This article has Open Peer Review reports available.
The development of a randomised controlled trial testing the effects of an online intervention among school students at risk of suicide
© Robinson et al.; licensee BioMed Central Ltd. 2014
Received: 5 August 2013
Accepted: 15 May 2014
Published: 27 May 2014
Suicide-related behaviour among young people is of significant concern, yet little is known regarding the effectiveness of interventions designed to reduce risk among this population. Of those interventions that have been tested, cognitive-behavioural therapy appears to show some promise among young people with suicidal ideation. Internet-based interventions are becoming increasingly popular and have shown some effect in preventing and treating depression and anxiety in young people. However, to date there are no randomised controlled trials examining the impact of Internet-based Cognitive Behavioural Therapy among suicidal youth.
This is a randomised controlled trial testing the effects of Internet-based cognitive-behavioural therapy among suicidal high school students who have sought help from the school wellbeing team. The intervention comprises 8 modules of Cognitive Behavioural Therapy delivered online. The study has a staggered, two-year recruitment phase and participants are assessed at baseline, post intervention and 12 weeks later.
If effective the program has the ability to be readily adapted and delivered to a range of populations in a range of settings, at relatively little cost. It can also be adapted for mobile applications.
ACTRN12613000864729. Date registered: 05/08/2013
Suicide-related behaviours (SRB), including suicide attempts (SA) and suicidal ideation are common among young people. Up to 24% of 12–17 year-olds have reported suicidal ideation, and 7-11% have reported a 12-month prevalence of suicide attempt . These behaviours are one of the greatest concerns for Australian young people  and are associated with a range of negative outcomes including completed suicide and premature mortality via other causes [3, 4]. The prevention of suicide, and the development of a strategic research agenda targeting interventions for suicidal youth have both been cited as national priorities [5, 6], yet there remains a lack of high quality intervention research for suicidal individuals , including youth .
Depression is the most common risk factor for SRB. Suicidal youth are six times more likely to have a psychiatric disorder than non-suicidal youth [9–11]. The most common disorder is depression, with between 60 and 80% of young people having a diagnosis of depression at the time of a SA . Hopelessness has long been linked to increased suicide risk, including among young people, and is believed to mediate the relationship between depression and suicide-related behaviour [13, 14].
Notwithstanding this, not all suicidal young people experience symptoms of depression; therefore interventions that specifically target suicidal young people are required. Good evidence exists regarding the treatment of youth depression , but there is limited knowledge regarding effective interventions for suicide-related behaviour [7, 8]. Of the psychological approaches that have been tested Cognitive Behavioural Therapy (CBT) appears to be the most promising in terms of its ability to reduce suicidal ideation among adolescents and young adults, however further research is required .
CBT is used extensively in the treatment of adolescent depression  and is recommended as a first-line treatment for depressed youth . Components frequently used with depressed adolescents include: basic psycho-education; pleasant activity scheduling; cognitive restructuring; problem-solving; and relaxation training .
In response to the growing popularity of electronic means of communication, in particular among youth, CBT interventions are now routinely delivered via the Internet. Internet-based CBT has been shown to be an effective and cost-effective form of treatment for depression and anxiety among adults [18–24], and has the potential to be more accessible and less stigmatising than traditional, face-to-face models of therapy [25, 26]. It has also been shown to have the potential both to prevent and reduce symptoms of depression and anxiety in adolescents [27, 28].
Adherence has been highlighted as a particular issue with online interventions . There is evidence to suggest that programs that are password protected, practitioner prescribed and supported, tend to have higher rates of adherence, lower rates of attrition and better treatment outcomes than open access sites [23, 30].
Given that practitioner involvement appears to improve outcomes, and that school wellbeing staff are considered helpful by students when it comes to mental health-related difficulties , the development of an Internet-based CBT program that can be delivered by school wellbeing staff is a logical next step. Indeed schools are an obvious and accepted environment for implementing suicide prevention initiatives [11, 32–34].
Yet, despite the potential benefits of Internet-based CBT, there is virtually no research into the impact of Internet-based CBT on SRB. To date only one study specifically set out to test the effects of an Internet-based program among suicidal adults, and reported a reduction in SI , and two studies testing online interventions for depression also demonstrated a reduction in suicide-related outcomes [36, 37]. No studies have targeted suicidal youth.
