- Research article
- Open Access
- Open Peer Review
Psychometric properties of a sign language version of the Mini International Neuropsychiatric Interview (MINI)
© Øhre et al.; licensee BioMed Central Ltd. 2014
- Received: 20 September 2013
- Accepted: 9 May 2014
- Published: 22 May 2014
There is a need for psychiatric assessment instruments that enable reliable diagnoses in persons with hearing loss who have sign language as their primary language. The objective of this study was to assess the validity of the Norwegian Sign Language (NSL) version of the Mini International Neuropsychiatric Interview (MINI).
The MINI was translated into NSL. Forty-one signing patients consecutively referred to two specialised psychiatric units were assessed with a diagnostic interview by clinical experts and with the MINI. Inter-rater reliability was assessed with Cohen’s kappa and “observed agreement”.
There was 65% agreement between MINI diagnoses and clinical expert diagnoses. Kappa values indicated fair to moderate agreement, and observed agreement was above 76% for all diagnoses. The MINI diagnosed more co-morbid conditions than did the clinical expert interview (mean diagnoses: 1.9 versus 1.2). Kappa values indicated moderate to substantial agreement, and “observed agreement” was above 88%.
The NSL version performs similarly to other MINI versions and demonstrates adequate reliability and validity as a diagnostic instrument for assessing mental disorders in persons who have sign language as their primary and preferred language.
- Mental disorders
- Psychiatric diagnoses
- Hearing loss
- Sign language
Language and communication are fundamental for diagnosing most mental disorders. Most assessment instruments are designed for use with hearing individuals, and many deaf and severely hard-of-hearing people with psychiatric illness may receive incorrect diagnoses because of challenges in communication between patients and professionals [1–3]. The resulting lack of diagnostic precision may have serious bearing on treatment adequacy and quality. In Norway and other countries, there is a need for valid and reliable instruments for assessment of mental disorders in deaf and severely hard-of-hearing persons who have sign language as their primary and preferred language (signers).
The Mini International Neuropsychiatric Interview (MINI) was developed to meet the need for a brief and reliable structured diagnostic interview in clinical practice as well as in research [4, 5]. In clinical practice, the MINI is considered a supplement and not a substitution for regular diagnostic intake interviews. It is a structured evaluation of most of the major psychiatric conditions [4, 5], and was therefore selected for translation into Norwegian Sign Language (NSL).
The MINI includes 23 disorders from the tenth revision of the International Classification of Diseases and Related Health Problems (ICD-10)  and from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV) . It is organised in diagnostic sections with branching tree logic and two to four screening questions with yes or no responses for each disorder. Additional symptom questions are asked only when a screening question is endorsed [4, 8]. Excellent inter-rater and test-retest reliabilities have been reported for the English and French versions , as well as good to very good convergent validity relative to the Composite International Diagnostic Interview, CIDI  and the Structured Clinical Interview for Diagnostic and Statistical Manual, SCID . In test-retest analyses, kappa values have indicated excellent agreement according to Fleiss  for six diagnoses, fair to good agreement for six diagnoses and poor agreement for seven diagnoses, whereas observed inter-rater agreement has been 75% or above .
When a psychiatric diagnostic instrument is translated into a new language, reassessment of validity and reliability is necessary. Wordings that seem identical in different languages may nonetheless be differently interpreted, especially when a written text is translated to a sign language [11, 12]. This is not just a matter of semantic divergences, but also of divergences related to cultural understanding of concepts, words (signs) and sentences. Development of expressions that both convey the question’s core content and appear meaningful to the patient is vital.
Studies on the validity and reliability of the MINI
Study & language
Results, depressive and anxiety disorders
Concordance; Cohen’s kappa mean & range
Sheehan et al.  English
Psychiatric patients N = 308 Non-patients, N = 62 Total N = 370
Test-retest and inter-rater analyse
Concordance between MINI-CR and SCID-P1 diagnoses
Twenty-two diagnostic categories analysed
Major depressive disorder kappa:0.84, observed agreement: 92%
Two diagnoses occurred in less than 5% of participants
Inter-rater (kappa) 1.00, Retest (kappa) 0.87 Lifetime panic disorder, kappa: 0.80, observed agreement: 91%
Kappa mean: 0.67, range: 0.43-0.90
Inter-rater (kappa)0.97, Retest (kappa) 0.79
Lecrubier et al.  French
Psychiatric patients N = 260 Non-patients, N = 50 Total N = 310
Test-retest and inter-rater analyses
Concordance between MINI and CIDI2 diagnoses
Seventeen diagnostic categories analysed
Major depressive disorder (kappa) 0.73, observed agreement: 87% Test-retest (kappa) 0.83
Four diagnoses occurred in less than 5% of participants
Lifetime panic disorder (kappa) 0.68, observed agreement: 92% Test-retest (kappa) 0.76.
