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Table 2 Model inputs: costs

From: Cost-effectiveness of asenapine in the treatment of bipolar disorder in Canada

 

Event cost ($)

Base-case

Lower bound

Upper bound

Treatment Costs

   

  Cost of annual treatment

   

  Asenapine

1,030.00

N/A

N/A

  Olanzapine [41]

1,871.00

1,316.00

2,426.00

-Cost of EPS management [42]

60.00

0.00

N/A

  Costs associated with long-term metabolic complications

 

Direct costs*

   

Diabetes

3,834.77

1,215.00

17,072.00

Hypertension

571.00

233.00

827.00

CHDs

   

  Fatal CHDs

7,093.20

775.00

52,617.00

  CHDs (Year 1)

2,481.24

818.00

8,819.00

  CHDs (Year 2–5)

1,146.11

360.00

5,795.00

Stroke

   

Fatal stroke

30,776.93

7,362.00

34,165.00

  Stroke (Year 1)

4,034.86

1,395.00

10,560.00

  Stroke (Year 2–5)

1,867.59

452.00

8,692.00

Productivity losses[28, 43]–[46]

   

  Diabetes

528.00

396.00

660.00

  Hypertension

119.00

89.25

148.75

CHDs

3,109.00

2,331.75

3,886.25

Stroke

4,322.00

3,241.50

5,402.50

Informal care[47]

   

Stroke

3,770.00

2,827.50

4,712.50

  1. *Estimated from the RAMQ database.