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Table 2 Details of the initial drug type and dose for all 171 episodes and the adverse effects and median time to sedation for each drug type/combination

From: A prospective study of high dose sedation for rapid tranquilisation of acute behavioural disturbance in an acute mental health unit

Drug type

Initial drug

Dose range (mg)

Adverse effects

Median time to sedation (min)

N = 16

Droperidol

74

5 to 30

Hypotension (3)

20

Midazolam

19

5 to 15

Hypotension (1)

20

Haloperidol

3

10

0

30

Midazolam + droperidol

61

5 to 15 +

Hypotension (8)

25

  

5 to 25

Desaturation/hypotension (1)

Midazolam + haloperidol

12

5 to 10 + 10

Hypotension (2)

10

Desaturation (1)

Droperidol/lorazepam

1

2.5 + 2

0

15

Lorazepam

1

2

 

40