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Table 2 Total days on index drugs and concomitant antipsychotics.

From: Cost of antipsychotic polypharmacy in the treatment of schizophrenia

Concurrent drug class with index drug OLZ
(N = 405)
RIS
(N = 276)
QUE
(N = 115)
p-value**
(OLZ vs QUE)
p-value**
(OLZ vs RIS)
p-value**
(RIS vs QUE)
Total days on index drug post 1 year after initiation 280 260 239 0.0028 0.0435 0.0557
First episode of continuously on index drug 272 250 225 0.0023 0.0908 0.0162
Total concurrent days on other antipsychotics*       
   on other atypicals 36.1 49.4 110.6 < 0.0001 0.0742 0.0001
   on typicals 105.1 79.3 69.4 0.0107 0.0119 0.4723
   on all anti-psychotics 136.6 120.3 160.2 0.1106 0.1378 0.0109
Percent of patients with >= 30 days of concurrent use       
   on other atypicals 18.5% 25.4% 52.2% < 0.0001 0.0322 < 0.0001
   on typicals 48.2% 38.4% 33.0% 0.0041 0.0120 0.3171
   on all anti-psychotics 61.7% 55.1% 72.2% 0.0396 0.0831 0.0017
  1. * Total concurrent days of other antipsychotics while on the first episode of the index drug.
  2. ** Adjusted with comorbidity, age, race, gender, hospitalization status at initiation, schizoaffective diagnosis and insurance, site, time to initiation.