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Enhanced physical health screening for people with severe mental illness in Hong Kong: results from a one-year prospective case series study
© Bressington et al.; licensee BioMed Central Ltd. 2014
Received: 29 July 2013
Accepted: 17 February 2014
Published: 27 February 2014
People with severe mental illness have significantly poorer physical health compared to the general population; previous health screening studies conducted outside Asian countries have demonstrated the potential in addressing this issue. This case series aimed to explore the effects and utility of integrating an enhanced physical health screening programme for community dwelling patients with severe mental illness into routine clinical practice in Hong Kong.
This study utilises a consecutive prospective case series design. The serious mental illness Health Improvement Profile (HIP) was used as a screening tool at baseline and repeated at 12 months follow-up.
A total of 148 community-based patients with severe mental illness completed the study. At one year follow-up analysis showed a significant improvement in self-reported levels of exercise and a reduction in the numbers of patients prescribed medications for diabetes However, mean waist circumference increased at follow-up. In addition to the statistically significant results some general trends were observed, including: a lack of deterioration in most areas of cardiovascular risk; a reduction in medicines prescribed for physical health problems; and general improvements in health behaviours over the 12 month period.
The findings demonstrate that using the HIP is feasible and acceptable in Hong Kong. The results of the enhanced physical health-screening programme are promising, but require further testing using a randomised controlled trial design in order to more confidently attribute the improvements in well-being and health behaviours to the HIP.
Clinical trial registration number: ISRCTN12582470
The poor physical health state of people with severe mental illness (SMI) is well established ; people with SMI are at significantly increased risk from a variety of long term physical health problems in comparison to the general population. The increased morbidity of physical health conditions such as cardiovascular disease, obesity, diabetes, metabolic syndrome and hypertension have led to high mortality rates in people with SMI; in schizophrenia, standardised mortality ratios are increased up to four-fold compared with the general population [2–5]. It is estimated that people with SMI have a life-span of between 10 and 30 years less than the general population; which has been observed to be deteriorating over the last decade .
In response to the physical health inequalities observed in people with SMI many health care providers in a variety of different countries have produced policies and clinical guidelines which recommend regular physical health screening in this patient group [4, 7–9]. The increased focus on the physical health of people with SMI has also resulted in some countries using financial incentives to improve the regularity of screening; for example, in the UK general medical practitioners in primary care settings are offered additional payment for recording the health status of people with SMI .
Service improvement and implementation studies have demonstrated that clinicians in mental health services are able to successfully conduct enhanced physical health screening when they are provided with sufficient guidance, training and resources; for example Mangurian et al.,  reported that 50% of 15,000 outpatients in New York State were able to have Body Mass Index, blood pressure and smoking status recorded over just a four month period. Similarly in the UK; Barnes et al.,  reported that a quality improvement programme effectively increased levels of screening for metabolic syndrome in community psychiatric patients prescribed antipsychotics. An earlier study conducted in the US  reinforces the potential benefits of screening as the results demonstrated that structured health monitoring was effective in detecting physical health problems in people with mental illness.
Once physical health co-morbidities have been identified, interventions to address the problems need to be tailored for patients based on their individual circumstances. Reasons for the poor physical health state of individuals with SMI are multi-factorial; but are likely to relate to a combination of lifestyle issues, diagnostic over-shadowing, adverse effects of prescribed medication, difficulty detecting physical health concerns, patient reluctance to report health problems and the potential impact of psychiatric symptoms on health behaviours [6, 14]. A recently published systematic review of the physical health intervention literature  concluded that mental health nurses were well-placed to address health behaviours in mental health patients and that specific interventions can result in significant improvements in both health behaviours and physical health outcomes. Although there is currently a lack of evidence from randomised controlled trials  the results from less methodologically robust studies suggest that “well-being” initiatives may result in improved patient outcomes [17, 18].
