The relationship between glucocorticoid receptor polymorphisms, stressful life events, social support, and post-traumatic stress disorder

Table 5 Interaction effect of the glucocorticoid receptor gene, number of traumatic events, stressful life events, and social support for risk of PTSD when adjusted for age

Variables	Total			With childhood trauma			Without childhood trauma
Variables	n	PTSD %	OR (95% CI)	n	PTSD %	OR (95% CI)	n	PTSD %	OR (95% CI)
A-C-ML-LT-MS	778	14.7	1.00	161	20.5	1.00	617	13.1	1.00
G-G-HL-HT-LS	418	35.9	3.26(2.46,4.32)^a	130	46.2	3.33(1.99,5.57)^a	288	33.7	3.26(2.32,4.57)^a
A-C-HL-HT-LS	948	33.5	2.94(2.31,3.73)^a	227	38.2	2.40(1.49,3.85)^a	721	30.4	2.89(2.18,3.83)^a
A-G-HL-LT-MS	474	29.5	2.44(1.84,3.25)^a	52	36.5	2.23(1.13.4.42)^a	422	30.3	2.88(2.11,3.94)^a
G-G-ML-LT-LS	330	30.9	2.61(1.92,3.55)^a	29	41.4	2.74(1.19,6.29)^a	301	29.2	2.73(1.94,3.85)^a
All Others^a	288	33.3	2.91(2.12,3.99)^a	57	44.6	3.13(1.63,5.98)^a	231	30.6	2.92(2.03,4.20)^a

ML moderate level stressful life events, HL high level stressful life events, HT high number of traumatic events (more than five traumatic events), LT low number of traumatic events (five or fewer events), MS moderate social support or high social support, LS low social support.
^aP<0.05.

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