Skip to main content

Table 1 Naranjo score for clozapine-induced pain

From: Burning pain secondary to clozapine use: a case report

Question

Answer

Score

1. Are there previous conclusive reports on this reaction?

No

0

2. Did the adverse event occur after the suspected drug was administered?

Yes

2

3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?

Yes

1

4. Did the adverse reaction reappear when the drug was readministered?

Yes

2

5. Are there alternative causes (other than the drug) that could have on their own caused the reaction?

Don’t know

0

6. Did the reaction reappear when a placebo was given?

Don’t know

0

7. Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?

No

0

8. Was the reaction more severe when the dose was increased or less severe when the dose was decreased?

Yes

1

9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?

Yes

1

10. Was the adverse event confirmed by any objective evidence?

No

0

Total

 

7