Skip to main content

Advertisement

Table 1 Summary of long-acting methylphenidate (MPH) formulations

From: Long-acting methylphenidate formulations in the treatment of attention-deficit/hyperactivity disorder: a systematic review of head-to-head studies

MPH formulation Synonyms Product availability Modified-release technology Immediate-release: extended-release ratio (%) Duration of actiona
Biphentin® [10] MPH ER Canada Multilayer-release (MLR) bead formulation 40:60 Not stated: biphasic delivery profile
Concerta® [12] Concerta extended release; Concerta® LP; methylphenidate hydrochloride; OROS MPH Africab, Asiac, Australia, Europed, New Zealand, North Americae, South Americaf OROS® (Osmotic Release Oral System) 22:78 12 hours
Daytrana® [13] MPH transdermal system; MethyPatch; MTS USA Transdermal patch Continuous delivery 9 hours
Equasym XL® [11] Equasym Depot®; Equasym Retard®, Equasym XR®, Quasym LP®; Metadate CD®; Metadate ER® Europeg, South Korea, USA Diffucaps® 30:70 8 hours
Focalin XR® [7] d-MPH-ER Switzerland, USAh SODAS® (Spheroidal Oral Drug Absorption System) 50:50 Not stated: two distinct peaks approximately 4 hours apart
Medikinet® retard [9] Medikinet®; Medikinet® CR; Medikinet® EM; Medikinet® MR; Medikinet® XL Europei, Israel, Korea, South Americaj Modified-release capsules 50:50 8 hours
Ritalin LA® [6] Ritalin LP®; Miacalcic France, Chile, USAh SODAS® (Spheroidal Oral Drug Absorption System) 50:50 Not stated: two distinct peaks approximately 4 hours apart
Ritalin SR® [5] n/a Canada, USAh Wax matrix Continuous release 8 hours
  1. aDuration of action as stated in the prescribing information.
  2. bBotswana, Brazil, Egypt, Namibia, Nicaragua, South Africa.
  3. cBahrain, China, Hong Kong, Indonesia, Israel, Japan, Jordan, Republic of Korea, Kuwait, Lebanon, Malaysia, Oman, Philippines, Qatar, Saudi Arabia, Singapore, Taiwan Province of China, United Arab Emirates, Yemen.
  4. dAustria, Belgium, Croatia, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Iceland, Ireland, Latvia, Lichtenstein, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, UK.
  5. eBahamas, Barbados, Canada, Cayman Islands, Dominican Republic, El Salvador, Guatemala, Honduras, Jamaica, Mexico, Trinidad and Tobago, USA.
  6. fArgentina, Aruba, Bolivia, Chile, Columbia, Costa Rica, Ecuador, Panama, Paraguay, Peru, Uruguay, Venezuela.
  7. gDenmark, Finland, France, Germany, Ireland, the Netherlands, Norway, Sweden, Switzerland, UK.
  8. hInformation obtained from Thomson Cortellis™.
  9. iAustria, Belgium, Cyprus, Denmark, Estonia, Finland, France, Germany, Ireland, Italy, Latvia, Lithuania, Luxembourg, the Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, UK.
  10. jArgentina, El Salvador, Guatemala, Honduras.