In response to this, we have developed and piloted an Internet-based program for school students at risk of suicide called Reframe-IT. Reframe-IT has been specifically designed for young people, and unlike other Internet-based programs, is designed to be delivered and supported, by school wellbeing staff.
The program has been piloted with 21 young people from nine schools. Findings show a reduction in suicidal ideation, depressive symptoms and hopelessness , and an increase in problem solving and coping skills (Hetrick et al, forthcoming) over the course of the program. The data also show that the modules do not induce either distress or suicidal ideation, and overall participants report finding the program enjoyable and say that they would recommend it to a friend . The pilot study was small and uncontrolled, therefore the program requires testing in a randomised controlled trial to confirm its effectiveness.
The primary aim of this study is to examine whether or not participation in the Reframe-IT program leads to reduced: 1) suicidal ideation. Additional aims are to examine its impact on: 2) symptoms of depression, and 3) levels of hopelessness, among participating students, and to determine if it leads to: 4) increased confidence 5) increases in perceived skill, and 6) changes in practice among school wellbeing staff (in particular with regard to their use of Internet-based programs and resources with at-risk students).
The student-related aims listed above will be addressed via a randomised-controlled trial. The study has a staggered two-year recruitment phase and involves the delivery of eight modules of CBT delivered over a 10-week intervention period. Students are followed up post intervention and again 12 weeks later. The study has been designed in order that the CONSORT guidelines  can be met when reporting the trial.
The aims related to school staff will be assessed using a pre-test/post-test design.
The study team comprises a project coordinator (JR), a research therapist (SH); two research assistants; a clinical psychologist (SB), and a statistician (HPY).
All secondary schools in the study catchment area (north west metropolitan Melbourne) will be invited to participate. Up to 28 of the responding schools will be selected on a first-come first-served basis. Schools will be recruited in a staggered manner. Participants (n = 170) will also be recruited in a staggered manner, over a two-year period. In order to meet the inclusion criteria students must be aged 14 to 18 and report any level of SI in the past month. They must also provide written consent from themselves and their parents/guardians. Exclusion criteria are an intellectual disability, psychotic symptoms and/or inability to speak English. Participants will be recruited by members of the student wellbeing team at each school. All students who present to the school wellbeing staff member and meet the inclusion criteria will be asked if they are interested in hearing more about the study by that staff member. They will also be given a brief information sheet explaining the study, which they can read and share with their parents/guardian. If the student indicates that they would like to take part they are given a detailed information and consent form to take home to be signed.
The Reframe-IT intervention comprises eight modules to be delivered during the 10-week intervention period. Each participant will have access to his or her own personalised webpage accessed via secure login. For safety reasons, the program will be administered in the young person’s school by the student wellbeing staff member. Once each individual module has been completed in the presence of the school staff member, participants will be able to access it from home, 24 hours a day. The program has no social networking function.
The program takes the form of an adult ‘host’ character that delivers the therapy verbally, and a series of video diaries made by young people. There are two activities per week plus homework. The site has a message board through which the participant can communicate with the research-therapist; a series of factsheets covering a range of related topics, including managing suicidal thoughts; plus downloadable relaxation MP3s. As the weeks progress additional items are added to the site, (e.g. an activity diary). Finally there is a ‘Getting help’ tab, which lists a range of local and national helplines and services that the participant can access if in crisis.
The eight modules incorporate standard CBT approaches commonly used with young people but have a specific focus on suicidal thinking and behaviours : engagement and agenda setting; emotional recognition and distress tolerance; identification of negative automatic thinking; behavioural activation - help-seeking and activity scheduling (including relaxation techniques); problem solving; detecting and challenging problematic thinking, and cognitive restructuring.
Practitioner involvement will be two-fold. First, the SWC will facilitate delivery of the program (i.e. setting up appointments; managing Internet issues; and remaining in the vicinity while the participant views the program). They will also check responses to a weekly suicide screen and respond accordingly. Second, there will be involvement from the research therapist (SH) who will remain un-blinded. She will check completed activities and respond with personalised but standardised messages. She will also check the message board daily and respond accordingly.
The control group will receive Treatment As Usual only. This will be monitored via questionnaire, and a weekly client contact sheet completed with each school.
