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Table 2 Demographics and clinical characteristics according to baseline plasma oxytocin level

From: Plasma oxytocin changes and anti-obsessive response during serotonin reuptake inhibitor treatment: a placebo controlled study

 

All patients n = 36

Baseline oxytocin level

Low mode range: 16.6-24.5 pg/ml n = 13

Medium mode range: 27.8-40.3 pg/ml n = 17

High mode range: 50.6-67.0 pg/ml n = 6

Sex, males/females, n (% males)

17/19 (47)

5/8 (38)

10/7 (59)

2/4 (33)

Age, years

40.7 ± 12.7

37.6 ± 12.2

43.5 ± 12.6

39.4 ± 14.7

Cohabiters/singles, n (% cohab.)

20/16 (44)

9/4 (31)

10/7 (41)

1/5 (83)

Any divorce, yes/no, n (% yes)

10/26 (28)

5/8 (38)

5/12 (29)

0/6 (0)

Having children, yes/no, n (% yes)

18/18 (50)

5/8 (38)

10/7 (59)

3/3 (50)

Number of children

1.0 ± 1.2

0.7 ± 0.9

1.2 ± 1.4

1.0 ± 1.1

Full time work, yes/no, n (% yes)

13/22 (37)

4/9 (31)

7/9 (44)

2/4 (33)

OCD, age of onset, years

14.5 ± 6.5

16.2 ± 4.7

13.7 ± 7.6

13.0 ± 6.8

OCD duration, years

26.2 ± 14.8

21.4 ± 14.9

29.8 ± 13.6

26.4 ± 17.1

Familial OCD, yes/no, n (% yes)

14/10 (58)

6/3 (67)

5/6 (45)

3/1 (75)

History of tics, yes/no, n (% yes)

8/26 (24)

2/11 (15)

3/12 (20)

3/3 (50)

Autistic traits, yes/no, n (% yes)

11/23 (32)

5/8 (38)

5/10 (33)

1/5 (17)

History of poor insight, yes/no, n (% yes)

6/27 (18)

1/11 (8)

4/11 (27)

1/5 (17)

Y-BOCS score, baseline

25.3 ± 5.9

23.5 ± 6.2

25.5 ± 5.8

28.8 ± 4.7

NIMH-GOCS score, baseline

9.4 ± 2.0

8.8 ± 2.2

9.6 ± 1.7

10.2 ± 2.1

MADRS score, baseline

12.2 ± 7.8

12.2 ± 8.4

12.2 ± 8.4

12.2 ± 5.9

Previous SRI treatment, yes/no, n (% yes)

12/24 (33)

3/10 (23)

6/11 (35)

3/3 (50)

  1. Mean values ± standard deviations unless otherwise stated. In Chi-2 and one-way ANOVA tests, all the comparisons of these three groups were non-significant. However, for cohabitation the overall result was χ 2 = 4.7 (2), p = 0.09, and comparison between the highest mode and the merged lower modes resulted in χ 2 = 4.4 (1), p = 0.036.
  2. MADRS = Montgomery Åsberg Depression Rating Scale; NIMH-GOCS = National Institute of Mental Health Global Obsessive Compulsive Scale; OCD = obsessive-compulsive disorder; SRI = serotonin reuptake inhibitors; Y-BOCS = Yale-Brown Obsessive Compulsive Scale.