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Table 6 Mean changes from baseline to week 9 in melancholic patients (focus studies)

From: Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in patients with and without melancholic features

 

Mean Change (SE)

p-value

 

Duloxetine 60 mg QD (n = 153)

Placebo (n = 163)

 

HAMD 17 Total Score

-11.02 (0.65)

-7.51 (0.61)

<.001

Subscales

   

   Maier

-6.16 (0.36)

-3.95 (0.34)

<.001

   Anxiety

-2.65 (0.22)

-2.29 (0.21)

.230

   Retardation

-4.52 (0.26)

-2.67 (0.24)

<.001

   Sleep

-1.78 (0.17)

-1.17 (0.16)

.007

VAS Overall Pain a

-6.12 (-22.8)

0.13 (0.48)

.002

CGI-Severity

-1.84 (0.11)

-1.30 (0.10)

<.001

PGI-Improvement b

2.47 (0.11)

3.08 (0.11)

<.001

  1. CGI = Clinical Global Impression; HAMD = Hamilton Rating Scale for Depression; PGI = Patient Global Impression
  2. a. Values are mean change (percentage mean change), and p value is from main effect of treatment
  3. b. Mean score (SE). Lower mean score indicates greater improvement.
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BMC Psychiatry

ISSN: 1471-244X

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