From: No association between the PREP gene and lithium responsive bipolar disorder
Each patient must meet criteria A, B and C | |
A. | Diagnosis of primary episodic bipolar disorder based on the SADS-L (lifetime version) interview and Research Diagnostic Criteria (RDC). |
B. | High Recurrence Risk |
either | B1: five or more episodes prior to lithium treatment |
or | B2: four episodes prior to lithium; of these two or more during the 2 years preceding lithium treatment |
or | B3: three episodes prior to lithium, plus one more within 12 months after lithium discontinuation |
C. | Unequivocal Lithium Response |
C1: No recurrence requiring additional biological intervention (ECT, antidepressants, neuroleptics) during the entire observation time on lithium monotherapy | |
and | C2: minimum period of observation of 3 years |
and | C3: average plasma lithium concentration over 0.6 mEq L-1 |