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Table 3 Criteria for the evaluation of psychiatric symptom aggravation/recurrence

From: Japan useful medication program for schizophrenia (JUMPs)-long-term study on discontinuation rate, resolution and remission, and improvement in social functioning rate associated with atypical antipsychotic medications in patients with schizophrenia

Satisfaction of at least 1 of the following 4 requirements

1)

CGI-I is 5 (minimally worse) or higher, and at least 1 of A and B is satisfied

 

  A. Scored 5 (moderate severe) or higher in any of the following PANSS items, i.e., “disturbed concept integration (P2)”, “hallucination-based behavior (P3)”, “doubt/persecutory sense (P6)”, and “unnatural thought content (G9)” with a score on such item(s) being higher by 2 or more points from the baseline score

  B. Scored 5 (moderate severe) or higher in any of the following PANSS items, i.e., “disturbed concept integration (P2)”, “hallucination-based behavior (P3)”, “doubt/persecutory sense (P6)”, and “unnatural thought content (G9)”, with a total score on these 4 items being higher by 4 or more points from the baseline score

2)

Hospitalized based on psychiatric symptom aggravation

3)

CGI-SS Part 1 rating of 4 (severely suicidal) or 5 (attempted suicide), or CGI-SS Part 2 rating of 6 (much worse) or 7 (very much worse)

4)

Behaved violently, causing clinically serious self-injury, injury to other people, or destruction of objects