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Table 4 Gene expression (mean ± SE) for genes differing between BPD and MDD subgroups

From: Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls

GENE

BPD (n=10)

MDD (n=13)

p valueA

η2

APP

7.63E-01± 4.80E-02

5.98E-01 ± 4.33E-02

0.006

0.303

CREB1

7.40E-01 ± 4.75E-02

6.39E-01 ± 2.15E-02

0.028

0.210

NFKB1

5.81E-01 ± 2.42E-02

5.29E-01 ± 1.99E-02

0.038

0.179

NR3C1

3.27E-01 ± 2.81E-02

2.78E-01 ± 9.51E-03

0.043

0.191

SPARC

3.20E+00 ± 2.72E-01

2.29E+00 ± 1.80E-01

0.003

0.300

TNF

1.36E-01 ± 5.99E-03

1.68E-01 ± 1.14E-02

0.032

0.200

  1. Raw data is displayed in the table. Expressed in scientific notation units where E+00 = x1, E-01 = x0.1, E-02 = x0.01, etc. Data were log transformed prior to analysis.
  2. ABPD vs. MDD using 5 factor regression model with inclusion of age, QIDS-SR, anticonvulsant use, and antidepressant/antipsychotic use. Model has 23 patients, 5 variables, results in 17 degrees of freedom.
  3. p value is for effect of Diagnostic subgroup after adjusting for the effects of the other 4 factors.
  4. Effect sizes using η2 for where diagnostic subgroup was significant in the regression model were consistently large (>0.14).