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Interventions to improve executive functioning and working memory in school-aged children with AD(H)D: a randomised controlled trial and stepped-care approach
BMC Psychiatry volume 13, Article number: 23 (2013)
Deficits in executive functioning are of great significance in attention-deficit/hyperactivity disorder (ADHD). One of these executive functions, working memory, plays an important role in academic performance and is often seen as the core deficit of this disorder. There are indications that working memory problems and academic performance can be improved by school-oriented interventions but this has not yet been studied systematically. In this study we will determine the short- and long-term effects of a working memory - and an executive function training applied in a school situation for children with AD(H)D, taking individual characteristics, the level of impairment and costs (stepped-care approach) into account.
The study consists of two parts: the first part is a randomised controlled trial with school-aged children (8–12 yrs) with AD(H)D. Two groups (each n = 50) will be randomly assigned to a well studied computerized working memory training ‘Cogmed’, or to the ‘Paying attention in class’ intervention which is an experimental school-based executive function training. Children will be selected from regular -and special education primary schools in the region of Amsterdam, the Netherlands. The second part of the study will determine which specific characteristics are related to non-response of the ‘Paying attention in class’ intervention. School-aged children (8–12 yrs) with AD(H)D will follow the experimental school-based executive function training ‘Paying attention in class’ (n = 175). Academic performance and neurocognitive functioning (primary outcomes) are assessed before, directly after and 6 months after training. Secondary outcome measures are: behaviour in class, behaviour problems and quality of life.
So far, there is limited but promising evidence that working memory – and other executive function interventions can improve academic performance. Little is know about the applicability and generalization effects of these interventions in a classroom situation. This study will contribute to this lack of information, especially information related to real classroom and academic situations. By taking into account the costs of both interventions, level of impairment and individual characteristics of the child (stepped-care approach) we will be able to address treatment more adequately for each individual in the future. Trial registration: Nederlands Trial Register NTR3415.
Studies show that children with Attention Deficit Hyperactivity Disorder (ADHD) often suffer from deficits in executive functions, such as attentional control, inhibition and working memory [1, 2]. Stimulant medication may reduce the behaviour symptoms of ADHD but they can also have serious side effects and the effects on cognitive- and executive functioning remain unclear . It is known that these executive functions play an important role in academic performances . Especially working memory skills are associated with problems in learning and poor classroom behaviour [5, 6]. Working memory refers to the function of actively holding in mind and manipulating information relevant to a goal . Individuals with poor working memory functioning are at risk of poor educational progress, over 85% of children with poor working memory have problems in reading or mathematics . Recently, studies have shown that training of the working memory has positive xeffects for children with ADHD, and/or learning disabilities [9, 10]. Children who followed the computer-based working memory training program (Cogmed Working Memory Training, 10) not only showed improved working memory abilities over time, but also showed better performance on related executive function tasks such as logic reasoning and response inhibition and still continued to show effects after 3 months [9, 10]. Interestingly, Holmes and colleagues  examined the effects of this working memory computer-based training on measures of academic ability. Adaptive working memory training proved to be associated with higher achievement on mathematic and working memory tasks immediately and after a period of 6 months. In this study a classroom analogue of a working memory task (e.g. following instructions) was carried out, which showed improvement as well. So far, research aimed to study the effects of working memory training on academic performance is promising [11, 12]. However, few studies have paid attention to the transfer effects of working memory training on behaviour in a classroom setting. Recently, Green and colleagues  showed that working memory training in children with ADHD leads to significant reductions of ‘off-task’ behaviour during academic task performance. But they also noted that the absence of measurable effects of working memory training on teacher ratings in previous studies is a notable limitation of the training. Also, methodological issues such as information bias using only teacher reports and having a small sample size  were limitations in earlier studies. The aim of our first study is to replicate the above results of working memory training in a Dutch population of school-aged children with AD(H)D. Moreover it will add specific information on academic performance and behaviour in a classroom setting. From a clinically point of view it is expected that improved working memory also has positive effects on functioning in daily life, therefore we will also focus on quality of life. Besides replicating and extending the results from earlier Cogmed studies, we also compare Cogmed with an experimental school-based executive function training. We developed this training from a clinical point of view. Cogmed is a licensed intervention which creates significant costs for healthcare institutions, healthcare insurance companies and parents. Also, from clinical practice we know that (special aid) teachers lack knowledge about executive functioning and its relation to academic performance and behaviour in class. For instance, they need more specific information and practical tools to guide these impaired children throughout their school career, as described by Gathercole and Alloway . Cogmed is a core working memory training, not contextual to a school environment, and teachers are not involved in the treatment when following the Cogmed protocol. Our ‘Paying attention in class’ intervention is an executive function training, contextual to the school environment. This will be extensively explained below in the Method section.