Given the close relationship between lifestyle and health, some studies have investigated the use of enhanced screening procedures which combine the identification of both physical co-morbidity and the health behaviours of patients in order to target clinical interventions. With this intention, White et al.,  developed the serious mental illness Health Improvement Profile (HIP) screening tool and through a pilot study demonstrated the face validity and acceptability of the HIP to both clinicians and patients. The HIP is intended to be used by mental health nurses as a pragmatic physical health risk assessment which aims to direct individualised clinical interventions based on the patient’s physical health state and their responses to the questions about health behaviours. The HIP consists of 27 items which are flagged as “red” for unhealthy (indicating that intervention is required) or “green” for healthy (where no intervention is required).
Subsequently, a pilot study which aimed to establish the clinical utility of the HIP was conducted by Shuel et al.,  in the UK. The tool was completed with 31 community mental health patients and the results showed that mental health nurses effectively detected physical comorbidity and were also able to use the findings to plan and recommend tailored evidence-based interventions. The study’s qualitative data further demonstrated that using the HIP was acceptable to patients and their clinicians.
The previous physical health screening studies are primarily confined to English speaking countries and as there have been no similar studies to date that have been carried out in Asian populations the transferability of the intervention beyond western cultures has yet to be ascertained. Therefore, this prospective case series aims to demonstrate proof of concept by exploring the use of a health improvement screening tool (HIP)  in Hong Kong. The authors of the HIP state that the measure should be used as a tool for eliciting positive change , and therefore this study also aims to seek to establish the potential effects of utilising the HIP by repeating the measure at 12 months follow-up.
To explore the utility and potential impact of the HIP screening tool in routine clinical practice on the physical health state and health behaviours of people with SMI after 12 months.
The study utilises a prospective case series study design. The HIP was used as a screening tool at baseline and repeated at 12 months follow-up. In addition to gathering longitudinal data about physical state and health behaviours over one year, the findings were used to inform potential individualised interventions. The following demographic and clinical characteristics were also recorded: age, gender, education, marital status, diagnosis, duration of illness, employment status and prescribed medication.
Recruitment and selection
The 30 Community Psychiatric Nurses (CPNs) who participated in the study were trained in how to use the HIP and how to conduct the required physical examinations. Each CPN aimed to recruit 5 patients who met the inclusion criteria and complete the HIP with them at baseline and at 12 months follow-up. In line with a consecutive recruitment strategy; CPNs sought informed consent from the patients who they were scheduled to see for routine appointments until a minimum of at least 5 patients agreed for their data to be used.
Male or female. Aged from 18–65 years; (2) with a diagnosis of SMI defined by a case-note diagnosis of schizophrenia, schizoaffective disorder, psychotic depression or bipolar affective disorder (type 1 or 2).
Any service user who did not have capacity to provide informed consent was excluded from the study.
Ethical approval was obtained from the Hong Kong New Territories West Cluster Clinical and Research Ethics Committee prior to commencement of the project. Participants who met the inclusion criteria were required to provide written informed consent in order to participate; the participant information sheets reiterated that taking part was entirely voluntary and those patients who declined to take part would not have their clinical treatment negatively influenced.
1. Body mass index
15. Breast check (female and male)
2. Waist circumference
16. Menstrual cycle (female)
17. Smoking status
4. Blood pressure
19. Alcohol intake
6. Liver function tests
20. Diet: 5-a-day
7. Lipid levels
21. Diet: fat intake
22. Fluid intake
9. Cervical smear (women only)
23. Caffeine intake
10. Prostate and testicles check (men only)
24. Cannabis use
25. Safe sex
28. Sex satisfaction
The parameters for use in Hong Kong required modification in relation to waist circumference and Body Mass Index (BMI) to ensure that they reflected the values recommended for an Asian population. As there has been some debate in the literature about the most relevant BMI cut off points for being defined as overweight in Hong Kong , for clarity we present the results of numbers of patients with a BMI of ≥23 kg/m2 (the usual cut-off value for being determined as overweight in a Chinese population) and ≥25 kg/m2 (the usual cut-off value for being overweight in a European population).
The biometric data (blood tests etc.) required to complete the HIP were obtained from the most recent outpatient records and patients were therefore not required to undergo any investigations that would not normally be considered as part of routine clinical practice. CPNs collected data to ensure that they would be immediately aware of physical health problems that were detected and also be able to recommend health behaviour interventions or refer patients to the appropriate existing clinical service based on the findings from the HIP.
