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Table 2 Distribution of HADS-score related to genotype of COMT in men and women.

From: Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT)

  Met/Met Val/Met Val/Val
  No. % No. % No. %
Genotypes       
Men       
Controls (HADS-D< 8 + HADS-A < 8) 579 33.9 829 48.5 301 17.6
HADS-D ≥ 8 71 30.2 122 51.9 42 17.9
HADS-D ≥ 111 13 18.3 40 56.3 18 25.4
HADS-A ≥ 8 70 29.7 123 52.1 43 18.2
HADS-A ≥ 11 16 25.0 39 60.9 9 14.1
Combined (HADS-D ≥ 8+HADS-A ≥ 8) 30 30.9 53 54.6 14 14.4
Unclassified (incomplete data) 29 29.5 226 51.6 83 18.9
Women       
Controls (HADS-D< 8 + HADS-A < 8) 549 30.6 889 49.5 358 19.9
HADS-D ≥ 8 96 35.2 132 48.4 45 16.5
HADS-D ≥ 111 27 32.9 37 45.1 18 22.0
HADS-A ≥ 8 125 34.2 175 47.8 66 18.0
HADS-A ≥ 11 46 37.4 53 43.1 24 19.5
Combined (HADS-D ≥ 8+HADS-A ≥ 8) 47 37.3 55 43.7 24 19.0
Unclassified (incomplete data) 227 32.4 338 48.2 136 19.4
Alleles Met Val   
Men       
Controls 1987 58.1 1431 41.9   
HADS-D ≥ 8 264 56.2 206 43.8   
HADS-D ≥ 112 66 46.5 76 53.5   
HADS-A ≥ 8 263 55.7 209 44.3   
HADS-A ≥ 11 71 55.5 57 44.5   
Combined (HADS-D ≥ 8+HADS-A ≥ 8) 113 58.2 81 41.8   
Unclassified (incomplete data) 484 55.3 392 44.7   
Women       
Controls 1987 55.3 1605 44.7   
HADS-D ≥ 8 324 59.3 222 40.7   
HADS-D ≥ 112 91 55.5 73 44.5   
HADS-A ≥ 8 425 58.1 307 41.9   
HADS-A ≥ 11 145 58.9 101 41.1   
Combined (HADS-D ≥ 8+HADS-A ≥ 8) 49 59.1 103 40.9   
Unclassified (incomplete data) 792 56.5 610 43.5   
  1. 1. Male cases with HADS-D ≥ 11 versus male controls: p = 0.01.
  2. 2. Male cases with HADS-D ≥ 11 versus male controls: p = 0.006