White matter abnormalities in adolescents with generalized anxiety disorder: a diffusion tensor imaging study

BMC Psychiatry

Table 2 Regions of reduced white matter FA in adolescent GAD patients compared with healthy controls (p < 0.05, TFCE-corrected)

Cluster index	Anatomic location	L/R	Cluster size	Peak coordinates
				x	y	z
1	Uncinate fasciculus, Inferior fronto-occipital fasciculus, Inferior longitudinal fasciculus, Superior corona radiate, Anterior limb of internal capsule, Superior longitudinal fasciculus	L	2778	−40	−15	−13
2	Uncinate fasciculus, Inferior fronto-occipital fasciculus, Inferior longitudinal fasciculus, Posterior corona radiate, Posterior limb of internal capsule	R	1766	28	−17	23
3	Uncinate fasciculus, Inferior fronto-occipital fasciculus	R	346	30	11	−8
4	Inferior fronto-occipital fasciculus, Posterior corona radiata	L	187	−33	−50	12
5	Uncinate fasciculus, Inferior fronto-occipital fasciculus	L	187	−38	17	−15
6	Inferior longitudinal fasciculus, Anterior corona radiate	L	130	−27	−50	20
7	Inferior longitudinal fasciculus, Inferior fronto-occipital fasciculus	L	111	−31	−43	−16

FA, Fractional anisotropy; GAD, Generalized anxiety disorder; TFCE, The threshold-free cluster enhancement; L/R, Left/right.

ISSN: 1471-244X