 21 (45.7) 47 (38.8) .66 .721
  Aripiprazole 38 (11.3) 22 (13.0) 2 (4.3) 14 (11.6) 2.72 .256
  Clozapine 18 (5.4) 5 (3.0) 4 (8.7) 9 (7.4) 3.96 .138
  Risperidone 40 (11.9) 13 (7.7) 7 (15.2) 20 (16.5) 5.81 .055
  Olanzapine 21 (6.3) 14 (8.3) 2 (4.3) 5 (4.1) 2.40 .301
  Ziprasidone 1 (0.3) 1 (0.6) 0 (0.0) 0 (0.0) 0.99 .609
Pregabalin 17 (5.1) 8 (4.7) 1 (2.2) 8 (6.6) 1.44 .486
Antidepressants 198 (58.9) 121 (71.6) 14 (30.4) 63 (52.1) 28.99 <.000*
  TCAs 91 (27.1) 56 (33.1) 5 (10.9) 30 (24.8) 9.58 .008
  IMAOs 3 (0.9) 3 (1.8) 0 (0.0) 0 (0.0) 2.99 .224
  SSRIs 32 (9.5) 17 (10.1) 2 (4.3) 13 (10.7) 1.70 .428
  SNRIs 75 (22.3) 49 (29.0) 3 (6.5) 23 (19.0) 11.73 .003
  Other 11 (3.3) 6 (3.6) 1 (2.2) 4 (3.3) 0.217 .897
Polypharmacy (total) 170 (50.6) 94 (55.6) 23 (50) 53 (43.8) 3.94 .139
Lithium + other MS 46 (13.7%) 17 (10.1%) 16 (34.8%) 13 (10.8%) 19.98 <.000*
Lithium + SGAs 119 (35.5%) 48 (28.4%) 28 (60.9%) 43 (35.8%) 16.64 <.000*
  1. *p< .05.
  2. DPP = depressive predominant polarity, MPP = manic predominant polarity, UPP = undetermined predominant polarity.
  3. MS = Mood Stabilizer, FGA = first generation antipsychotics, SGA = second generation antipsychotics, MAOs = Monoamine Oxidase Inhibitor.
  4. 1We used bonferroni correction for multiple testing (20 hypotheses) for adjusting the p-values to 0.0025 (0.05/20).