Participants will be assessed prior to delivery of the intervention (baseline), immediately post-intervention (10 weeks) and 12 weeks later. The research assistant will administer each of the following measures at each time point, with the exception of the evaluation questionnaire, which is only administered post-intervention. All assessments will be conducted at school.
The primary outcome is reduced suicidal ideation at post-intervention and follow-up, measured by the Suicidal Ideation Questionnaire (SIQ), a 30-item self-report measure designed to assess suicidal ideation in adolescents. It has been validated with clinical and non-clinical populations and shown to have high levels of internal consistency and test-retest reliability, and high levels of construct and criterion validity [41, 42].
Other outcomes to be measured include:
Suicidal acts - using a series of specifically-designed questions.
Depressive symptoms - using the clinician-rated Children's Depression Rating Scale-Revised (CDRS-R) , and the Reynolds Adolescent Depression Scale-2 (RADS-2) . The CDRS-R is a semi-structured interview schedule originally designed for use with children but also successfully used with adolescents. It rates depressive symptoms across 17 domains including difficulties with schoolwork, social withdrawal, appetite and sleep disturbance, fatigue, guilt and suicidal ideation. The first 14 items are rated on the basis of responses to interview questions from the young person, and are rated for the past two weeks and currently. The remaining three symptom areas (depressed facial affect, listless speech and hypoactivity) are rated by the clinician on the basis of the participant's non-verbal behaviour. Each symptom is graded on a 5 or 7-point scale with increasing scores indicating increasing severity of symptoms. The total score, or CDRS-R score, is the sum of all 17-item scores and the instrument has a range of 17-113. This scale is used widely, has adequate internal reliability, good test-retest reliability, good to excellent inter-rater reliability and is sensitive to treatment effects [43, 45]. The RADS-2 is 10-item brief screening measure for the assessment of current depressive symptoms in adolescents aged between 11 and 20. It can be used in clinical or non-clinical populations and takes around 2-3 minutes to complete. Items assess mood or reduced affect, loneliness, social withdrawal, sadness, self-harm, self-reproach, self-worth, anger/irritability, loss of interest and helplessness. Participants are asked to rate how often they experience each item on a 4-point Likert scale ranging from ‘almost never’ to ‘most of the time’. Responses are rated from 1-4, giving a possible total score range of 10-40 points, with higher scores indicating greater symptom severity. The instrument includes one reverse-scored item that is worded in a positive manner, so that reversing the individual’s score represents greater depression. A cut-off score of 26 on this measure indicates clinically significant symptomatology. The RADS-2 has demonstrated strong internal consistency and a moderately high level of test-retest reliability among school students. It has also demonstrated strong evidence of criterion validity when assessed against both clinical interview and self report measures of depression, and strong construct and clinical validity [44, 46].
Hopelessness will be measured using the Beck Hopelessness Scale . This is a self-report scale consisting of 20 true or false items, 9 or which are keyed ‘false’ and 11 are keyed ‘true’. For every statement, each response is assigned a score of 0 or 1, and the total ‘hopelessness score’ was the sum of the scores on the individual items. Thus, the possible range of scores was from 0 to 20, with a higher score indicating a greater degree of hopelessness. A cut-off score of 9 on the scale has been found to be predictive of eventual suicide among clinical samples . This scale has been found to have a high degree of internal consistency and good test-retest reliability and good construct and concurrent validity.
Anxiety will be measured using the Multidimensional Anxiety Scale for Children . This is a 39-item self-report instrument that assesses the major aspects of anxiety in young people. Items are distributed across four dimensions: physical symptoms, harm avoidance, social anxiety and panic. Participants are asked think about how they have been feeling recently and to rate each item on a 4-point scale of 0-3 ranging from this is ‘never true about me’ to this is ‘often true about me’. Scores are derived from totals on each subscale together with those from a total anxiety scale, an anxiety disorders index and an inconsistency scale. Detailed instructions on scoring and interpretation are provided in the user manual. The MASC has shown adequate internal consistency and satisfactory test-retest reliability. It also has strong discriminant validity and moderate construct validity .