The aim of the first study is to examine the effects of a working memory – and executive function training on academic performance, neurocognitive functioning, behaviour in class, behaviour problems and quality of life of children with AD(H)D between the age of 8 and 12 years.
The aim of the second study is to investigate which specific characteristics are related to non-response of the ‘Paying attention in class’ intervention. By offering Cogmed to the non-responders, we will obtain insight into the effectiveness of both interventions, taking into account individual characteristics, the level of impairment and the costs (stepped-care approach).
With the result of both studies we hope to obtain more insight in the effective elements of both interventions so that treatment can be more individually tailored in the future.
The ethics approval was obtained from the Medical Ethical Committee (2011_269) at the Academic Medical Centre in Amsterdam, the Netherlands.
The first study is a randomised controlled trial in which children will be randomly assigned to the Cogmed RM  intervention (n=50) or the experimental ‘Paying attention in class’ intervention (n=50). We expect that for some children treatment can not be started immediately after enrollment. They will be placed on a waiting list. An extra measurement of academic performance and neurocognitive functioning (primary outcomes) will be administered for the children on the waiting list, this will be a control group (n=50). The second study partially replicates and also extends the first study. This second study investigates which specific characteristics are related to a non-response of the ‘Paying attention in class’ intervention, which requires 175 children including the 50 children from the first study. Based on ethical considerations, Cogmed RM  will be offered to the non-responders of the ‘Paying attention in class’ intervention after the follow up assessment (6 months).
We will approach three types of primary schools in the region of Amsterdam, the Netherlands: regular primary, special primary education and special education schools. The research team closely collaborates with expert divisions on Special Education and ADHD of the Bascule, Academic Centre for Child and Adolescent Psychiatry, Amsterdam.
For this study children will be recruited in two ways. First, children from clinical care can be enrolled by contacting a member of the research team. Second, children can be enrolled by their school. In both cases, recruitment will take place by approaching a principal and/or remedial teacher via email or telephone. A special information meeting will be held to extensively inform the staff and ask for permission to participate in the study. Once a school agrees to participate, we will work with a staff member (usually remedial teacher or school psychologist) to select children that meet the criteria for participation. Then parents of these selected children will be approached and informed by the school staff member, followed by an extra information meeting especially for parents. Parents receive an application package including an informed consent form. Training will be started after the informed consent is signed by both parents.
Inclusion and exclusion criteria
Children participating in this study are between the age of 8 and 12 years and diagnosed with AD(H)D by a professional according to the guidelines of the Diagnostic and Statistic Manual of Mental Disorders DSM-IV . Children with co morbid Learning Disabilities (LD) and/or Oppositional Defiant Disorder (ODD) are included as well. Both children with or without medication (e.g. stimulants) are included. Children with medication are only included when they are well adjusted to their medication, which means they are not participating in a medication trial and type and dosage of medication is unchanged at least 4 weeks prior to the start and during the training.
Exclusion criteria are (a) psychiatric diagnoses other than AD(H)D/LD/ODD; (b) Total Intelligence quotient <80; (c) significant problems in the use of the Dutch language; (d) severe sensory disabilities (hearing/ vision problems).
For the first study, the Clinical Research Unit of the Academic Medical Centre composed a randomisation list, stratified by age. Children will be individually randomised to either the Cogmed RM  or ‘Paying attention in class’ intervention group by a researcher independent of the research team. This researcher will subsequently inform the therapist about the allocated condition for each child. The PhD student and research assistant will be blind for the allocation.
Developmental psychologists will be trained as ‘training aides’ according to the Cogmed working memory training protocol. They will also be trained as therapists for the ‘Paying attention in class’ intervention. This training consists of an interactive 3 hour course, provided by a member of the research team. For both interventions the developmental psychologists will receive weekly supervision by a certified Cogmed Coach and clinical staff member of the Bascule in which they can discuss the progress and clinical difficulties.
All supervision sessions will be registered with the aid of a structured format. Also, the trainers will fill out a logbook per child daily, for observations and special circumstances. Finally the Cogmed Training Web and the ‘Paying attention in class’ workbook will be used to monitor the results of the training. These three documents will be used to create a checklist for evaluating treatment fidelity.
