Figure 1From: GluN2B protein deficits in the left, but not the right, hippocampus in schizophrenia GluN2B protein and binding density in the hippocampus (dentate gyrus) of schizophrenia and control subjects. a. GluN2B protein density, normalised to β-actin, in the left and right hemisphere of schizophrenia (SZ) and control (CT) subjects. GluN2B was reduced in the left hemisphere of subjects with schizophrenia, compared to the left hemisphere of controls (−43%, p = 0.012) and compared to the right hemisphere of schizophrenia subjects (−40%, p = 0.023 ). *:p < 0.05. b. Representative blot showing GluN2B and β-actin protein expression in control (CT) and schizophrenia subjects (SZ) from the left and right hemisphere. GluN2B was identified as a single band at the expected molecular weight (175 kDa). c. [3H] Ifenprodil binding to GluN2B revealed no significant differences between schizophrenia (SZ) and control (CT) subjects, in the left or right hemisphere. Bars represent mean + SEM.Back to article page