Problem-solving skills will be assessed using the Negative Problem-Oriented Questionnaire . This is a 12-item self-report measure that assesses negative problem orientation. Participants are asked to rate their responses on a 5-point scale with responses ranging from 1 – ‘not at all true of me’ to 5 – ‘extremely true of me’. The measure is unifactorial with no inverted questions. A higher score indicates a greater degree of negative beliefs concerning one’s problems and problem-solving ability. The scale has demonstrated excellent internal consistency, good test–retest reliability at five weeks, and both convergent and discriminant validity when measured against self-reported pessimism, depression, anxiety, and problem-solving ability.
The Cognitive-behavioural Therapy Skills Questionnaire  will be used to test which components of the CBT appear to be most active. This 16-item scale measures the use of cognitive restructuring and behavioural activation skills i.e. changes in avoidance/behavioural control and changes in cognitive style. Respondents rank each item on a 5-point Likert scale from 1 (I don’t do this) to 5 (I always do this). It is a relatively new measure but it has been shown to be both reliable and valid.
Distress will be measured using the abbreviated version of the Profile of Moods States (POMS) [52, 53]. The POMS is a 14-item self-administered checklist measuring transient mood states. This measure has been used previously with adolescents for this purpose  and has been demonstrated to be sensitive to short-term change [52, 53]. The POMS data can be used to produce the following six subscales: anger, depression, fatigue, tension, confusion and vigour. The score of each item ranges from 0-4. Each subscale is scored by adding up the scores of the related items and a higher score reflects greater presence of that item.
At baseline, demographic information will be collected using a specifically designed questionnaire, and the first four subscales of the Comprehensive Assessment of At-risk Mental State (CAARMS) , to screen for psychosis. The CAARMS is a semi-structured clinician administered interview schedule that was specifically designed to assess for signs of psychosis in young people. It includes eight subscales that measure disorders of thought content; perceptual abnormalities; conceptual disorganisation; motor changes; concentration and attention; emotion and affect; subjectively impaired energy and impaired tolerance to normal stress. Scores for each subscale range from 0-6 with a higher score indicating greater likelihood of a psychotic disorder being present. It has been found to have good to excellent concurrent, discriminant and predictive validity and excellent inter-rater reliability.
To test for possible confounders the following will also be assessed:
Treatment history - using a specifically developed questionnaire.
Substance use, via the Substances and Choices Scale , which is a one-page self-report questionnaire designed for young people aged 13-18 years and takes about 5 minutes to complete. It has three sections. The first section records the number of occasions the young person has used a variety of substances in the last month. The second section measures both substance use related symptoms and substance related harm. Scoring this section yields the ‘SACS difficulties score’ from 0 to 20. This score can be used to screen or measure change through a treatment episode. The third section asks about tobacco use. It has been shown to demonstrate good reliability and validity.
Help seeking via the General Help Seeking Scale . The General Help Seeking Scale measures help-seeking intentions, appraising both formal and informal sources. Participants rate help-seeking intentions ranging from 1 (‘extremely unlikely’) to 7 (‘extremely likely’) for each help source option including ‘no one’. Higher scores indicate higher intentions.
Participant satisfaction and the extent to which they find the program acceptable will be measured using a specifically designed measure at post-intervention.
All outcome measures with the exception of the CDRS-R will be administered online. Research staff will receive training in the administration of the CDRS-R by one of the two clinical psychologists on the study team. All research staff will also be trained in the assessment of suicide risk.
School staff outcomes
These will be measured using a specifically designed questionnaire, based on those previously used by this research team . This will be administered prior to the beginning of each school’s involvement in the study and at the end of the intervention period. If a staff member leaves the school before the end of the study they will be asked to complete the questionnaire before their departure. The questionnaire will assess attitudes, confidence; perceived skill and changes in practice.
All outcome data will de-identified and stored on a password-protected database located on a secure server housed by Orygen Youth Health Research Centre.
Participants (n = 170) will be recruited via each school’s student wellbeing coordinator. Once written consent is obtained from a potential participant, a baseline assessment will be conducted to ascertain his or her eligibility. The study coordinator (JR) will randomise eligible participants into either the treatment or control group using a randomisation list prepared by an independent statistician. The randomisation list (generated using random number generator computer software) is stratified by school and is incorporated into an online randomisation computer program. Immediately after each randomisation, the relevant school wellbeing staff member will be automatically notified of treatment allocation via email. They will then administer the appropriate treatment to the participant.