Cogmed working memory training RM
Cogmed Working Memory Training RM is specifically used for children between the age of 7 and 17 years. It consists of a variety of computerized, game-format, working memory tasks that are adaptive, which means that difficulty level is being adjusted automatically to match the working memory span of the child on each task. The program includes 12 visuospatial and verbal working memory tasks, eight of these tasks (90 trials in total) are being completed every day . The child follows the standard Cogmed RM protocol which means following the computer training program for 5 weeks, 5 times a week, approximately 45 minutes a day. The program is provided via the internet on a laptop and the child is trained individually at school, guided by a trained developmental psychologist. Cogmed is a licensed intervention that entails significant costs for healthcare professionals / institutions, health care insurance companies and (depending on type of health care insurance) also parents. The Cogmed Coach Training costs €950, exclusive of a monthly license fee which is dependent on the amount of licenses used. A user ID for one child costs €99. In some cases the monthly fee and user ID costs are reimbursed by the healthcare insurance but there always is a statutory contribution of €100 (in the Netherlands), which is often paid by parents.
Paying attention in class
‘Paying attention in class’ is an experimental executive function training that has been developed by our research team. The child is trained individually for 5 weeks, 5 times a week, approximately 45 minutes a day; the same duration as in the Cogmed protocol. This ‘Paying attention in class’ has three aims. First of all, the most important aim of this intervention is to offer psycho education about executive functions that are related to classroom behaviour. By making children more aware of these executive functions needed for adequate classroom behaviours, they obtain more insight in their own learning behaviour. The psycho education addresses five executive functions that are important in a learning situation, namely: paying attention, planning skills, working memory, goal-directed behaviour and metacognition. It will be offered through a MP3 player, based on a ‘brain castle’ theme in which specific compensatory strategies and pitfalls are explained to the child. Every session starts with psycho education that is related to one of the above mentioned executive functions. After hearing this, the child is asked to make a neuropsychological - and school task related exercise in which the psycho education has to be applied. The second aim of this intervention is to train working memory functions. This is done by three adaptive working memory tasks: one visual-, one verbal-, and one instruction paradigm task (30 trials in total). The child will be encouraged to use the compensatory memory-strategies from the psycho education. The third and final aim of this intervention is to make a transfer to a classroom-situation, this will be achieved through several ways. First of all, the strategies introduced through the psycho education as described above will be illustrated and practiced by performing school related tasks. Second, the child brings a registration card to class that reminds him/her of the practiced skill of the day (for example, ‘I repeat what is said’). This card includes the name of the specific compensatory strategy. By using a registration card, the child will be reminded what to practice in the classroom. Also it will inform the teacher about the specific executive function and strategy that is practiced on that day so that he/she can reward the child for applying it in class. Finally, to optimize the transfer from the training session to a situation in class we closely involve the teacher in the process by informing him/her with the protocol and by giving him/her an active part in the process. The teacher will receive psycho education about the use of executive functions in the classroom through a written manual, which will increase their knowledge how to recognize and stimulate such behaviour in learning situations. The teacher also receives structured observation forms daily in which he/she can record whether the child applies the practiced strategies in class. The ‘Paying attention in class’ intervention is experimental, so the exact costs are unknown, but we are aiming at a price of €25 a workbook. The costs of a ‘Paying attention in class’ training will be equal to that of the Cogmed Coach Training but there will not be a monthly license fee.
Measures and procedures
After written informed consent is obtained, parents will fill out an application package which contains questionnaires of demographic and background information such as previous care and medication use. The measurements of academic performance and neurocognitive functioning (primary outcomes) are administered in a child face-to-face meeting which takes place at three consecutive moments: at baseline, directly after treatment and 6 months after treatment. The test battery that will measure academic performance consists of an automated math , a spelling skill test  and technical literacy  test. The neurocognitive functioning test battery consists of tests that measure attention , verbal [19, 20] and spatial working memory , inhibition , planning and goal-directed behaviour . Also, both parents and teachers fill out the ‘The Behaviour Rating of Executive Functions’  questionnaire. The secondary outcome measures of this study are behaviour in class, behaviour problems and quality of life of the children. This will also be measured at the three consecutive moments mentioned above. Behaviour in class will be reported by the teacher using the ‘Leervoorwaardentest’, a questionnaire . Both teacher and parents will rate behaviour problems using ‘The Child Behavior Checklist for Ages 6–18  and ‘Teacher’s Report Form for Ages 6-18’ . Before training is started, the Diagnostic Interview Schedule for Children  and Social Communication Questionnaire  is administered to parents to rule out other behavioural problems or psychiatric problems that meet exclusion criteria. Finally, quality of life is measured by using the Kidscreen-27  questionnaire and is completed by parents and the child. All tests and questionnaires have been selected based on results from a small pilot study and clinical experience. Most of the tests and questionnaires are in line with other relevant international literature. Other aspects that were taken into account were duration of administration, variety of neurocognitive tests that can establish possible near and far transfer effects and methodological points such as presence of Dutch norms and test-retest reliability. Table 1 gives an overview of all the assessments and outcome measures.