Kappa mean: 0.66, range: 0.36-0.82
Inter rater, all diagnoses (kappa) 0.88-1.00
Bobes  Spanish
Primary health care patients N = 126
Major depression, sensitivity 0.94, specificity 0.62
No Cohen’s kappa values available
Generalised anxiety disorder, sensitivity 0.92, specificity 0.65
Pinninti et al.  English
Psychiatric outpatients N = 111
Diagnostic agreement in 58% of the cases In 33% the disagreement was of substantial nature MINI diagnosed more co-morbid conditions
No Cohen’s kappa values available
Rossi et al.  Italian
Psychiatric outpatients N = 50
Inter-rater and test-retest analyses
Major depressive disorder, current: Inter-rater reliability (kappa) 0.96. Test-retest (kappa) 0.46
Thirty-one diagnoses analysed Inter-rater kappa mean: 0.85, range: 0–1.00
Major depressive disorder, recurrent: Inter-rater reliability (kappa) 0.84. Test-retest (kappa) 0.36
Test-retest kappa mean: 0.41, range: 0–1.00
Panic disorder lifetime: Inter-rater reliability (kappa) 0.88. Test-retest (kappa) 0.49
Information on diagnoses occurring in less than 5% of participants not available
Kadri et al.  Moroccan
Psychiatric patients N = 175 Non-patients, N = 50 Total N = 225
Inter-rater and test-retest analyses
Concordance between MINI and expert diagnoses Major depressive disorder (kappa) 0.95, observed agreement: 99%
Thirteen diagnostic categories analysed Four diagnoses occurred in less than 5% of participants
Social phobia (5% of participants) (kappa) 0.91, obs. agreement: 94%
Kappa mean: 0.91, range: 0.79-0.95
Inter-rater and test-retest reliability (kappa) all above 0.80
Otsubo et al.  Japanese
Psychiatric inpatients AN = 82 BN = 169
ASCID-P1 B Expert opinion
Inter-rater and test-retest analyses
Concordance between MINI and A SCID-P1/B expert opinion
A Thirteen diagnostic categories analysed Four diagnoses occurred in less than 5% of participants
Major depressive disorder,
Kappa mean: 0.71, range: 0.49-0.93
A kappa: 0.85, obs. agreement: 93%
B Eleven diagnostic categories analysed Seven diagnoses occurred in less than 5% of participants
B kappa: 0.36, obs. agreement: 69%
Kappa mean: 0.34, range: 0.03-0.69
Panic disorder, A kappa: 092, obs. agreement: 98%
B kappa: 0.53, obs. agreement: 89%
MINI test-retest, kappa: 0.80, obs. agreement: 91%
MINI Inter-rater, kappa: 0.94, obs. agreement: 97%
Marques & Zuardi  Portuguese
Primary health care patients N = 120
Concordance between MINI and SCID3 diagnoses Depressive disorders, kappa: 0.75, obs. agreement: 92%
Eight diagnostic categories analysed Four diagnoses occurred in less than 5% of participants
Anxiety disorders, kappa: 0.81, obs. agreement: 94%
Kappa mean: 0.66, range: 0–0.85
Mordal et al.  Norwegian
Psychiatric patients, acute ward N = 38
Test - retest analysis
Concordance of MINI diagnoses in test-retest
Twenty diagnostic categories analysed Six diagnoses occurred in less than 5% of participants
Major depressive episode, kappa: 0.82, obs. agreement: 92%
Kappa mean: 0.51, range: 0–1.00
Panic disorder, lifetime, kappa: 0.84, obs. agreement: 92%
Sign languages are natural languages that have evolved through use by deaf and hard-of-hearing people. Utterances are produced with the hands and face and are visually received and decoded [20, 21]. Sign languages share many linguistic characteristics with spoken languages, but also have characteristics that are specific to the manual-visual modality [20, 21]. Most deaf adults use written language and consider it their second language; however, a considerable percentage of congenitally deaf people struggle with written texts [22, 23].