Blinding and treatment fidelity
Because of the nature of the intervention (i.e. it is to be delivered by school staff) it is not possible for school staff to be blind to intervention. In addition, the study coordinator (JR) and the two study psychologists (SH and SB) will remain unblinded in order that randomisation can be conducted and to enable the website to be moderated. However the research assistants conducting outcome assessments and the statistician conducting the analysis will remain blinded to treatment allocation until study completion.
With regard to treatment fidelity, a study manual has been developed to facilitate this across sites. However it is acknowledged that the same school staff will be administering both the treatment and control interventions to students. Therefore there is the possibility of some contamination, in terms of school wellbeing staff incorporating some of the techniques from the CBT program into their work with students allocated to the control condition. However we consider this to be unlikely. Although school staff will be responsible for administering the program, they will not be required to supervise the student closely whilst they watch the program. Rather their role will be to set up appointments with the students, to remain in the vicinity whilst each module is completed, and to check the suicidal ideation screen at the end of each module. However in order to assess this we will ask all school wellbeing staff to complete a short checklist at the end of each session with a Reframe-IT student that will record the length and content of each session.
At each follow-up time point the general linear model will test for the treatment factor, i.e. compare the intervention and control groups for each outcome measure. Corresponding baseline values of each outcome measure will be used as the covariate. In addition, possible effect of site will be examined by introducing a school factor in the analysis. Multi-level modeling will be used to compare the two groups in terms of the trend over time for each outcome. Both the last observation carried forward and multiple imputation techniques will be considered if missing data are substantial. Interim analysis will be conducted twice yearly, or upon request to facilitate the safety monitoring of the project.
Adherence will be measured using data automatically collected by the system (e.g. number of times each participant logs onto the site, amount of time spent on the site, proportion of activities completed).
School staff outcomes
Descriptive statistics (mean, SD, median) will be used to gauge the level of confidence and perceived ability at baseline and post-intervention. Paired t-test will be used to test if there is a significant change between baseline and follow-up. The general linear model will also be used to examine if the changes are related to possible covariates such as baseline levels and previous training.
Effect size and statistical power
The primary outcome of interest is changes in suicidal ideation from baseline measured at 10 and 22 weeks. This will be measured by the SIQ. No previous studies have tested the effects of an Internet-based CBT intervention on suicidal ideation, however one previous study  has reported moderate to large effect sizes in terms of reduced suicidal ideation, for face-to-face CBT among young people. If we assume that alpha is set at 0.05 and power at 0.80, then a sample size of 58 is required for each of the two groups (total n = 116) to detect a medium effect size. This is based on using the general linear model to compare the intervention and control groups with the baseline values of an outcome measure as the covariate. It is assumed (conservatively) that the covariate would explain 10% of the variance in the dependent variable. Using data from the pilot study, the intra-cluster correlation corresponding to the schools is estimated to be 0.023, which in turn gives an estimate of 1.1 for the design effect. So in order to take account of the clustering effect of the schools, the sample size needs to be inflated to 128 (116 × 1.1).
A previous RCT conducted by the study team with a similar population had a dropout rate of 24% . The proposed study differs in that the intervention will be delivered by school staff and all follow-up assessments will be conducted at school. It will also employ a shorter follow-up period, however we have estimated a dropout rate of 24% meaning that we need to recruit 169 students (128/0.76) into the study. We estimate that we can recruit about 6 students from each school, so we need to recruit 28 schools. Based on data obtained from a pilot study conducted prior to developing the RCT  we consider these figures to be feasible.
Every effort will be made to promote participant retention, including close liaison with school staff, maximum flexibility on the part of research staff conducting follow-up assessments, and by employing a number of methods to contact students for follow-up assessments. These will include contacting the participant via the school wellbeing coordinator in the first instance, but also by contacting them directly via phone or email and contacting them via their parents/guardians if necessary.
Ethics and safety
Ethical approval has been obtained from the University of Melbourne Human Research and Ethics Committee.
Protocols and supervision
Clear and detailed safety protocols have been developed for this study detailing how undue risk will be determined and how the research team will respond. The research assistants will receive training in the administration of the measures and in the assessment of suicide risk. The research assistant will make contact with the school wellbeing staff member once each assessment is completed. If the research assistant and the school are concerned about the participant the project coordinator will be informed and, where necessary, an immediate referral will be made to an appropriate service. Fortnightly supervision meetings with the research therapist and the clinical psychologist will be held, during which all cases will be presented and any diagnostic and/or risk issues discussed.