For the randomised controlled trial in the first study with two trial arms, 50 children in each trial arm, an effect size of 0.60 can statistically be demonstrated (P < 0.05, 80% power) for comparison of the primary outcome measures of both interventions. This corresponds with an expected clinically relevant difference of 3 points and a standard deviation of 5 on the subtest Digit span from the WISC-III.
For the second study we developed a risk score for the non-responders of the ‘Paying attention in class’ intervention. We expect that 35% (n = 61) of the 175 included children will show no or insufficient result after the 6 month follow up assessment. With 61 “events”, 4 robust true predictors (15 observations per predictor variable) of non-responders can be identified and used for the risk score of non-responders .
Multivariate analysis with repeated measures will be conducted, using SPSS Statistics 19 to evaluate training effects on the primary and secondary outcomes.
About 3-5% of the children in the Netherlands is diagnosed with AD(H)D . From earlier research we know that AD(H)D has a strong correlation with working memory problems [32, 33] which makes it hard for those children to sufficiently benefit from classroom instructions. Treatment with stimulant medications reduces the behaviour symptoms in children with ADHD but the effects on cognitive functioning are less clear. Given the fact that working memory problems and ADHD are both risk factors for academic failure, it is important to develop and investigate interventions that can be implemented at school. Cogmed is already being applied occasionally by school counseling services but the possible transfer effects on academic performance remain unclear. From practice we know that, after thorough diagnostic assessment, both parents and teachers have an urgent need for specific advice on how to cope with and help the child with specific attention and working memory deficits at school or in daily life. Up till now, clinicians provided such advices based on their theoretical and clinical experience, without a standardized method or practical guide to use. With the first study we hope to gain insight in the short and long-term effects of the working memory – and executive function intervention on neuropsychological functioning, academic performance, behaviour in class, behaviour problems and functioning in every day life. This way we can offer health care professionals, teachers and other educational staff members a more standardized and evidenced based guideline in how to approach and treat children with AD(H)D. As mentioned above, Cogmed is a licensed intervention that entails significant costs for healthcare institutions, health care insurance companies and parents. Our intention is to make our experimental ‘Paying attention in class’ available at a low price, which makes it easily accessible for all schools and school counseling services. Healthcare insurance companies require that treatment programs are proven effective, to which we hope to contribute with this study. The second study should give us insight into the effectiveness of both interventions, taking into account individual characteristics, the level of impairment and the costs (stepped-care approach). If both interventions appear to be effective to improve academic performance, they can be implemented in regular and special education schools as an intervention for students who need extra care.
Strengths and limitations
Our study has several strengths and limitations. Our first study is randomised and controlled, which is the strongest design to establish efficacy, and the sample size is large. Second, Green and colleagues  recommended that academic performance, planning, goal attainment and following rules should be assessed as outcome measures in future studies. Our study includes these recommendations by using tests that have been standardized in Dutch samples. Also we assess the quality of life of the children which hasn’t been done in earlier studies. Finally, in both conditions children receive active treatment and children that do not respond sufficiently to the experimental intervention are offered the Cogmed intervention which had already been proven effective. One limitation of this study is that the interventions from the randomised controlled trial differ on certain aspects, primarily on their content and applicability, which could make it difficult to compare the interventions in terms of efficacy. Another limitation, that has been outlined in recent reviews [34, 35], is the use of single tasks to assess the generalization effects of working memory training. It is not clear whether the improved performance reflects change to an underlying ability or reflects practice of a task that strongly resembles trained tasks. Therefore we should be cautious when interpreting results on both near and far transfer effects such as attention or academic performance.
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The pre-publication history for this paper can be accessed here:http://0-www.biomedcentral.com.brum.beds.ac.uk/1471-244X/13/23/prepub
This project is funded by the Ministry of Education, Culture and Science according to the program ‘Onderwijs Bewijs’, project number ODP10030. We would like to thank J.W. Geelhoed2, J.P.M. Vieijra2 and R. Lindeboom4 for the contribution they made to the research proposal for grant application.
All authors declare that they have no competing interests.
MD, AB, AT, AL and RL wrote the current manuscript. MD is the PhD candidate running the study primary in a period of 4 years and will be responsible for collection and analyzing the data. All other authors are supervisors, co investigators and edited the current manuscript. All authors have read and approved the final manuscript.
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van der Donk, M.L., Hiemstra-Beernink, A., Tjeenk-Kalff, A.C. et al. Interventions to improve executive functioning and working memory in school-aged children with AD(H)D: a randomised controlled trial and stepped-care approach. BMC Psychiatry 13, 23 (2013) doi:10.1186/1471-244X-13-23
- School-aged children
- Working memory training
- Executive function training
- Academic performance
- Randomised controlled trial