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Table 2 Model inputs: costs

From: Cost-effectiveness of asenapine in the treatment of bipolar disorder in Canada

  Event cost ($)
Base-case Lower bound Upper bound
Treatment Costs    
  Cost of annual treatment    
  Asenapine 1,030.00 N/A N/A
  Olanzapine [41] 1,871.00 1,316.00 2,426.00
-Cost of EPS management [42] 60.00 0.00 N/A
  Costs associated with long-term metabolic complications  
Direct costs*    
Diabetes 3,834.77 1,215.00 17,072.00
Hypertension 571.00 233.00 827.00
CHDs    
  Fatal CHDs 7,093.20 775.00 52,617.00
  CHDs (Year 1) 2,481.24 818.00 8,819.00
  CHDs (Year 2–5) 1,146.11 360.00 5,795.00
Stroke    
Fatal stroke 30,776.93 7,362.00 34,165.00
  Stroke (Year 1) 4,034.86 1,395.00 10,560.00
  Stroke (Year 2–5) 1,867.59 452.00 8,692.00
Productivity losses[28, 43]–[46]    
  Diabetes 528.00 396.00 660.00
  Hypertension 119.00 89.25 148.75
CHDs 3,109.00 2,331.75 3,886.25
Stroke 4,322.00 3,241.50 5,402.50
Informal care[47]    
Stroke 3,770.00 2,827.50 4,712.50
  1. *Estimated from the RAMQ database.