In addition, participants will complete a weekly suicidal ideation screen, which will be checked by the school wellbeing staff member at the end of each session. If a participant indicates current suicidal ideation, a risk assessment will be conducted. If they are determined to be at elevated risk then the staff member will be required to follow the school’s safety protocols. They will also receive an automated email prompting them to follow these procedures.
The website will be moderated on a daily basis five days a week during the school term by the clinical psychologist and clear procedures have been established to manage any indication of risk. It will be made clear to all participants that the website will not be moderated seven days a week, 24 hours per day, therefore if urgent messages are posted on the site they may not be seen for a couple of days. The website will include information about appropriate sources of help in a crisis and participants will be encouraged to use these contacts when necessary instead of contacting the research team.
An independent safety advisory committee will oversee all safety procedures. If at any point during the trial the committee is concerned about the welfare of participants as a result of their participation in the study, they will have the capacity to suspend the trial.
All data collected will be stored securely and according to the University of Melbourne’s Policy on the Management of Research Data and Records.
This paper describes the development of a randomised controlled trial that aims to examine the efficacy of an online CBT intervention to reduce suicide risk in secondary school students.
As noted above, there is limited evidence regarding the effectiveness of interventions for this population. Evidence from randomised controlled trials is particularly lacking , and although there are a range of valid reasons for the limited number of controlled trials in the field of suicidology , they remain the gold standard means of testing the effectiveness of interventions. Therefore RCTs are required if we are to establish effective interventions for at-risk youth.
One of the reasons postulated for the lack of randomised controlled trials with this population relate to sample size issues . Others relate to ethical concerns surrounding withholding potentially efficacious interventions to youth at risk, as well as fears that asking young people about suicide-related thoughts or behaviours will cause distress and increase subsequent risk. Together these factors have meant that suicidal youth are often excluded from research into face-to-face therapy , as well as from studies testing Internet-based interventions .
However, research has indicated that conducting research with this population can be both safe and acceptable [31, 39, 54, 63]. In addition, Internet-based interventions such as this have the capacity to reach large numbers of people . Yet, despite this, and despite the extent of the problem of suicide-related behaviours in young people, to our knowledge, this project is the first internationally to test an Internet-based intervention specifically among young people at risk of suicide.
This program differs from other Internet-based CBT programs in that it uses a series of video diaries as opposed to being text-based. It also specifically addresses SRB within the modules, and it is practitioner-administered. It was noted above that programs that are practitioner administered tend to have higher rates of adherence and engagement than open access programs [23, 30]. However this does mean that the program relies on young people seeking help from a school wellbeing staff member and it makes the program more resource intensive than other programs. However, given the fact that participants in this program are at risk of suicide the benefits associated with practitioner involvement are believed to outweigh the potential drawbacks.
We do acknowledge that attrition may still be a problem. Every effort will be made to promote participant retention, including close liaison with school staff, maximum flexibility on the part of research staff conducting follow-up assessments, and by employing a number of methods to contact students for follow-up assessments. These will include contacting the participant via the school wellbeing coordinator in the first instance, but also by contacting them directly via phone or email and contacting them via their parents/guardians if necessary.
The program is highly transferable and easy to implement, meaning that, if effective it could readily be adapted and made available to a range of high-risk populations across a number of settings (either as an add-on or alternative to face-to-face treatment). It also has the capacity to reach rural and remote areas, where access to services can be limited and to be adapted for mobile applications. Indeed, as much of the cost of such an intervention is associated with the development and initial testing, once evaluated it has the potential to be adapted and rolled out to large numbers of people with ease and at relatively little cost.
The study is being funded by a beyondblue Victorian Centre of Excellence grant. The pilot study received funding from the American Foundation for Suicide Prevention and from an NHMRC Program Grant. JP is on a National Health and Medical Research Council Senior Research Fellowship. SH and SB are both on a National Health and Medical Research Council Early Career Fellowship. OYHRC is affiliated with Melbourne Health and the University of Melbourne and receives funding from the Colonial Foundation.
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