To reliably diagnose mental illness in signing persons, clinicians must have sufficient sign language competence and thorough knowledge of deaf culture. They must also have a deep understanding of the potential psychosocial consequences of profound hearing loss, the accompanying language and communication challenges, and the obstacles encountered by many deaf and hard-of-hearing people in society. If these requirements are not met, clinicians may misinterpret the patient’s utterances as symptoms of mental illness or thought disturbances, or may overlook symptoms of mental illness because they are not communicated in the expected manner.
The present study investigates the functionality of a NSL version of the MINI. The main research question is whether this version functions in the same manner with signing deaf and hard-of-hearing patients as do other versions of the MINI with hearing patients.
The present investigation is part of a comprehensive study of mental health in individuals referred to specialised psychiatric units for deaf and severely hard-of-hearing patients, and includes patients using different modes of communication and language.
Deaf and severely hard-of-hearing signers who were referred to the unit for adults at the National Centre for Mental Health and Hearing Impairment, Oslo University Hospital and the Regional Centre for Mental Health and Hearing Impairment, St. Olav’s Hospital, Trondheim were asked to participate in the study. Exclusion criteria were age below 18 years, spoken language as the main form of communication, dual sensory loss requiring tactile communication, acute and severe psychiatric or somatic illness, and referral for reasons other than assessment of mental disorder. Information was given in NSL or other forms of visual communication preferred by the person, and written consent was obtained from those who decided to participate.
Participant information (N = 41)
Number of females
Age in years
mean: 36, SD 14.1, median: 34, range: 18–83
Decibel loss in the better ear
mean: 84.9, SD 13.8, median: 90, range: 56–110
Married and cohabiting
Divorced, separated & widowed
High school and equivalent
College degree and above
Source of income
Paid work and study loans
Social welfare and pension
1GAF F at admission
mean: 55.2, SD 12.4, median: 52, range: 31–76
2GAF S at admission
mean: 55.5, SD 11.0, median: 56, range: 21–73
The assessments applied in this study were identical to the ordinary diagnostic assessments at intake. The results were documented in case notes from which personal identifiers had been removed. The diagnoses in these case notes were used to validate the diagnoses assessed by the NSL version of the MINI.
The MINI 5.0.0 was translated from Norwegian into NSL in 2008–2009 through an agreement with Dr. Ulrik Malt, who was leading the team that translated the MINI from English to Norwegian . The translation was performed in accordance with internationally acknowledged translation procedures [25, 26] as well as specific procedures suggested for translating written and spoken material into sign language [11, 22, 27]. A bilingual team of hearing and deaf clinicians and researchers translated each item into sign language and sent video-recordings to deaf and hearing bilingual professionals not familiar with the original text, who back-translated the items into written Norwegian. The research team compared the back-translations to the original written text, and if a back-translated item did not correspond to the content and intent of the original item, the item was discussed and rephrased. Consensus regarding the original text and back-translations was obtained before any item was included in the final video-recorded version. The video-recorded version was subsequently used to instruct and train the experienced MINI assessors, who were signers, to pose the questions of the MINI through uniform Norwegian Sign Language expressions.
Clinical interview (Expert opinion)
The standard intake interview used at Oslo University Hospital, Clinic of Mental Health and Addiction, was used as expert opinion. It was extended to include questions about background factors and life events that may affect the participant’s vulnerability to a mental disorder. These questions include cause of hearing loss, primary language and communication mode, communication environment in childhood, educational setting and experiences related to growing up with hearing loss.
The clinical interview was conducted by clinical psychologists and psychiatrists, who had long experience with deaf and severely hard-of-hearing patients, were skilled in sign language, and had extensive knowledge about deafness and deaf culture. The communication with the participants was in NSL and was adapted to match the communication style of the participant as needed. The MINI interview was conducted in NSL by experienced MINI assessors.