Data analysis strategy
Data were entered into SPSS version 21. Descriptive statistical analysis was undertaken to establish means/standard deviations and frequencies at baseline and follow-up. Paired samples T-tests were conducted to explore significant differences in the pre and post means of continuous variables, whilst Chi-square or McNemar tests were conducted to determine differences in the categorical variables at baseline and follow-up. Further analysis of variance and binomial logistic regression were conducted to explore the origins of observed change in selected variables.
Demographic and clinical characteristics of study participants
Demographic and clinical characteristics of participants
Bipolar affective disorder (BPAD)
Other (i.e. schizoaffective disorder; non-specified psychosis)
Prescribed medications at baseline and follow-up
Prescribed Medication at baseline and follow-up
Baseline - number (%)
Follow-up - number (%)
Number of antipsychotics prescribed
P = 0.71
Prescribed first generation antipsychotics
P = 0.17
Prescribed second generation antipsychotics
P = 0.73
P = 1.00
Prescribed long acting antipsychotic injection
P = 1.00
Prescribed an antihypertensive
P = 0.07
Prescribed a statin
P = 1.00
Prescribed diabetes treatment
P = 0.04*
The numbers of patients prescribed medications for physical health problems slightly reduced at follow-up; however, McNemar tests reveal that the only statistically significant reduction was in the numbers of people being prescribed treatment for diabetes (p = 0.04). Very few patients were receiving medications for hypercholesterolemia at both time points, whilst prescriptions for hypertension reduced at follow-up from 21% to 14% of patients.
Cardiovascular risk measurements at baseline and follow-up
Mean and SD of cardiovascular risk measurements at baseline and follow-up
Baseline mean (SD)
Follow-up mean (SD)
BMI (n = 137)
P = 0.55
Weight (n = 129)
P = 0.67
Waist circumference - cm (n = 90)
P = 0.03*
Blood pressure - diastolic (n = 96)
P = 0.40
Blood pressure - systolic (n = 96)
P = 0.18
Total cholesterol - mmol/L (n = 33)
P = 0.24
LDL cholesterol - mmol/L (n = 33)
P = 0.19
Fasting plasma glucose - mmol/L (n = 53)
P = 0.89
Triglycerides (n = 31)
P = 0.99
Flagged indicators of cardiovascular risk at baseline and follow-up
Flagged indicators of cardiovascular risk at baseline and follow-up
Baseline n (%)
Follow-up n (%)
BMI overweight - Hong Kong criterion
P = 0.15
Red flagged (BMI ≥ 23)
Green flagged (BMI = 18.50-22.99)
BMI overweight- international criterion
P = 0.58
Red flagged (BMI ≥ 25)
Green flagged (BMI = 18.50-24.99)
P = 0.07
Red flagged (males ≥ 90 cm, females ≥ 80 cm)
Green flagged (males < 90 cm, females < 80 cm)
P = 1.00
Red flagged (BP ≥ 140/90)
Green flagged (BP < 140/90)
P = 0.38
Red flagged (Total Cholesterol ≥ 6.2 mmol/L)
Green flagged (< 6.2 mmol/L)
Raised LDL cholesterol
P = 0.21
Red flagged (LDL ≥ 4.1 mmol/L)
Green flagged (< 4.1 mmol/L)
Raised fasting plasma glucose
P = 0.21
Red flagged (Glucose - ≥ 7.00 mmol/L)
Green flagged (< 7.0 mmol/L)
P = 1.00
Red flagged (Triglycerides - ≥ 2.2 mmol/L)
Green flagged (< 2.2 mmol/L)
Patient’s health behaviours
Health behaviours of participants at baseline and follow-up
Baseline n (%)
Follow-up n (%)
P = 0.79
Red flagged (≥ 4 units daily)
Green flagged (< 2-3 units/day)
P = 0.45
Red flagged (smoker/passive smoker)
Green flagged (non-smoker/non passive smoker)
P = 0.79
Red flagged (≥ 600 mg/day)
Green flagged (< 600 mg/day)
P = 0.02*
Red flagged (< 30 minutes a day for 5 days per week)
Green flagged (≥ 30 minutes a day for 5 days per week)
Diet fruit and vegetables
P = 0.08
Red flagged (≤ 2 daily portions)
Green flagged (≥ 5 daily portions)
P = 0.74
Red flagged (≥ 2 portions per day)
Green flagged (≤ 1 portion per day)
P = 0.15
Red flagged (>8 h or <3 h)
Green flagged (7 – 8 hours)
