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Table 2 Daily Dose (mg/day) of Index Atypical Antipsychotic: During the 1-Year Post Initiation, at Initiation, and at Endpoint

From: Antipsychotic monotherapy and polypharmacy in the naturalistic treatment of schizophrenia with atypical antipsychotics

Group/Time Mean (SD) Median Min/Max Mean Mono/Poly*
Olanzapine     
   1-Year 13.9 (7.4) 10.0 2.5/40 15.1/13.5
   Initiation 10.0 (6.1) 10.0 2.5 / 40 10.7 / 9.5
   Endpoint 14.2 (8.4) 10.0 2.5 / 50 13.9 / 14.5
Quetiapine     
   1-Year 330 (214) 295 25/850 305/334
   Initiation 164.2 (151) 100 12.5 / 800 223 / 138
   Endpoint 341 (277) 300 25 / 1300 369 / 330
Risperidone     
   1-Year 4.2 (2.3) 3.9 0.28/12.9 4.7/3.9
   Initiation 2.7 (2.0) 2.0 0.25 / 12 3.2 / 2.4
   Endpoint 4.3 (2.7) 4.0 0.25 / 16 4.5 / 4.1
  1. * Mean Mono/Poly indicates the mean dose (mg/day) for patients while on antipsychotic monotherapy, and while on antipsychotic polypharmacy