Each participant was first seen by the team that would conduct the clinical intake interview (expert opinion). The MINI assessment was completed by another team consisting of a deaf therapist who is a native signer who posed the questions to the patients, and either a psychiatrist or a specialised clinical psychologist who guided the deaf co-therapist and the participant through the MINI interview and made the diagnostic decisions. Sometimes, the latter professional would also ask questions to obtain additional information. The two diagnostic teams received the referral information but did not share other information, and were blind to each other’s diagnoses. The two assessments were scheduled with minimal time lag between them. All assessment sessions were video-recorded, except those for three participants who did not want to be recorded.
To ensure that the clinical intake interviews were in fact appropriate to serve as expert opinion for validating the MINI, inter-rater reliability was computed. Eleven (27%) of the recorded clinical interviews were reassessed by a clinical psychologist who was familiar with the patient population and skilled in NSL. He received the referral information and made assessments based on the videotaped interviews, but was blind to the diagnoses given in the assessment. The same procedures were used to compute inter-rater reliability for eight (20%) of the MINI interviews. The patients were drawn randomly, but because the psychologist had to be blind to the person’s diagnoses, the same patient could not be reassessed twice. To prevent resampling, the patients whose intake interviews had been used for reassessment were excluded before the random subsample was drawn.
Study inclusion required informed consent. Participants were informed that they could withdraw from the study at any time and have their videos erased, without any consequences for their treatment. Any participant who might experience additional burden as a result of participation in the study would be offered appropriate support and counselling. The study was approved by the Regional Committee for Medical and Health Research Ethics (REK) and the Norwegian Data Protection Authority (NDPA).
SPSS version 20 was used to analyse the data. Cohen’s kappa was calculated to assess inter-rater reliability and to estimate the validity of the diagnoses assessed by the MINI. According to Shrout , kappa values above 0.80 indicate substantial agreement, 0.61–0.80 moderate agreement, 0.41–0.60 fair agreement, 0.11–0.40 slight agreement, and below 0.10 virtually no agreement. Approximate 95% confidence intervals were generated by multiplying the standard error of kappa by 1.96. The observed agreement was the frequency of two raters’ agreement on whether a disorder was present .
The mean length of the MINI interview was 58 min (range 32–88). The most prevalent diagnoses assessed by expert opinion were major depressive disorder (n of diagnoses = 22; 54%) and anxiety disorder (n of diagnoses = 12; 29%). No participant met the criteria for mania, agoraphobia, obsessive compulsive disorder, anorexia nervosa or bulimia nervosa.
Twenty-eight participants (68%) received a diagnosis by both expert opinion and the MINI, with an average of 1.2 diagnoses according to expert opinion and 1.9 according to the MINI. Thirteen participants (32%) did not meet the criteria for any diagnosis on the MINI. Two of them did not receive a diagnosis by expert opinion—four were considered to have major depressive disorder—and seven were diagnosed with disorders of psychological development, mild mental retardation, personality disorder or disorder of severe stress and adjustment, which are included in ICD 10, but not in the MINI.
There was agreement about 49 (64%) of the 77 diagnoses given to the 41 participants.
In five conditions (6%) MINI gave no diagnosis and expert opinion assessed major depressive disorder, and in 13 conditions (17%) with a MINI diagnosis expert opinion assessed “no diagnosis”. Nine conditions (12%) were assigned a diagnosis included in the MINI by the MINI interview and a diagnosis not included in the MINI by the clinical interview. Last, there was major disagreement about one condition (1%), which was diagnosed as drug dependence by the MINI and as major depressive disorder by expert opinion (Additional file 1: Table S1).
Concordance between the Norwegian sign language version of the MINI and expert opinion, all patients’ diagnoses (N = 41)
Disorders assessed in the present study (sorted as in MINI)
Cohen’s kappa (95% CI)
Major depressive disorder
Social anxiety disorder
Posttraumatic stress disorder
Alcohol dependence & abuse
Generalised anxiety disorder
Antisocial personality disorder*
Concordance between the Norwegian sign language version of the MINI and expert opinion, all patients’ diagnoses (N = 41)
Cohen’s kappa (95% CI)
Twenty-six per cent of the participants underwent the two diagnostic interviews during the same day. The median number of days between the two interviews was 19 (range 0–115). The point estimate of Cohen’s kappa for depressive disorders was 0.46 for all participants, 0.50 for those who underwent the two interviews within 19 days, and 0.42 for those who waited longer than 19 days. For anxiety disorders the corresponding kappas were 0.72, 0.77, and 0.63.
