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Figure 1 | BMC Psychiatry

Figure 1

From: Evaluating dose response from flexible dose clinical trials

Figure 1

Marginal structural model with IPTW. A. Cumulative potential dose effect profiles by dose groups for Study A (each dose profile is estimated from MSM model for a hypothetical patient of average baseline severity who would have continuously received the same dose throughout the study); estimated from marginal structural model with IPTW for reduction in the Young Mania Rating Scale (YMRS) total score in patients with bipolar disorder. Olanzapine (Olz): For 20 vs. 5–10 mg, overall dose effect NS; significant negative dose effect (p < .05) at Weeks 4, 7, 8, 10. B. Cumulative potential dose effect profiles by dose groups for Study B (each dose profile is estimated from MSM model for a hypothetical patient of average baseline severity who would have continuously received the same dose throughout the study); estimated by marginal structural model with IPTW for reduction in the Positive and Negative Syndrome Scale (PANSS) total score in patients with schizophrenia. Olanzapine (Olz): no significant overall dose effect; significant negative dose effect (p < .05) at Weeks 20, 24.

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