Duloxetine in the treatment of major depressive disorder: an open-label study

BMC Psychiatry

Table 4 Summary of efficacy measures

	Baseline, mean (SD)	Endpoint, mean (SD)	p-value^a
Hamilton Rating Scale for Depression total score (n = 511)	23.7 (3.6)	9.9 (7.7)	T = -39.1, df = 510, p < .001
Hamilton Rating Scale for Depression subscales (n = 511)
Core	9.5 (1.7)	3.4 (3.7)	T = -37.2, df = 510, p < .001
Maier	12.2 (2.0)	4.5 (4.4)	T = -38.1, df = 510, p < .001
Anxiety/Somatization	7.6 (1.9)	3.6 (2.7)	T = -30.7, df = 510, p < .001
Retardation	8.2 (1.5)	3.4 (3.1)	T = -35.3, df = 510, p < .001
Sleep	3.8 (1.7)	1.7 (1.8)	T = -23.5, df = 510, p < .001
Clinical Global Impression of Severity (n = 512)	4.6 (0.6)	2.3 (1.3)	T = -36.1, df = 511, p < .001
Patient Global Impression of Improvement (n = 511)	N/A	2.6 (1.4)	N/A

LOCF mean change analysis
^a p-values are from paired t-test for mean change from baseline to endpoint = 0.

ISSN: 1471-244X