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Table 5 Association between APOE polymorphisms and MMSE ≤25

From: Influence of multiple APOE genetic variants on cognitive function in a cohort of older men – results from the Normative Aging Study

  

Unadjusted

Fully adjusted*

 

Analysis

OR

(95% CI)

p

OR

(95% CI)

p

rs449647

a

0.431

(0.128 - 1.449)

0.174

0.420

(0.121 - 1.462)

0.424

b

1.190

(0.846 - 1.673)

0.317

1.166

(0.815 - 1.669)

0.401

rs405509

a

1.201

(0.819 - 1.762)

0.349

1.237

(0.824 - 1.857)

0.304

b

0.994

(0.689 - 1.435)

0.975

0.955

(0.649 - 1.406)

0.817

rs440446

a

1.360

(0.873 - 2.120)

0.174

1.305

(0.813 - 2.094)

0.271

b

1.024

(0.732 - 1.434)

0.889

0.997

(0.700 - 1.421)

0.989

rs429358

a

0.498

(0.112 - 2.212)

0.359

0.591

(0.125 - 2.799)

0.507

b

0.634

(0.422 - 0.954)

0.029

0.620

(0.405 - 0.950)

0.028

rs7412

a

N/A

  

N/A

  

b

0.732

(0.442 - 1.211)

0.225

0.697

(0.411 - 1.182)

0.180

  1. N/A: Low number of individuals.
  2. OR = Odds Ratio; 95%CI = 95% Confidence Interval.
  3. *Adjusted for race, education, alcohol consumption, physical activity, diabetes mellitus, fish consumption, computer experience, English as a first language, cholesterol, smoking, obesity, and hypertension.
  4. Analysis a = (Wildtype + Heterozygous) vs. Polymorphic Homozygous genotypes. Analysis b = Wildtype vs. (Heterozygous + Polymorphic Homozygous) genotypes. Bold highlights statistical significant result.