Eleven participants who were diagnosed with a total of 17 conditions were used in the inter-rater reliability analysis of the diagnoses assessed by expert opinion; there was agreement about 11 conditions (65%). There was disagreement about six conditions (35%) concerning co-morbidity. For two conditions (12%), the initial expert opinion gave a diagnosis and the second rater did not; in another two conditions (12%), the reverse occurred. There was also major diagnostic disagreement about two additional conditions (12%) of co-morbidity. In some cases of disagreement, the second rater’s expert opinion diagnosis was in agreement with the MINI diagnosis and in conflict with the expert opinion. For instance, in one case, both the second rater and the MINI identified drug use, whereas the first expert diagnosed personality disorder (Additional file 2: Table S2).
Inter-rater reliability estimates of diagnoses assessed by the initial clinical intake interview and by the second rater (N = 11)
Cohen’s kappa (95% CI)
In the inter-rater analysis of the diagnoses assessed by MINI, eight participants were diagnosed with 13 conditions; there was agreement about nine conditions (69%). In two conditions (15%) diagnosed by the initial MINI team as alcohol dependence and major depressive disorder, the second rater found no diagnosis. One condition (8%) was assessed as a dissocial personality disorder by the initial MINI team and as a psychotic disorder by the second rater, and one condition (8%) was diagnosed as major depressive disorder by the initial MINI team and as a dissocial personality disorder by the second rater (Additional file 3: Table S3).
Inter-rater reliability estimates for diagnoses assessed by the initial MINI assessment and by the second rater (N = 8)
Cohen’s kappa (95% CI)
The MINI and expert diagnoses in deaf and severely hard-of-hearing signers referred for psychiatric evaluation show fair to substantial agreement. For validation against expert opinion, the kappa estimates in the present study are higher than those of Otsubo et al.  but lower than those of Kadri et al. . Pinninti et al.  and Bobes  also used expert opinion for validation but did not offer kappa values.
The kappa scores were lower than those of studies that have validated MINI against SCID-P [5, 15, 17] and CIDI . This is in line with other validation studies [13, 15, 19]. The kappa values in validations of the MINI against expert opinion were generally lower than when the MINI has been validated against a structured diagnostic instrument such as SCID-P or CIDI [4, 5, 15, 17]. Only Kadri et al.  report relatively high concordance with expert opinion. The open clinical interview and the structured MINI interview represent different approaches to assessing mental disorders, and complete agreement therefore cannot be expected. Structured psychiatric interviews are designed to elicit information about core symptoms of a set of mental disorders, and the concordance of two structured interviews is therefore likely to be higher than for a structured and an open interview. The diagnostic reflections of experts using an open diagnostic interview are likely more diverse than the focused questions and selected list of disorders in the structured interviews.
The concordance of diagnoses was examined by two different methods because the sample size limited the use of kappa statistics. A broad range of diagnoses was found, some with very low frequency. Cohen’s kappa is a conservative indicator and functions best with larger samples. It is unlikely to be reliable when a diagnosis is assessed in fewer than five per cent of a sample . Only “depressive disorders” and “anxiety disorders” were identified frequently enough to assess reliable kappa scores. Matrixes were therefore drawn to show the distribution of diagnoses assessed with the two diagnostic methods and in the inter-rater reliability procedure. This concordance analysis indicates disagreement in approximately one-third of the diagnoses, with most disagreements related to the participants’ second diagnosis (co-morbidity). This finding applies to the validation of MINI versus expert opinion as well as to the inter-rater reliability of the expert diagnosis.
