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Table 4 Scales scores evolutions between baseline to acute endpoint (Week 6) and overall endpoint (Week 24)

From: Inhibition/activation in bipolar disorder: validation of the Multidimensional Assessment of Thymic States scale (MAThyS)

  Manic n = 36 Hypomanic n = 31 Mixed n = 26 Depressive n = 47
Scale; mean, total score (SD) / 95%CI Change baseline-acute endpoint Change baseline-endpoint Change baseline-acute endpoint Change baseline-endpoint Change baseline-acute endpoint Change baseline-endpoint Change baseline-acute endpoint Change baseline-endpoint
MAThyS without item 5 −24.8 (29,2) [−35.7; -13.9] −25.6 (25.6) [−34.5; -16.7] −33.0 (31.7) [−44.6; -21.3] −34.4 (34.0) [−46.8; -21.9] −12.9 (27,0) [−24.2; -1.5] −26.3 (42.0) [−43.6; -9.0] 18.0 (26,9) [9.8; 26.1] 18.2 (33.3) [8.4; 28.0]
Factor 1 −21.7 (32.5) [−33.6;-9.8] −24.5 (28.8) [−34.4;-14.6] −35.6 (36.6) [−49.0;-22.2] −34.4 (42.7) [−50.1;-18.7] −6.1 (32.8) [−19.9;7.8] −21.8 (44.7) [−40.2; -3.3] 25.3 (29.1) [16.4;34.1] 26.9 (34.2) [16.8;36.9]
Factor 2 −27.2 (34.6) [−40.1;-14.3] −26.2 (30.0) [−36.6;-15.7] −28.4 (33.8) [−40.8;-16.0] −34.3 (30.1) [−45.3;-23.3] −24.5 (29.9) [−37.2;-11.9] −35.7 (45.8) [−54.6;-16.8] 4.9 (32.0) [−4.7;14.6] 3.3 (38.3) [−8.0;14.6]
HAMA −2.7 (4.9) [−4.5; -0.9] −2.3 (4.8)[ −3.9; -0.6] −5.5 (5.9) [−7.7; -3.3] −5.7 (7.4) [−8.3; -3.0] −7.3 (6.3) [−9.9; -4.7] −7.6 (7.9) [−10.8; -4.4] −6.8 (6.6) [−8.7; -4.8] −6.8 (7.2) [−8.9; -4.7]
HAMD-17 −1.8 (4.6) [−3.5; -0.1] −1.7 (5.0) [−3.5; 0.0] −3.1 (4.6) [−4.9; -1.4] −3.2 (6.4) [−5.6; -0.8] −5.6 (6.6) [−8.3; -2.9] −5.5 (6.7) [−8.2; -2.8] −8.5 (6.2) [−10.4; -6.6] −8.0 (7.2) [−10.1; -5.9]
YMRS −13.7 (9.4) [−17.1; -10.2] −14.0 (10.9) [−17.8; -10.2] −13.1 (6.0) [−15.3; -10.9] −14.5 (7.4) [−17.2; -11.8] −9. 7 (7.9) [−13.0; -6.3] −10.6 (8.0) [−13.9; -7.3] −0.9 (3.5) [−2.0; 0.2] −0.8 (3.2) [−1.8; 0.2]
  1. Abbreviations: HAMA, Hamilton Anxiety Scale; HAMD-17, 17-item Hamilton Depression Scale; MAThys, Multidimensional Assessment of Thymic State; SD, standard deviation; YMRS, Young Mania Rating Scale.