Skip to main content

Table 2 Outcomes by gender and treatment group

From: Acute weight gain, gender, and therapeutic response to antipsychotics in the treatment of patients with schizophrenia

 

Women

Men

 

Olanzapine

Haloperidol

Olanzapine

Haloperidol

Outcome measure

Baseline

Endpoint

Baseline

Endpoint

Baseline

Endpoint

Baseline

Endpoint

Core symptoms

        

   BPRS positive

10.1 (4.0)

6.5 (4.8)

9.9 (4.3)

6.9 (4.4)

10.3 (4.1)

7.0 (4.6)

10.7 (4.0)

8.0 (4.6)

   BPRS negative*

6.6 (3.3)

4.4 (3.1)

6.8 (3.4)

5.5 (3.3)

6.7 (3.2)

4.8 (2.9)

6.8 (3.5)

5.5 (3.2)

Depressive symptoms

        

   MADRS*

17.8 (9.6)

11.0 (9.3)

16.1 (8.6)

13.5 (10.7)

16.0 (8.4)

10.5 (7.7)

17.0 (8.7)

13.7 (9.4)

   BPRS anxiety & depression*

8.1 (3.8)

5.0 (4.0)

7.8 (4.1)

6.0 (4.3)

7.1 (3.7)

4.5 (3.6)

7.7 (3.9)

5.7 (3.9)

Functioning

        

   SF-36 mental component*

34.7 (13.1)

41.8 (12.1)

34.2 (12.4)

36.5 (13.0)

34.6 (12.4)

40.6 (12.0)

34.7 (11.7)

37.8 (12.3)

   SF-36 physical component*

41.3 (14.3)

45.0 (13.9)

41.9 (13.5)

42.1 (13.8)

44.7 (12.2)

48.7 (11.6)

43.9 (13.2)

45.4 (13.1)

Weight

        

   Weight, kg* †

68.9 (15.5)

70.5 (15.8)

72.6 (17.8)

72.4 (17.6)

80.3 (15.9)

82.5 (16.2)

80.7 (17.1)

81.0 (17.4)

   BMI* †

26.1 (5.4)

26.7 (5.5)

27.2 (6.6)

27.1 (6.5)

25.8 (4.8)

26.5 (4.9)

25.7 (5.0)

25.8 (5.0)

  1. * Therapy effect (p < .05), reflecting significant differences between olanzapine and haloperidol-treated patients at baseline.
  2. † Gender effect (p < .05), reflecting significant differences between women and men on weight parameters within each treatment group at baseline, and between women and men when combined baseline values across treatment groups.