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Table 1 COMT genotypes related to sex, mean age, education > 12 years, mean systolic and diastolic blood pressure, and several factors associated with hypertension.

From: Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT)

 

No COMT genotyping

Met/Met

Val/Met

Val/Val

Characteristics

(n = 60,072)

(n = 1769)

(n = 2726)

(n = 1036)

Sex, female (%)

53.1

53.7

54.3

56.1

Age, mean (SD)

49.2 (17.3)1

50.7 (17.9)

50.7 (18.0)

50.2 (17.7)

Education > 12 years (%)

19

18

18

18

Median systolic blood pressure (mmHg)

1341

136.5

136

136

Median diastolic blood pressure (mmHg)

791

80

80

80

Body mass index, kg/m2 (SD)

26.4 (4.1)

26.4 (4.1)

26.3 (4.1)

26.3 (4.2)

Cholesterol, mmol (SD)

5.89 (1.26)1

5.96 (1.30)

5.96 (1.30)

6.02 (1.33)

Current smoking (%)

28.2

27.9

28.4

29.6

High level of physical activity (%)

15.81

13.9

14.1

14.8

Diabetes mellitus (%)

3.21

1.3

1.3

1.1

Myocardial infarction (%)

3.3

3.8

3.4

2.32

Angina pectoris (%)

5.01

6.7

5.8

5.1

Stroke (%)

1.9

2.1

1.8

1.8

Headache (%)

38.6

39.7

40.0

37.9

Chronic musculoskeletal pain (%)

46.31

46.4

50.5

48.6

  1. 1. Genotyped versus not genotyped: p < 0.003.
  2. 2. Val/Val versus other genotypes: p = 0.046.
  3. Heart disease (myocardial infarction and/or angina pectoris):
  4. Val/Val versus other genotypes: p = 0.02 Genotyped versus not genotyped: p < 0.02