Body mass index and metabolic parameters in patients with schizophrenia during long-term treatment with paliperidone palmitate

Table 3 HOMA-IR and HOMA-%β values (geometric mean and range) at TR baseline, DB and OLE endpoints

	Underweight <19 kg/m²	Normal-weight 19- < 25 kg/m²	Overweight 25- < 30 kg/m²	Obese ≥30 kg/m²	Overall
HOMA-IR
TR baseline
N	22	191	200	133	546
Geometric Mean	1.5	1.7	2.4	4.3	2.4
Range	(0.66, 3.56)	(0.74, 3.99)	(1.11, 5.14)	(1.86, 9.85)	(0.99, 5.85)
DB endpoint
N	4	62	60	52	178
Geometric Mean	2.5	2.0	2.6	3.8	2.6
Range	(0.75, 8.17)	(0.84, 4.64)	(1.13, 5.80)	(1.64, 8.86)	(1.09, 6.33)
OLE endpoint
N	8	76	71	40	195
Geometric Mean	1.9	2.0	2.6	4.2	2.6
Range	(0.73, 4.81)	(0.78, 5.03)	(0.99, 6.97)	(2.19, 8.25)	(1.00, 6.56)
HOMA-%β
TR baseline
N	22	191	200	133	546
Geometric Mean	90.4	93.8	123.4	175.9	120.7
Range	(50.65, 161.25)	(46.18, 190.64)	(63.20, 240.9)	(82.53, 374.68)	(57.47, 53.47)
DB endpoint
N	4	62	60	52	178
Geometric Mean	84.7	100.2	105.9	167.1	118.1
Range	(21.50, 333.65)	(46.54, 215.73)	(59.91, 187.1)	(88.5, 315.3)	(57.8, 241.2)
OLE endpoint
N	8	76	71	40	195
Geometric Mean	117.0	91.0	100.8	167.9	108.2
Range	(50.71, 270.77)	(35.65, 232.06)	(47.68, 213.29)	(91.04, 309.64)	(46.99, 49.21)

TR- transition; DB- double-blind; OLE- open-label extension.
HOMA-IR = Homeostatic Model Assessment for Insulin Resistance; HOMA-%β = Homeostatic Model Assessment for β-cell function. *HOMA-IR and HOMA-%β are expressed as the Geometric Mean (exp [mean {logs} – 1 * SD {logs}], exp [mean {logs} + 1 * SD {logs}]).

ISSN: 1471-244X