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Table 6 Trends on clinical outcomes, HRQoL and attitude toward treatment

From: Compliance, persistence, costs and quality of life in young patients treated with antipsychotic drugs: results from the COMETA study

 

DAI total score Mean (SD)

PANSS total score Mean (SD)

GAF Mean (SD)

CGI-S Mean (SD)

EQ-VAS Mean (SD)

EQ-utility Mean (SD)

SF-36 PCS Mean (SD)

SF-36 MCS Mean (SD)

 

Non naïve

Naïve

Non naïve

Naïve

Non naïve

Naïve

Non naïve

Naïve

Non naïve

Naïve

Non naïve

Naïve

Non naïve

Naïve

Non naïve

Naïve

Enrolment visit

43.9 (5.0)

41.0 (5.8)

85.5 (27.2)

98.2 (26.1)

54.6 (13.9)

49.9 (13.0)

4.2 (1.1)

4.6 (0.9)

63.7 (18.0)

63.3 (18.4)

0.71 (0.3)

0.68 (0.3)

47.8 (9.2)

48.3 (9.6)

39.5 (9.6)

37.1 (10.9)

Follow-up Examinatio2

43.9

41.7

79.8

81.1

57.1

58.6

4.1

3.9

66.2

67.8

0.74

0.76

48.2

48.7

40.6

39.8

(5.0)

(4.8)

(27.4)

(25.7)

(13.7)

(12.6)

(1.1)

(1.2)

(16.8)

(14.6)

(0.3)

(0.2)

(9.5)

(9.0)

(9.3)

(9.5)

Follow-up examination3

44.2

42.1

75.3

76.1

59.4

62.4

3.9

3.7

68.0

72.2

0.75

0.80

49.1

51.9

41.5

42.0

(4.8)

(5.1)

(27.0)

(24.5)

(14.3)

(12.0)

(1.2)

(1.1)

(16.6)

(14.4)

(0.3)

(0.2)

(9.3)

(8.1)

(8.9)

(8.0)

Follow-up examination4

44.2

42.6

71.4

66.9

61.4

67.6

3.8

3.4

70.5

75.5

0.79

0.81

49.7

53.5

41.9

43.0

(4.8)

(5.2)

(25.8)

(21.1)

(14.2)

(11.5)

(1.2)

(1.1)

(16.6)

(14.7)

(0.2)

(0.2)

(8.9)

(6.6)

(8.9)

(10.0)

Time effect*

F(2.7,1254) = 2.7 P = 0.053

F(2.3,1752) = 156.9 P < 0.0001

F(2.4,1752) = 132.6 P < 0.0001

F(2.5,1752) = 68.9 P < 0.0001

F(2.7,1581) = 25.9 P < 0.0001

F(2.8,1569) = 10.9 P < 0.0001

F(2.8,1434) = 14.1 P < 0.0001

F(2.8,1434) = 17.1 P < 0.0001

Time effect between subgroups*

F(2.7,1254) = 1.1 P = 0.360

F(2.3,1752) = 22.7 P < 0.0001

F(2.4,1752) = 25.9 P < 0.0001

F(2.5,1752) = 14.3 P < 0.0001

F(2.7,1581) = 2.3 P = 0.080

F(2.7,1569) = 1.6 P = 0.192

F(2.8,1434) = 3.5 P = 0.017

F(2.8,1434) = 3.0 P = 0.033

  1. *Time effect refers to the differences estimated between mean observations at any pair of examinations, during the observational period, on the full sample.
  2. § Time effect estimated comparing two subgroups: non naïve versus naïve patients.
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BMC Psychiatry

ISSN: 1471-244X

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