In order to further explore the origins of the significant change we observed in waist circumference, we conducted analyses of variance and binomial logistic regression. In the first instance, we used five classifications of BMI values that suggest different levels of obesity (underweight ≤ 18.49 kg/m2, normal weight = 18.50-24.99 kg/m2, overweight = 25-29.99 kg/m2, obese = 30-39.99 kg/m2, morbid obesity ≥ 40 kg/m2) as a between subjects factor to detect mean differences in waist circumference change (computed as the difference between measurements at baseline and follow-up). The ANOVA showed no significant difference between the five BMI categories in terms of waist change F (4,85) = 0.611, p = 0.66. We then then conducted a binomial logistic regression in order to predict levels of waist change (where no changes or decreases in waist circumference measurements between baseline and follow up were recoded as 0 and increases were recoded as 1) from a mixture of categorical (gender, diagnosis, occupation, prescribed medication) and continuous (age, duration of illness) predictors. None of the models calculated (simultaneous or stepwise) resulted in a fitting model able to correctly predict cases much beyond chance.
The physical health state of the patients involved in this study is markedly worse than the general Hong Kong population. Although direct comparisons are complicated by differing settings and age distributions, data reported by Ko et al.,  suggests that 44% of women and 68% of men aged 40–50 years in the Hong Kong working population were overweight (defined as a BMI ≥23) and the current study indicates that at baseline 77% of men and 76% women are overweight. In terms of waist circumference; Ko et al.,  estimate the prevalence of central obesity as 30% for men and 29% for women, whilst our study shows that 42% of women and 61% of men were centrally obese at baseline. Therefore, these results indicate that men are more than twice as likely to have central obesity and women are over 1½ times more likely to be overweight compared to the general population; findings which are supported by a number of other studies conducted in different countries that estimate the relative risk of obesity in people with schizophrenia as being between 1.5 and 2 [6, 23, 24].
This study shows that the challenges mental health practitioners face when promoting physical health in Hong Kong are comparable to those observed in western countries. The prevalence of being overweight in this study is broadly similar to that of SMI patients screened using the HIP in Scotland; Shuel et al.,  reported that 77% of patients were overweight (72% were overweight at follow-up in the present study). Whilst central obesity was slightly less prevalent in this study (61% compared to 70% in Scotland), rates of hypertension were higher (21% verses 13%) and raised plasma glucose levels were also more common (14% compared to 10% in Scotland). Interestingly, with the exception of alcohol use and fruit/vegetable consumption the self-reported health behaviours of the patients in this study are somewhat worse than those reported by Shuel et al., ; most noteworthy is the 64% of patients in Hong Kong who at baseline were not exercising at recommended levels (in comparison with 29% in Scotland).
Our results show that after one year there were some encouraging improvements in relation to both health behaviours and indicators of cardiovascular risk. Although not statistically significant, most areas of cardiovascular risk improved over the course of the study. Disappointingly, despite some slight improvement in BMI, the mean waist circumference measurement of participants significantly increased by 2.58 cm at follow-up (p = 0.03). This result may be confounded by the lack of objective verification that all the waist circumference measurements conducted by clinicians adhered to the suggested protocol. Although the clinicians carrying out measurements were instructed to place the tape measure across the umbilicus, there are at least 6 established alternative waist measurement points that are used routinely in practice, which are equally predictive of cardiovascular risk but which will all produce different results .
In terms of the health behaviours which are modifiable physical health risk factors; all areas showed minor improvements, including a 7% increase in the number of patients eating sufficient fruit and vegetables, but only exercise improved to a statistically significant level (p = 0.02). Therefore, despite some positive outcomes in health behaviours, with the exception of waist circumference the physical state of patients remained largely unchanged over the 12 month period of the study. Our findings are similar to some of the previous exercise and nutritional studies which have shown that although health behaviours improved in patients with SMI, this did not manifest in significant reductions in BMI, waist circumference or body weight, however the interventions may have prevented further deterioration [26–29].
