Table 3 Cardiac Parameters and Baseline and Endpoint
Placebo N = 116 | IR-MPH (tid) N = 102 | OROS-MPH N = 67 | ||
|---|---|---|---|---|
mean ± sd | mean ± sd | mean ± sd | Omnibus Statistic | |
Systolic Blood Pressure | ||||
Baseline | 121.4 ± 13.7 | 125.6 ± 13.3 | 119.2 ± 13.2 | |
Endpoint | 120.3 ± 13.0 | 127.5 ± 12.7 | 122.6 ± 11.9 | |
Change | -1.2 ± 12.3 | 2.0 ± 12.6 | 3.5 ± 11.8 | χ2 (2) = 6.7, p = 0.03 |
Diastolic Blood Pressure | ||||
Baseline | 71.3 ± 10.5 | 75.1 ± 9.6 | 68.6 ± 8.9 | |
Endpoint | 69.8 ± 10.0 | 77.3 ± 9.2 | 72.8 ± 9.3 | |
Change | -1.5 ± 8.4 | 2.1 ± 8.8 * | 4.0 ± 8.5 * | χ2 (2) = 19.9, p < 0.0001 |
Pulse | ||||
Baseline | 76.2 ± 10.9 | 76.5 ± 12.5 | 78.2 ± 11.6 | |
Endpoint | 71.5 ± 10.9 | 82.3 ± 12.7 | 82.9 ± 12.6 | |
Change | -4.8 ± 11.7 | 5.9 ± 12.9* | 4.5 ± 10.5*,$ | χ2 (2) = 27.9, p < 0.0001 |
PR Interval | ||||
Baseline | 153.2 ± 18.7 | 151.3 ± 25.8 | 151.3 ± 18.3 | |
Endpoint | 151.8 ± 17.8 | 147.9 ± 20.4 | 147.9 ± 21.1 | |
Change | -1.1 ± 13.7 | -2.5 ± 11.8 | -1.2 ± 11.3 | χ2 (2) = 0.6, p = 0.8 |
QRS Interval | ||||
Baseline | 87.5 ± 10.9 | 90.1 ± 12.8 | 93.3 ± 9.9 | |
Endpoint | 88.1 ± 10.4 | 87.8 ± 10.9 | 91.5 ± 11.3 | |
Change | 0.5 ± 8.6 | -1.2 ± 9.7 | -1.2 ± 5.8 | χ2 (2) = 3.1, p = 0.2 |
QTc Interval@ | ||||
Baseline | 413.4 ± 18.0 | 417.1 ± 19.8 | 412.5 ± 15.6 | |
Endpoint | 413.6 ± 16.3 | 420.9 ± 18.4 | 414.5 ± 18.8 | |
Change | 0.5 ± 18.4 | 6.1 ± 16.0 | 1.9 ± 15.7 | χ2 (2) = 2.7, p = 0.3 |