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Table 2 Adjuvant interventions - added to clozapine

From: Treatment resistant schizophrenia: a comprehensive survey of randomised controlled trials

Name of intervention Number Cochrane review
Studies Participants
Antipsychotics  
  Amisulpride 4 322 [21]
  Aripiprazole 5 349  
  Fluphenazine 1 60  
  Haloperidol 2 116  
  Paliperidone 1 70  
  Pipotiazine 1 84  
  Quetiapine 2 136 [21]
  Risperidone 10 646 [21]
  Sertindole 1 50  
  Sulpride 2 150 [21,22]
  Ziprasidone 3 150 [21]
  Clozapine added to 'other antipsychotics' 2 100  
Antidepressants  
  Duloxetine 1 33  
  Fluvoxamine 1 68  
Anticonvulsants/mood stabilisers  
  Valproate 1 34 [23]*
  Lamotrigine 2 85 [24]*
  Lithium 3 152 [25]*
Antimicrobials  
  Inosine 1 66  
Herbal  
  Ginkgo Biloba 1 42  
Anti-diabetic  
Metformin 1 61  
Selective norepinephrine reuptake inhibitor  
  Atomoxetine 1 126  
Drugs Used in Dementia  
  Mematine 1 21 [26]**
Amino acids  
  Glycine 2 31 [27]*
  1. *Review includes interventions that weren't just added to clozapine.
  2. **Protocol and intervention wasn't specifically added to clozapine.