Skip to main content

Table 1 Serotonin receptor 5-HT2C (HTR2C) genotypes and relationships to monoamine metabolite concentrations in human lumbar cerebrospinal fluid.

From: Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers

   

5-HIAA

HVA

MHPG

HTR2C Allele/genotype

Sex

n

Mean ± SD (nmol/L)

Fa pa

Fb pb

Mean ± SD (nmol/L)

Fa pa

Fb pb

Mean ± SD (nmol/L)

Fa pa

Fb pb

Cys23

Men

43

92 ± 40

F = 0.27

F = 0.13

166 ± 75

F = 0.73

F = 0.50

43 ± 8

F = 1.75

F = 1.48

Ser23

 

6

86 ± 16

p = 0.61

p = 0.72

144 ± 39

p = 0.40

p = 0.48

39 ± 4

p = 0.19

p = 0.23

Cys23Cys

Women

30

105 ± 39

F = 0.66

F = 0.57

194 ± 77

F = 2.14

F = 1.34

40 ± 6

F = 1.03

F = 0.91

Cys23Serc

 

6

118 ± 29

p = 0.42

p = 0.46d

231 ± 69

p = 0.15

p = 0.25e

44 ± 8

p = 0.32

p = 0.35f

Ser23Serc

 

1

107

  

229

  

38

  
  1. 5-HIAA = 5-hydroxyindoleacetic acid; HVA = homovanillic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol. Statistical comparisons done on monoamine metabolite residuals correcteda and uncorrectedb for back length. c Cys23Ser and Ser23Ser genotypes were combined in the analyses. d Correction for use of oral contraceptives, F = 0.21, p = 0.65. e Correction for use of oral contraceptives, F = 0.84, p = 0.37. f Correction for use of oral contraceptives, F = 0.22, p = 0.64.