Given the poor physical state of patients at commencement of the study it would be appropriate to assume that physical health would have deteriorated further after 1 year and this could indicate that the enhanced screening using the HIP prevented some further decline. This hypothesis is supported by the observed marked physical health deterioration in treatment as usual (TAU) SMI control groups in some previous studies, for example: Littrell et al.,  report that the mean weight in the TAU group steadily increased over 16 weeks in a psycho-educational study; the TAU group in a healthy living programme showed a 8.1% gain in BMI over one year  and mean waist circumference increased by 1.2 cm over three months in the TAU group in a “solution for wellness” group intervention programme conducted by Porsdal et al., .
Our results highlight that there was little change in the numbers and types of psychotropic medications prescribed over the duration of the study. But there was a significant reduction in the numbers of patients being treated with medications for diabetes; this is a promising finding and could suggest that the improvements in exercise and diet have resulted in better glycaemic control, necessitating a reduced need for medication. However, due to the lack of control group, abundance of extraneous variables and in the absence of objective measures of health behaviour changes, it is not possible to confidently attribute improvements in the need for diabetes treatments to the enhanced screening programme. Despite the methodological shortfalls of the present study, our hypothesis may be supported by many previous research studies which show that people with sedentary lifestyles and poor dietary habits have a substantially increased risk of diabetes [33, 34], and also that exercise and diet interventions can reduce the risk of diabetes more dramatically than the effects of medication .
The study demonstrates that use of the HIP as a screening tool in Hong Kong is both feasible and useful to identify areas where physical health requires intervention. As a potential secondary gain enhanced physical health monitoring may also address concerns about treatment; Bressington et al.,  demonstrated that patients and families in Hong Kong are concerned about the effects of psychotropic medications on patients’ physical health, if there is increased attention in this area perhaps this will go some way to reinforcing that these concerns are being taken seriously and hence provide some reassurance in this regard. The numbers of patients who agreed to participate and completed the study suggest that an increased clinical focus on physical health problems is acceptable from a patient perspective, but in order to maximise the potential of health behaviour interventions clinicians need to ensure that there are adequate services available to provide ongoing support; which will entail a co-ordinated interprofessional intensive effort from health care workers.
Strengths and limitations of the study
We are unable to make assertions from our results about causality due to the prospective case series design of the study. Due to the lack of a control group and absence of objective measures of behaviour it is not possible to confidently ascribe the improvements in health behaviours or lack of deterioration in physical health to the HIP screening programme; the changes in physical state may result from natural fluctuations, response to prescribed medical treatments or other influences. Patients’ self–reported their health behaviours, and therefore potentially an overly positive picture may have been presented in an effort to please their keyworkers. The recruitment process may also have introduced selection bias and the sparseness of data relating to blood tests may have resulted in lack of power and therefore statistical significance may be affected.
Despite the methodological limitations of this study, the results demonstrate that enhanced physical health screening using the HIP is feasible and acceptable in this setting; if at the very least such screening programmes prevent deterioration in physical health then this would be a clinically meaningful outcome. In terms of future research, this study shows that it is possible to recruit and retain patients with SMI in health screening studies, and as clinicians were able to use the HIP to integrate relatively inexpensive health screening into routine clinical practice it would be sensible conduct further studies which utilise a randomised controlled trial design and employ a randomised recruitment strategy.
Annual health checks using the HIP are useful in monitoring the physical health of patients with SMI and are also effective in identifying individualised targets for clinical intervention. The results show that over the 12-month duration of the study the amounts of self-reported exercise improved and the numbers of patients prescribed diabetes medications reduced, but mean waist circumference increased. In this instance the enhanced screening programme does not seem to have significantly improved patients’ cardiovascular risk factors, but may have resulted in the prevention of further health deterioration.
This study was not supported by any external funding body. We would like to thank the CPNs and patients who participated in this study.
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