The main question in the present study is whether the NSL version of the MINI functions in the same manner as do other versions of the MINI when compared with expert opinion. Some of the lack of agreement between the two approaches may be caused by differences in diagnostic options. The MINI includes a limited number of diagnoses, and assessors will have to conform to those diagnoses or assign “no diagnosis”. Relying on the MINI for diagnostic assessment may therefore influence the direction of the evaluation, as clinicians attempt to comply with the diagnoses at hand. Clinicians who conduct an open interview have a wider range of diagnoses to consider, which again may shape the direction of their clinical line of thought and the resulting diagnosis. The fact that the kappa values in this study were in the lower range compared with other validation studies may also be partly explained by the presence of less severe disorders and fewer symptoms among the outpatients in this study than among the inpatients and acute ward patients assessed in most other studies (see Table 1).
The MINI indicated a larger number of co-morbid conditions than did the expert opinion. Similar results have been reported in other studies [15, 19] and suggest that the structure of the MINI may make the clinician more attentive to symptoms related to disorders additional to the main diagnosis, and that this attentional shift reduces diagnostic shadowing. This interpretation speaks in favour of including the MINI in routine assessment of signers, as is practiced for hearing patients. On the other hand, assessing severe and complex mental conditions by diagnostic categories exclusively may also increase the probability that symptoms are overlooked.
The MINI was originally developed to meet the need for a structured assessment instrument that could be administered in minimal time. In the present study, the average MINI assessment required almost three times the estimated “less than 20 minutes” . There may be several reasons for this. The interviews were conducted by two therapists, a method requiring collaboration and coordination, which may account for part of the extra time used. Furthermore, as was pointed out by Black and Glickman , many deaf patients with mental disorders do not have full mastery of sign language and may struggle in expressing themselves and in comprehending what is being communicated to them, and this may lead to many repetitions. Finally, the interviewer cannot simultaneously take notes and communicate with the patient, and consequently the time needed for taking notes will add to the total interview time . However, the reason for including the MINI as an assessment instrument for deaf and severely hard-of-hearing persons was to improve consistency, not to reduce assessment time.
The two most frequent diagnostic categories in the present study were “depressive disorders” and “anxiety disorders”. This result is similar to that of studies of psychiatric patient populations in general [8, 31, 32] as well as studies of mental disorders in signing deaf and hard-of-hearing patients [3, 33]. To ensure that the open clinical intake interview would serve as expert opinion for the validation of the NSL version of the MINI, these two categories were used to assess inter-rater reliability. A second rater re-diagnosed the participants from video-recordings of the original assessment interviews, a common procedure in reliability studies . To our knowledge, this approach has not been applied before in research with deaf and severely hard-of-hearing persons. It poses quite a few challenges to the second rater, who is forced to follow “the diagnostic route” of the clinician who conducted the initial assessment. This is no problem if the second rater agrees with the first, but second raters cannot collect additional information or follow alternative diagnostic routes when they disagree with the assumption of the original assessor. We do not know whether this issue influenced the concordance estimates in the present study.
The average time span between the two assessments was longer than reported in other validation studies of the MINI. Twenty-six per cent of the participants went through both interviews the same day, which may seem optimal. However, participation was voluntary and cancellations and postponements of appointments were rather common. Furthermore, the participants’ symptoms may have influenced their daily functioning and ability to keep appointments. The centralised service for this geographically scattered patient population is likely to have bearing on the time between assessments. When participants lived far from the outpatient clinic and the assessments could not be made on the same or consecutive days, the result was sometimes a long interval between assessments. However, kappa values for assessments made with short and long intervals were quite similar.
There are some limitations to this study. First, the relatively small sample size, broad range of diagnoses, and low numbers for some diagnoses limit the reliability of kappa statistics. Another disadvantage of kappa statistics is that scores indicating adequate or inadequate reliability may be considered arbitrary. To be stringent, the rather strict classification scheme suggested by Shrout  was used.
The kappa scores in the present validation of the NSL version of the MINI and the observed agreements with expert opinion do not differ substantially from those of other validation studies. The NSL version appears to be a reliable diagnostic interview for assessing mental disorders in signing persons, provided that it is used by professionals with appropriate sign language skills and knowledge about the patient group. The results of the present study therefore encourage translation of the MINI into other sign languages.
The authors thank all the participants and professionals who participated and contributed to this study. Special thanks to Halvor Nordeng, clinical psychologist, and Professor Svein Friis for valuable contributions. The study was fully funded by Oslo University Hospital.
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