From: Cost-effectiveness of asenapine in the treatment of bipolar disorder in Canada
 | Event cost ($) | ||
---|---|---|---|
Base-case | Lower bound | Upper bound | |
Treatment Costs | Â | Â | Â |
  Cost of annual treatment |  |  |  |
  Asenapine | 1,030.00 | N/A | N/A |
  Olanzapine [41] | 1,871.00 | 1,316.00 | 2,426.00 |
-Cost of EPS management [42] | 60.00 | 0.00 | N/A |
  Costs associated with long-term metabolic complications |  | ||
Direct costs* | Â | Â | Â |
Diabetes | 3,834.77 | 1,215.00 | 17,072.00 |
Hypertension | 571.00 | 233.00 | 827.00 |
CHDs | Â | Â | Â |
  Fatal CHDs | 7,093.20 | 775.00 | 52,617.00 |
  CHDs (Year 1) | 2,481.24 | 818.00 | 8,819.00 |
  CHDs (Year 2–5) | 1,146.11 | 360.00 | 5,795.00 |
Stroke | Â | Â | Â |
Fatal stroke | 30,776.93 | 7,362.00 | 34,165.00 |
  Stroke (Year 1) | 4,034.86 | 1,395.00 | 10,560.00 |
  Stroke (Year 2–5) | 1,867.59 | 452.00 | 8,692.00 |
 |  |  | |
  Diabetes | 528.00 | 396.00 | 660.00 |
  Hypertension | 119.00 | 89.25 | 148.75 |
CHDs | 3,109.00 | 2,331.75 | 3,886.25 |
Stroke | 4,322.00 | 3,241.50 | 5,402.50 |
Informal care[47] | Â | Â | Â |
Stroke | 3,770.00 | 2,827.50 | 4,712.50 |